Clinical trials
Severe Obesity clinical trials
Below are recruiting severe obesity clinical trials, each written for real people, not researchers. We’re tracking 30 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06477120Recruiting
Time-restricted eating for pregnant women with severe obesity
This study tests whether eating only during a set window of time each day (time-restricted eating) can help manage weight gain during pregnancy for women with severe obesity. It might offer a safe, simple way to support a healthy pregnancy.
Chicago, IllinoisAges 18–44 - NCT07093502Recruiting
Predicting outcomes after weight-loss surgery for severe obesity
This study is creating a system to predict how well people do after weight-loss surgery for severe obesity. It focuses on patients getting either a sleeve gastrectomy or a gastric bypass and aims to improve recovery and long-term results.
Changsha, HunanAges 18–50 - NCT07368842Recruiting
Scalp hair study in severe obesity
This study looks at chemicals in scalp hair from people with severe obesity to learn more about the condition. Participants must be planning to have weight-loss surgery.
SingaporeAges 21–70 - NCT03472157Recruiting
Bariatric surgery for severe NASH with advanced liver scarring
This study tests whether bariatric surgery (either sleeve gastrectomy or Roux-en-Y gastric bypass) improves severe nonalcoholic steatohepatitis (NASH) with advanced liver scarring in people who are obese. You may also need liver biopsies to confirm your liver disease before and after treatment.
LilleAges 18–65 - NCT05918575Recruiting
Breathing support after a breathing tube in very obese adults
This trial tests whether giving noninvasive breathing support (using a mask or similar device, without a new breathing tube) right after removing a breathing tube works better for severely obese adults. It mainly looks at people at higher risk of needing help breathing again after extubation.
Chicago, IllinoisAges 18 years+ - NCT04578652RecruitingPhase 3
Test fiber plus metformin for teen weight and insulin resistance
This trial studies whether adding fiber to metformin helps teens with severe obesity and insulin resistance improve how their bodies handle sugar. You might consider it if you’re a teen who isn’t yet diagnosed with type 2 diabetes and meets the specific lab and health criteria.
Edmonton, AlbertaAges 12–18 - NCT07158008Recruiting
Weight loss surgery for people with obesity and heartburn
This study compares two weight-loss surgeries for people who have both obesity and severe heartburn or GERD. One surgery combines part of the stomach removal with an anti-reflux wrap, while the other reroutes the stomach to help with weight loss and reflux.
KrakowAges 18–65 - NCT01129297Recruiting
Severe obesity tissue study during surgery
This study collects small tissue samples during certain abdominal surgeries to better understand what drives severe obesity and related blood-sugar patterns. If you agree to the extra sampling, your information and samples may help researchers build a “biological atlas” that could guide future treatments.
Lille, NordAges 18–65 - NCT06321458Recruiting
Intensive weight loss program vs. usual care for obesity
This trial compares an intensive weight loss program to usual care for adults with severe obesity and related health problems. It aims to see if a structured program helps people lose more weight and improve their health.
FrederiksbergAges 18–60 - NCT02310178Recruiting
Long-term follow-up after bariatric surgery at Montpellier
This study follows people who have had weight-loss surgery at Montpellier University Hospital to see how they do over time. It helps doctors understand the long-term benefits and challenges after surgery.
MontpellierAges 15 years+ - NCT03821636Recruiting
Compare gastric bypass limb lengths for type 2 diabetes remission
This study looks at whether a gastric bypass surgery with a longer intestine segment or a longer bile drainage segment leads to better type 2 diabetes remission in people with severe obesity. It may help doctors choose the most effective surgical approach and follow-up plan for diabetes improvement.
AmiensAges 18–60 - NCT01998750Recruiting
Study of genes in severe early childhood obesity
This study looks for genetic (inherited) reasons for severe obesity that starts in very early childhood. It may help doctors better understand the cause of your child’s weight gain and guide future treatment.
Boston, MassachusettsAges Up to 80 years - NCT05120492Recruiting
Program for severe knee arthritis and extreme weight
This feasibility study tests a practical approach to help people with very severe knee arthritis and very high body weight. It aims to find an effective and safe way to manage both conditions together in real-world care.
Halifax, Nova ScotiaAges 18–65 - NCT07058155RecruitingPhase 4
TIPS and weight-loss surgery for liver disease with high blood pressure
This trial tests if doing a TIPS procedure (to lower blood pressure in the liver) before weight-loss surgery (sleeve gastrectomy) helps people with advanced liver disease. It's for those who have cirrhosis and very high blood pressure in the liver, and who qualify for sleeve gastrectomy.
Cleveland, OhioAges 18–70 - NCT06426290Recruiting
Predicting success after weight-loss surgery
This study looks at whether a psychological test can help predict who will do well after weight-loss surgery. Researchers are reviewing past test results and surgery outcomes to find patterns.
MoulinsAges 18 years+ - NCT06547515Recruiting
Bone and muscle health after sleeve gastrectomy
This study looks at how sleeve gastrectomy surgery affects bone and muscle health in men and women at different life stages (before and after menopause). It compares people having the surgery with those who qualify but don't have it.
QuébecAges 18 years+ - NCT06757296Recruiting
Endoscopic revision of sleeve gastrectomy for reflux or poor weight loss
This study tests a new, less invasive way to convert a sleeve gastrectomy into a different type of weight-loss surgery (SASI) in people who have ongoing gastroesophageal reflux or haven't lost enough weight. The goal is to see if this endoscopic procedure can improve reflux and help with weight loss without the need for a traditional surgery.
SingaporeAges 21–65 - NCT06043245Enrolling by invitation
Diabetes remission and weight loss surgery
This trial tests whether a specific type of weight loss surgery can help people with type 2 diabetes stop needing diabetes medication. It is for people with a very high body mass index (BMI over 45) who are currently on diabetes pills or insulin.
L'Hospitalet de Llobregat, BarcelonaAges 18–60 - NCT06309238Recruiting
Intensive diet vs. surgery for severe obesity
This study compares two programs for people with severe obesity: an intensive weight-loss diet and a weight-loss surgery (bariatric surgery). It aims to see which approach works better for long-term health.
AarhusAges 18–60 - NCT06968442Recruiting
Obesity and severe COVID-19 study
This study looks at how obesity affects the body's response to severe COVID-19. It compares people with obesity to healthy-weight healthcare workers to understand differences in the immune system.
Rotterdam, South HollandAges 18–65 - NCT07674290RecruitingPhase 4
Study of MC4R Agonist for Bardet-Biedl Syndrome and Genetic Obesity
This trial tests a drug called setmelanotide for people with Bardet-Biedl Syndrome (a rare genetic condition) or other severe genetic obesity. It looks at how well the drug works in real-world settings, not just in a lab.
EssenAges Any age - NCT06994650RecruitingPhase 3
Study of HRS9531 for sleep apnea and obesity
This trial tests an injection called HRS9531 to see if it helps people with obstructive sleep apnea (OSA) and obesity who already use a CPAP or similar breathing device. It may help by reducing weight and improving breathing during sleep.
Beijing, Beijing MunicipalityAges 18–75 - NCT07085923Recruiting
Heart health study for people with mental illness
This study tests a program to improve heart health in people with schizophrenia or bipolar disorder who take antipsychotic medication or lithium and have a high body weight. The goal is to help reduce heart disease risk.
OsloAges 25–70 - NCT06857942RecruitingPhase 4
Tirzepatide added to ixekizumab for psoriasis and weight issues
This trial tests whether adding tirzepatide (a weight-loss and diabetes drug) to ixekizumab (a psoriasis treatment) helps people with moderate-to-severe psoriasis who are overweight or have obesity. It is for those already taking ixekizumab for about 3 months.
Phoenix, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for severe obesity?
- Yes. Clin2 currently lists 30 recruiting severe obesity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe obesity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe obesity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.