Clinical trials
Severe Brain Injury clinical trials
Below are recruiting severe brain injury clinical trials, each written for real people, not researchers. We’re tracking 270 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07782216Recruiting
Studying brain proteins after acute brain injury
This study looks at how certain brain proteins (called biomarkers) behave in the blood after an acute brain injury. The goal is to see if these proteins can help doctors quickly assess the severity of the injury. Participation involves giving blood samples at specific times after your injury.
Pécs, BranyaAges 18 years+ - NCT06577402Recruiting
Study on energy and protein in severe brain injury patients
This study measures how your body uses energy and protein if you are in the ICU with a severe brain injury while on a breathing machine. It can help doctors better understand your recovery needs.
Nanjing, JiangsuAges 18–85 - NCT07688746RecruitingPhase 1
Helping premature babies heal brain injury
This trial tests a treatment for brain injury in premature babies born before 32 weeks. It aims to protect and repair white matter, the part of the brain that helps nerve cells communicate.
San Francisco, CaliforniaAges 3 weeks–5 months - NCT07719595Recruiting
Vagus nerve stimulation for coma after brain injury
This trial tests if a gentle electrical stimulation of the vagus nerve (a nerve in the neck) can help people regain consciousness after a severe traumatic brain injury. It is for patients who are in a coma or minimally conscious state, and the treatment is given along with standard ICU care.
Stony Brook, New YorkAges 18 years+ - NCT07718321Recruiting
StimolIrpinia for brain injury rehab: a feasibility trial
This trial tests a new cognitive rehab tool called StimolIrpinia for people recovering from a serious brain injury. It aims to see if the tool is acceptable and helpful for improving thinking and memory.
Sant'Angelo dei Lombardi, AVAges 18–75 - NCT03559114RecruitingPhase 3
Preventing blood clots after severe brain injury
This trial tests whether taking an anti–blood clot medicine (dalteparin) and using leg compression can reduce dangerous blood clots after a severe traumatic brain injury. It may help lower the chance of clots forming when people are immobile and at higher risk.
Calgary, AlbertaAges 18 years+ - NCT04117672RecruitingPhase 2
Test antisecretory treatment in severe brain injury
This Phase 2 study tests an “antisecretory factor” treatment in people with severe traumatic brain injury. It may help by improving harmful processes after injury, but your eligibility depends on specific brain-injury severity and monitoring needs.
LundAges 10–70 - NCT04331392Recruiting
Online memory training for people with recent brain injury
This trial tests an online memory program for people with a recent traumatic brain injury (TBI) to help with thinking and memory. It may be useful if your injury is recent and you can safely do MRI scanning.
Toronto, OntarioAges 18–55 - NCT04905264Recruiting
Studying factors and care quality after severe brain injury
This study looks at how outcomes and care quality vary for people with serious acquired brain injuries while in a rehabilitation unit. It may help clinicians understand what care works best and why.
AlessandriaAges 18 years+ - NCT05663034Recruiting
Compare CBT-I vs MBTI for sleep and trauma symptoms after TBI
This study compares two types of talk-based therapy to help veterans with long-lasting insomnia after a traumatic brain injury (TBI), and also looks at related post-trauma stress symptoms. It may help you improve sleep and reduce how much these symptoms affect daily life.
Eglin Air Force Base, FloridaAges 18 years+ - NCT04945213RecruitingPhase 3
Biperiden to prevent seizures after traumatic brain injury
This trial tests whether biperiden can lower the chance of developing epilepsy after an acute traumatic brain injury (with bleeding or bruising seen on CT). If you qualify, you would get the medicine or a placebo soon after the injury, and researchers will compare outcomes.
Fortaleza, CearáAges 18–75 - NCT05095857RecruitingPhase 4
Ketamine to improve care in severe acute brain injury
This Phase 4 trial tests whether giving ketamine during anesthesia is safe and helpful for adults with severe sudden brain injuries after surgery. It may improve how patients are sedated and cared for while they are on a breathing machine.
CopenhagenAges 18 years+ - NCT05261477Recruiting
Kid Brain Injury Education and Care Navigation Program
This trial tests a family support program that teaches caregivers and helps coordinate outpatient care after a traumatic brain injury. It may help families better understand recovery and connect with rehabilitation services.
Colorado Springs, ColoradoAges 3 years+ - NCT05307640Recruiting
Support for caregivers after moderate to severe brain injury
This study tests a caregiver-focused program to improve well-being for people caring for someone who recently had a moderate to severe traumatic brain injury. It may help caregivers feel better and cope more effectively during the early recovery period.
Cincinnati, OhioAges 18 years+ - NCT05393492Recruiting
Emotion and behavior skills after a brain injury
This study tests a structured program to help people after a brain injury manage emotions and challenging behaviors, and to reduce distress for them and their families. If you (or your family member) can participate safely and understand the activities in French, you may be invited to join a group and assessments.
Illkirch-GraffenstadenAges 18 years+ - NCT05622461Recruiting
Recovery support program for children after traumatic brain injury
This trial supports families during the early weeks after a child’s brain injury and hospital stay. It aims to help caregivers and children move toward recovery with better support after discharge.
Cincinnati, OhioAges 18 years+ - NCT05762796Recruiting
Brain scan and stimulation study for kids with mild concussion
This study tests whether a brain “stimulation” approach, paired with brain imaging (MRI), can help children who still have symptoms after a mild concussion. There is also a comparison group of children without concussion history.
Buffalo, New YorkAges 10–15 - NCT05848297Recruiting
Robotic ultrasound monitoring for severe traumatic brain injury
This trial tests whether a robotic system using a bedside ultrasound test (TCD) can safely monitor brain blood flow in adults with severe traumatic brain injury soon after the injury. It may help the care team track changes earlier and adjust treatment sooner.
Davis, CaliforniaAges 18 years+ - NCT05855252Recruiting
Study on monitoring and outcomes after moderate to severe head injury
This observational study follows adults with moderate to severe traumatic brain injury to understand care and outcomes. It collects information from the first 48 hours in the ICU and may help improve how clinicians monitor and treat patients in the critical early period.
Kogarah, New South WalesAges 18 years+ - NCT06062628RecruitingEarly Phase 1
Ketamine for severe traumatic brain injury
This study tests whether a low dose of ketamine can help people with severe traumatic brain injury by reducing brain pressure and improving oxygen levels. If you have a brain monitor in place and meet safety criteria, you may be able to join.
Dallas, TexasAges 18 years+ - NCT06062888RecruitingPhase 2/Phase 3
Testing fresh frozen plasma for traumatic brain injury
This trial tests whether giving fresh frozen plasma (a blood product) soon after a traumatic brain injury can help people recover better. It is for adults aged 18 to 65 with moderate to severe TBI confirmed by CT scan.
Chicago, IllinoisAges 18–65 - NCT06150196Recruiting
Brain health classes for veterans with TBI
This trial tests whether brain health and wellness classes can help veterans who have had multiple mild traumatic brain injuries and also have PTSD. The classes aim to improve cognitive symptoms like memory and attention.
Martinez, CaliforniaAges 18–75 - NCT06162091Recruiting
Understanding recovery after severe brain injury
This study is for adults who recently had a severe brain injury (within the last 3 months) and are in the early stages of recovery. Researchers want to learn more about what affects recovery and how to improve outcomes.
MessinaAges 18 years+ - NCT06177509Recruiting
Exercise therapy for mild traumatic brain injury
This trial tests if graded aerobic exercise can help people who have ongoing symptoms after a mild traumatic brain injury (concussion). It aims to see if carefully increasing exercise intensity improves tolerance to physical activity.
NesoddtangenAges 18–60
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Common questions
- Are there clinical trials for severe brain injury?
- Yes. Clin2 currently lists 270 recruiting severe brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.