Clinical trials
Sex Differences clinical trials
Below are recruiting sex differences clinical trials, each written for real people, not researchers. We’re tracking 28 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06832514RecruitingPhase 4
Gender and immune response to meningitis B vaccine
This study tests how well the meningitis B vaccine works in transgender and cisgender people. It aims to understand if sex and gender affect immune responses.
GhentAges 18–50 - NCT04948658Recruiting
Freezing ovarian tissue to protect future fertility
This study looks at storing ovarian (ovary) tissue by freezing it for people at higher risk of losing fertility. It may help preserve options for having biological children later, especially for certain genetic conditions, cancer-related risks, or planned gonad removal.
Bethesda, MarylandAges 2–35 - NCT03102554Enrolling by invitation
Study genes in sex development differences and hypospadias
This study looks for genetic causes of differences in how a baby or child’s sex organs develop, including hypospadias. You may be able to join if doctors can’t find a reason using standard testing.
Boston, MassachusettsAges Any age - NCT06840756RecruitingPhase 4
Does donor-patient sex matching improve blood transfusion outcomes?
This trial tests whether giving ICU patients blood from a donor of the same sex (male-to-male or female-to-female) leads to better recovery compared to mismatched transfusions. The goal is to see if matching donor and patient sex makes a difference in how well patients do.
Hamilton, OntarioAges 18 years+ - NCT06865950Recruiting
Sex differences in emergency stroke care
This study looks at how men and women with suspected stroke or mini-stroke are treated by emergency services. It aims to improve care for everyone.
HomburgAges 18 years+ - NCT07502391Recruiting
Family visits and delirium risk after surgery
This study looks at whether family visits after surgery can reduce the risk of confusion (delirium) in older adults. It helps us understand how social support affects recovery.
ZurichAges 65 years+ - NCT05332301Recruiting
Study of how men and women process a high-fat meal
This study looks at how the body’s metabolism changes after eating a high-fat meal, comparing differences between sexes. If you meet the health, diet, and medication rules, you may be asked to fast and have blood tests before and after the meal.
Hamilton, OntarioAges 18–35 - NCT06562777Recruiting
How symptoms differ between men and women during immunotherapy
This study looks at how symptoms during immunotherapy (a cancer treatment that boosts your immune system) may differ between men and women. Researchers will follow people with cancer who are starting immunotherapy to see if men and women report different side effects.
Portland, OregonAges 18 years+ - NCT03721822RecruitingPhase 1
Imaging how smoking affects lung inflammation in adults
This Phase 1 study uses special lung imaging to measure inflammation after different types of smoking or vaping. It looks at differences between people and may help researchers understand how smoking-related lung irritation develops.
Philadelphia, PennsylvaniaAges 18–45 - NCT06159608RecruitingEarly Phase 1
E-cigarette effects on blood vessels in young adults
This study looks at how e-cigarettes affect blood vessels in young adults. Researchers want to compare first-time vapers, experienced vapers, and non-vapers to see if there are differences between men and women.
Iowa City, IowaAges 18–24 - NCT07115849Recruiting
Sex hormones and exercise response
This trial tests how different sex hormone levels affect the body's response to physical training. It may help explain why exercise works differently for different people.
Aarhus, JutlandAges 18–35 - NCT03827460RecruitingPhase 1
Study tests how men and women respond to alcohol abstinence
This Phase 1 study looks at sex differences in how the body and brain respond when people stop drinking alcohol for a short time. You may be asked to complete questionnaires and provide blood samples to measure changes during the abstinence period.
Indianapolis, IndianaAges 21–35 - NCT04929288Recruiting
Study how hormones affect alcohol risk in men and women
This study looks at how brain activity and hormone-related factors may help explain differences in alcohol risk between men and women. It may help researchers understand why alcohol use differs by sex and how risk develops.
Columbus, OhioAges 21–26 - NCT05997732RecruitingPhase 4
Blood Pressure Control: Sex Differences in Healthy Adults
This study looks at how the nervous system controls blood pressure differently in men and women. It involves a single visit where you'll receive a small dose of medications through an IV and have your nerve activity and blood pressure measured.
Edmonton, AlbertaAges 18–40 - NCT06076551Recruiting
Sex differences in small blood vessel problems of the heart
This study looks at how small blood vessels in the heart work differently in men and women who have chest pain but no major blockages in their main heart arteries. The goal is to better understand and treat these smaller vessel issues.
SeoulAges 20–80 - NCT06261034Recruiting
How sex affects blood pressure control
This study looks at how the nervous system controls blood pressure differently in men and women. It may help researchers understand why some heart conditions affect men and women differently.
Rochester, MinnesotaAges 20–70 - NCT06426303RecruitingPhase 4
Alcohol Use Disorder Treatment in Veterans: Brain and Inflammation
This study is for veterans with alcohol use disorder who have been sober for 5 days to 3 weeks. It looks at how trauma, inflammation, and brain function relate to alcohol problems and how well treatment works. You will be in a group that gets medication or a placebo.
Portland, OregonAges 18–60 - NCT07692646Recruiting
Fasting's effect on fat burning and energy in cells
This study looks at how fasting changes the way your body burns fat and how cells produce energy. If you are a healthy adult of normal weight or living with obesity, you may help researchers understand the effects of fasting on metabolism.
CopenhagenAges 18–40 - NCT07692815Enrolling by invitation
Sex differences in response to strength training
This study looks at how men and women respond differently to resistance (strength) exercise. It may help you understand how your body adapts to training based on your sex.
Louvain-la-NeuveAges 18–40 - NCT06538948Recruiting
Eating behavior after weight loss surgery
This study measures how people eat and how their gut hormones change after weight loss surgery. It compares different groups to understand differences between men and women.
Männedorf, Canton of ZurichAges 18 years+ - NCT07122895RecruitingPhase 2
NMDA enhancer for negative symptoms in schizophrenia
This study tests whether a medication that boosts brain NMDA receptors can improve negative symptoms in schizophrenia, and looks at differences between men and women. It is for people with stable schizophrenia who still have mostly flat mood or low motivation.
TaichungAges 20–65 - NCT07214350Recruiting
Physical Activity Barriers in Cardiac Rehab by Sex
This study looks at how men and women differ in getting started and staying active during and after cardiac rehab. You will use a mobile app to track your activity and answer questions, helping researchers find better ways to support heart health.
Durham, North CarolinaAges 18 years+ - NCT07225777RecruitingPhase 2
THC's effects on brain and behavior by sex
This study looks at how THC affects men and women differently, focusing on brain activity and behavior. It may help understand why some people react differently to cannabis.
Charleston, South CarolinaAges 21–45 - NCT07297823Recruiting
How cold affects fat burning in men and women
This study looks at how your body's ability to burn fat during exercise changes when you are exposed to cold, and whether men and women respond differently. You will do two exercise tests in a cold room, and researchers will measure your fat burning.
Fort Collins, ColoradoAges 18–40
Hear when a new Sex Differences trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for sex differences?
- Yes. Clin2 currently lists 28 recruiting sex differences studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sex differences trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sex differences trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.