Clinical trials
Sickle Cell clinical trials
Below are recruiting sickle cell clinical trials, each written for real people, not researchers. We’re tracking 180 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04925492RecruitingPhase 1
PET scan study for vaso-occlusive crises in sickle cell disease
This Phase 1 study uses a special scan (PET) to better understand what happens in vaso-occlusive crises (pain episodes) in sickle cell disease. It may help researchers find ways to track or predict these crises using imaging.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05210114Recruiting
Skin hydration study in people with sickle cell
This study looks at how hydrated your skin is in people with sickle cell disease. It aims to better understand skin-related changes, which may help doctors monitor health and treatments in the future.
Pittsburgh, PennsylvaniaAges 12 years+ - NCT05336201RecruitingPhase 2
Brain training program for teens with sickle cell disease
This Phase 2 study tests a cognitive (thinking) training program to help teens with sickle cell disease prepare for the changes in their care as they grow older. It may help with skills like learning, attention, and planning for transition to adult care.
Birmingham, AlabamaAges 10–18 - NCT05359991Recruiting
Exercise study in children and teens with lung or blood conditions
This study tests how safe and effective a structured exercise program is for children and teens. It also compares results between children with sickle cell disease, cystic fibrosis, and healthy peers (and some teens after COVID-19 infection).
Irvine, CaliforniaAges 10–17 - NCT05414045Recruiting
Transplanting your own frozen testicle tissue for future fertility
This trial studies transplanting frozen testicular tissue back into the body to help restore fertility later. It is meant for people who preserved testicular tissue as children before cancer or a blood disorder treatment.
BrusselsAges 18–50 - NCT05431088RecruitingPhase 2/Phase 3
Tested treatment for teens and adults with sickle cell pain crises
This study tests a treatment in people with sickle cell disease who are having repeated pain crises. It may help reduce the frequency of these crises and is tailored for certain ages and crisis patterns.
New Haven, ConnecticutAges 12 years+ - NCT05685368RecruitingPhase 1/Phase 2
Therapy groups to help teens cope with sickle cell
This trial tests a structured talk-therapy program called Acceptance and Commitment Therapy (ACT) for teens and young adults with sickle cell disease. It aims to help you manage tough thoughts and feelings and cope with day-to-day challenges over 6 weekly group sessions.
Los Angeles, CaliforniaAges 14–21 - NCT05799118Recruiting
Genetic modifiers study for inherited blood disorders
This study looks at how your genes can affect inherited blood conditions like sickle cell disease and thalassemia. It may help researchers understand why symptoms differ from person to person, which could guide better future treatments.
Boston, MassachusettsAges 2 years+ - NCT05810181Recruiting
Interviews to improve choices about gene therapy for rare diseases
This study uses one-on-one interviews to learn what families and clinicians need to make decisions about gene therapy for rare diseases. The goal is to create or improve decision tools that make gene therapy information easier to understand and act on.
Memphis, TennesseeAges 8 years+ - NCT06035939Recruiting
SCD support study using mobile app
This trial tests a mobile app to help people with sickle cell disease manage their health. It's designed for those who have a compatible smartphone and internet access.
Charleston, South CarolinaAges 14–21 - NCT06147414Recruiting
Blood test for genetic disorders in pregnancy
This study tests a safer blood test to check for certain genetic disorders during pregnancy, instead of an invasive procedure like amniocentesis. It's for pregnant women who are at risk of passing on a known genetic condition.
ParisAges 18 years+ - NCT06213402Recruiting
European registry for rare anemia disorders
This study is creating a European registry (database) to collect information about people with rare anemia disorders. By joining, you help researchers better understand these conditions and improve care for yourself and others.
Barcelona, CataloniaAges birth–100 years - NCT06264700Recruiting
Helping patients take hydroxyurea as prescribed
This study tests whether video directly observed therapy (a caregiver or adolescent records themselves taking the medication) improves how consistently hydroxyurea is taken. It is for children with sickle cell disease (ages 1-10) or adolescents/young adults (ages 11-25) who have been prescribed hydroxyurea for at least 6 months.
Chicago, IllinoisAges 11 years+ - NCT06290401Recruiting
Boosting self-management in teens with sickle cell disease
This study is testing a program to help adolescents with sickle cell disease better manage their health. It looks at how family, friends, and the clinic can support teens to take charge of their care.
Wilmington, DelawareAges 13–21 - NCT06497153Recruiting
Lung ultrasound for children with sickle cell disease
This study tests whether using lung ultrasound can help doctors quickly spot and treat acute chest syndrome in children with sickle cell disease. It may lead to faster, safer care for kids in the intensive care unit.
ParisAges 1 month–17 years - NCT06526117RecruitingPhase 4
Stroke Prevention in Nigeria 2 Trial
This trial tests whether giving hydroxyurea (a medicine that helps prevent strokes) to children with sickle cell disease who have high-risk blood flow in their brains can stop strokes from happening. It's for kids in Nigeria who are at the peak age for stroke risk (5–12 years old).
KanoAges 5–12 - NCT06529874Recruiting
Pain, balance, and strength in children with sickle cell
This study looks at how children (ages 9-14) with sickle cell anemia or who are healthy handle pressure, balance, and strength. It aims to understand pain and movement better to help improve care.
GizaAges 9–14 - NCT06539169Recruiting
Following people with rare diseases over time
This study follows people with rare diseases over time to learn more about how these conditions progress and how they are treated. Joining may help researchers understand your disease better and find better ways to care for others.
Los Altos, CaliforniaAges Any age - NCT06773715Recruiting
Virtual reality for pain from sickle cell disease
This study tests if using virtual reality (VR) can help children and teens with sickle cell disease feel better during a severe pain episode. You would use VR while in the hospital to see if it reduces your pain.
New Orleans, LouisianaAges 8–21 - NCT06820515Recruiting
Blood disorder patient registry for all ages
This study is a registry (a large database) that collects information from people who have or may have a blood disorder. It helps researchers learn more about these conditions and improve care.
Hickory, North CarolinaAges Any age - NCT07116772Recruiting
Fertility experiences in sickle cell anemia
This study looks at fertility in people with sickle cell anemia. It aims to understand how the disease and its treatments affect fertility over time.
Santo DomingoAges 8 years+ - NCT07188766Recruiting
Different IV fluid amounts for sickle cell pain crisis
This study compares two ways of giving IV fluids (lighter vs. more fluids) to adults with sickle cell disease who are in the hospital for a painful crisis. The goal is to see which approach helps you feel better sooner.
Dammam, Eastern ProvinceAges 18–60 - NCT07206095Recruiting
Better diagnosis for inherited red blood cell diseases
This trial aims to improve how doctors diagnose rare inherited anemias, including sickle cell disease and other conditions that destroy red blood cells. It may help if you have a confirmed or suspected diagnosis but need more clarity through advanced testing.
Barcelona, BarcelonaAges Any age - NCT07373639Recruiting
Long-term follow-up after BEAM-101 treatment
This study is for people who have already received BEAM-101 in a previous study. It simply follows them over time to track their health and any long-term effects.
Birmingham, AlabamaAges 14–37
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Common questions
- Are there clinical trials for sickle cell?
- Yes. Clin2 currently lists 180 recruiting sickle cell studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sickle cell trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sickle cell trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.