Sleep Apnea Syndrome (OSAS) clinical trials

Tool to help decisions for mild sleep apnea in kids

This trial looks at OSA-18, a questionnaire that may help families and clinicians make better decisions about treatment for a child’s mild sleep apnea. It specifically focuses on children with enlarged tonsils and mild sleep study results.

CPAP registry for sleep apnea in people with high blood pressure

This study keeps a record of people with obstructive sleep apnea (OSA) who also have high blood pressure, to better understand how CPAP is used and what outcomes happen. It may help your care team by contributing your information to a large multi-center study in China.

Personalized tonsil surgery for sleep apnea in children with Down syndrome

This study tests whether a personalized surgical approach can treat moderate to severe obstructive sleep apnea (OSA) in children with Down syndrome. The goal is to improve breathing during sleep and overall sleep health.

Home sleep testing for children being checked for sleep apnea

This trial tests whether home sleep testing can help diagnose sleep apnea in children. It is for kids who are already being referred for an in-lab sleep study at CHOP.

Sleep apnea plus COPD study to check heart and breathing effects

This Phase 2 study looks at the cardiovascular (heart/blood vessel) effects of having both sleep apnea and COPD. It may help doctors better understand who is at risk and how to manage these breathing problems together.

Brain scan study in severe sleep apnea without CPAP

This trial uses a specialized brain scan (MRI) to study people with severe obstructive sleep apnea who are not using CPAP. It also compares them with people who do not have sleep apnea to understand how brain function differs.

Predicting teeth changes from sleep apnea mouthpiece treatment

This study looks at people with sleep apnea who are using a special mouthpiece (mandibular advancement device). It aims to find out which factors predict changes in how your teeth fit together after using the device.

CPAP treatment effects in older COPD and sleep apnea patients

This study looks at whether using positive airway pressure (often called CPAP) improves health outcomes in older adults who have both COPD and obstructive sleep apnea. It may help find ways to reduce symptoms and complications from “overlap” breathing problems.

Home Sleep Testing: Night-to-Night Measurement Variability Study

This study measures how sleep breathing patterns vary from night to night using home sleep testing. It helps researchers understand if portable sleep tests give consistent and reliable results.

Wall Squat Exercise for Blood Pressure in Sleep Apnea

This study tests whether a simple wall squat exercise can help lower blood pressure in people who have both high blood pressure and sleep apnea (treated with CPAP). If you are using CPAP regularly and are otherwise healthy enough to exercise, this trial may be a good fit for you.

Sleep apnea and COPD effects in older veterans

This study looks at how sleep apnea affects thinking skills and overall health in older veterans who also have COPD. It may help researchers understand what changes to target to improve daytime functioning and wellbeing.

Nasal spray treatment to reduce mild sleep apnea congestion

This study tests whether using oxymetazoline with fluticasone nasal spray can improve mild obstructive sleep apnea by lowering nasal congestion. If your nose stays blocked most days despite current spray use, this may help your breathing during sleep.

Start CPAP Therapy in Obstructive Sleep Apnea Patients After Atrial Fibrillation Ablation

A study of XW003 for obesity with sleep apnea (no CPAP)

This trial tests an investigational weekly injection called XW003 for weight loss in people who have obesity and moderate-to-severe sleep apnea but do not use a CPAP machine. It aims to see if the drug can help with weight loss and improve sleep apnea without the need for a breathing machine.

Study of XW003 for obesity with sleep apnea on CPAP therapy

This trial tests an investigational drug called XW003 to see if it helps people with obesity and obstructive sleep apnea who are already using a positive airway pressure (PAP) machine, like CPAP. It aims to improve weight loss and sleep apnea symptoms.

Personalized sleep apnea treatment for Down syndrome

This study tests if a treatment chosen based on your specific type of sleep apnea works better for people with Down syndrome. It looks for participants who have sleep apnea but are not already using a CPAP machine regularly.

Sleep Apnea Treatment with Dronabinol and Acetazolamide

This study tests a combination medication (dronabinol and acetazolamide) to treat obstructive sleep apnea in people who cannot tolerate or use CPAP machines. The goal is to find the right dose that safely reduces breathing interruptions during sleep.

Sleep patterns and recovery after first stroke

This study looks at how sleep affects recovery in people who have had their first ischemic stroke (a stroke caused by a blood clot). Researchers want to understand whether sleep quality influences how well patients regain function after stroke.

Breathing and throat muscle exercises for moderate sleep apnea

This trial tests whether strengthening your breathing and throat muscles can improve moderate sleep apnea. It aims to see if these exercises help reduce breathing pauses and improve sleep quality.

PMOS in OSA Pilot Study

Oxygen therapy for sleep apnea in Down syndrome

This study tests whether oxygen therapy can help children with Down syndrome who have sleep apnea. It compares oxygen treatment to no treatment to see if it improves breathing during sleep and thinking skills.

MASLD in Type 2 Diabetes in Primary Care - a Follow-up Study

Expanding the palate to help sleep apnea

This surgery expands the palate to treat obstructive sleep apnea caused by a narrow upper airway. It may help people with mild to moderate sleep apnea who have a specific type of airway collapse seen on a sleep-endoscopy test.

Better ways to adjust CPAP therapy when it isn't working well

This trial tests whether a wearable device called Sunrise can help doctors adjust your CPAP machine better than standard sleep tests. If your current CPAP isn't stopping all your breathing pauses, this study may help find the right adjustments for you.