Clinical trials
Smoking Cessation clinical trials
Below are recruiting smoking cessation clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05733767RecruitingPhase 2
Nurse-led help to quit smoking after heart or lung illness
This Phase 2 study tests a nurse practitioner–led program and medicine plan to help you stop smoking after certain heart or lung conditions. It may help you quit and stay smoke-free, while using lab testing (like breath measurements) to confirm progress.
Springfield, MassachusettsAges 18 years+ - NCT07826884Recruiting
Best times for a chatbot to help you quit tobacco
This study tests a WhatsApp-based chatbot that helps people quit tobacco. It is trying to find the best times to send you supportive messages, so you get more help and are more likely to succeed.
Hong KongAges Any age - NCT07441928Recruiting
Smoking and brain connections in schizophrenia
This study looks at how smoking affects brain networks in people with schizophrenia. It uses brain scans to see differences between smokers and non-smokers.
Hong KongAges 18 years+ - NCT05746442Recruiting
Interactive quitting messages for Khmer-speaking people with HIV
This trial tests whether interactive, personalized messages can help people who smoke cigarettes quit. It is designed for Khmer-speaking adults living with HIV and aims to support a quit attempt within about two weeks.
Phnom PenhAges 18 years+ - NCT04949464Recruiting
Smoking quit coaching plus lung scans for people with HIV
This study tests a behavior-change program to help people with HIV quit smoking, along with routine low-dose lung CT scans to find warning signs early. It’s a feasibility study, meaning the main goal is to see if the approach is practical and acceptable, and if people can follow through.
La Jolla, CaliforniaAges 45–80 - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT07301151Recruiting
Quit smoking study for Black adults in Minnesota
This study tests a smartphone app to help Black adults in Minnesota who smoke quit smoking. You'll use the app to track your progress and get reminders.
Minneapolis, MinnesotaAges 21 years+ - NCT06346028RecruitingPhase 4
TMS for quitting smoking
This study tests whether a brain stimulation therapy called transcranial magnetic stimulation (TMS) can help people quit smoking. It is for adults who smoke daily and are willing to try TMS as a treatment.
Toronto, OntarioAges 18–70 - NCT05846841Recruiting
Personalized quit-smoking support in primary care
This study tests a personalized tobacco (smoking) treatment plan delivered in primary care to help reduce cravings and smoking. It may help you quit or smoke less using options like nicotine patches/lozenges or varenicline, chosen to fit your needs.
St Louis, MissouriAges 18 years+ - NCT05513872RecruitingPhase 1/Phase 2
Help to quit smoking using nicotine replacement while not quitting yet
This early-stage study tests ways to help adults who currently smoke daily start making progress toward quitting (or changing smoking habits) over the next 6 months. You may use nicotine replacement, and the study checks safety for people who can use it.
Chicago, IllinoisAges 18 years+ - NCT07158749Recruiting
Imagining future events to help you quit smoking
This study tests a technique called episodic thinking—imagining future events in detail—to help people quit smoking. It may help you become more motivated to quit and reduce your urge to smoke.
Roanoke, VirginiaAges 21 years+ - NCT06713603Recruiting
Digital smoking cessation with motivational counseling
This study tests a digital program that uses personalized counseling over video or phone to help people stop smoking. It is for adults who smoke daily, have a primary care doctor, and can use a smartphone or computer.
San Francisco, CaliforniaAges 18 years+ - NCT01776398Recruiting
Donating breath, blood, and urine samples for lung research
This study collects airway samples (usually during a bronchoscopy), plus blood and/or urine, to help researchers study lung conditions. It may help advance understanding of lung disease and related biology, but it is not a treatment trial.
New York, New YorkAges 18 years+ - NCT05628389Recruiting
Phone-based help to quit smoking or waterpipe
This study offers phone support to help people quit smoking cigarettes and/or waterpipe. It may help you build a quit plan and get regular encouragement and coaching from a distance.
BeirutAges 18 years+ - NCT05154669RecruitingPhase 3
Coaching for quitting smoking and handling money worries
This Phase 3 study tests whether combining smoking-quit coaching with financial coaching helps people stop smoking and improve their finances. It may help if you smoke daily and also want support with money stress, while also checking that nicotine patch is safe for you.
New York, New YorkAges 18–100 - NCT00981396RecruitingEarly Phase 1
EFT therapy to help smokers who struggle to quit
This early-stage study tests Emotional Freedom Techniques (EFT), a gentle talking-and-tapping method, for people who feel very anxious about quitting and still have strong cravings. It may help improve confidence and reduce the emotional triggers that make quitting harder.
Ormskirk, LancashireAges 12–99 - NCT07098065Recruiting
Health warnings and counseling to help you quit smoking
This trial tests whether health warnings and counseling can help smokers quit. You'll get support during visits to your local pharmacy.
DhakaAges 18–90 - NCT06556238Recruiting
Smoking cessation trial for Alaska Native people
This study tests a personalized approach to help Alaska Native and American Indian people quit smoking. You will get treatment based on a blood test, and the study will see if this approach works better than standard care.
Anchorage, AlaskaAges 18 years+ - NCT05958667Recruiting
Quitxt texting program to help young adult smokers quit
This study tests whether a mobile text-messaging program (with web content/videos) can help young Latino adults quit smoking. You may qualify if you smoke regularly, want to quit, and can share follow-up information.
San Antonio, TexasAges 18–29 - NCT05836103Recruiting
Texting on your phone to help you quit smoking
This trial tests whether smartphone texting messages can help young adults stop smoking. If you’re planning to quit soon, the messages may support you during the quitting process.
Baltimore, MarylandAges 18–30 - NCT05008848RecruitingPhase 3
Text-based quit smoking program for rural cancer survivors
This trial tests a text message program to help people who have had cancer quit smoking. It is designed for those living in rural areas and aims to see if this program can support them in stopping smoking.
Kingman, ArizonaAges 18 years+ - NCT07501624Enrolling by invitation
Pharmacist-led tobacco treatment for HIV patients
This study works with pharmacists at six Ryan White HIV clinics to help people with HIV quit smoking or using tobacco. If you have HIV, are 21 or older, and have already met with a pharmacist about tobacco, you may be able to join.
Charleston, South CarolinaAges 21 years+ - NCT06678789Recruiting
Testing low vs high nicotine pouches for smokers
This study compares how low and high nicotine pouches affect adult smokers who want to try a tobacco-free option. You'll attend two visits in Charleston to check health markers.
Charleston, South CarolinaAges 21 years+ - NCT06678243Recruiting
Smartphone app to help occasional smokers quit
This study tests a smartphone app (SiS4) designed to help people who smoke occasionally but not daily to quit. You will use the app to track your smoking and get support tailored to your schedule.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for smoking cessation?
- Yes. Clin2 currently lists 148 recruiting smoking cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smoking cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smoking cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.