Stenosis clinical trials

Adjuvant Steroid Outcomes in Idiopathic Subglottic Stenosis

First-in-human test of a new TAVR valve for severe aortic narrowing

This trial tests a new heart valve replacement (TAVR) system in people with severe, symptomatic aortic stenosis. If you qualify, it may offer a less invasive option compared with open-heart valve surgery, while also helping researchers understand safety and early effectiveness.

Genetic changes in tracheal narrowing with two treatments

This trial studies genetic changes in people with tracheal stenosis (narrowing of the windpipe). It compares two treatments: wedge resection (cutting out the narrow part) and radial incision (cutting to open it up). This may help doctors choose the best treatment in the future.

Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis

Using a donated aortic patch to rebuild a child's windpipe

This trial tests a new way to repair a child's windpipe using a piece of donated aorta (a blood vessel) as a patch. It's for children who have severe breathing problems from a narrowed or damaged windpipe and cannot have standard surgery.

Drug-eluting stent for brain artery narrowing

This trial tests a drug-coated stent to treat severe narrowing in brain arteries. It may help reduce the risk of stroke in people with hardened arteries in the brain.

Steroid injections for back and pelvic pain

This study is testing how well and how safely steroid injections work for different types of back pain. If you join, you'll receive the injection as part of your care and fill out surveys about your pain and ability to do daily activities before and after.

Tracking heart health over time

This study uses a wearable patch to monitor heart-related signs in people with heart conditions. It aims to learn more about how these conditions progress, which could help improve future care.

Cle-pad study: Checking leg artery health in spine surgery patients

This study is looking at how common blockages in leg arteries (peripheral artery disease, or PAD) are in people who are having surgery for lumbar spinal stenosis or had surgery less than 3 months ago. If you qualify, it may help doctors better understand and treat this condition.

Heart scans for amyloidosis in people with severe aortic valve stenosis

This study looks at how often cardiac amyloidosis occurs in people with severe aortic valve stenosis. It uses different heart scans to find out more. If you have both conditions, this research may help doctors understand your situation better.

Comparing two treatments for narrowed neck arteries

This trial tests whether adding a PCSK9 inhibitor to a statin is better than a statin alone for people with mild-to-moderate narrowing of the carotid artery (the main artery in the neck). It looks at how well these treatments slow plaque buildup and prevent strokes.

Stent or procedure for narrowed carotid artery after neck radiation

This trial studies a carotid artery procedure (revascularization) to treat a major narrowing in the neck artery that happened after you had radiation for head or neck cancer. It may help prevent stroke risk by improving blood flow to the brain.

Directional preference in lumbar spinal stenosis

This study looks at whether people with lumbar spinal stenosis (a narrowing in the lower spine) have a 'directional preference'—a specific movement or position that eases their symptoms. If you have leg or buttock pain when walking, this trial may help find better ways to treat your condition.

Study of a new neck surgery for spinal stenosis

This study is looking at a new, less invasive neck surgery for people with cervical spinal stenosis (narrowing of the spinal canal in the neck). It tests whether this surgery helps relieve symptoms like pain, numbness, or weakness in the arms or legs.

Drug-coated balloon for blocked brain arteries

This trial tests whether a drug-coated balloon can safely open a severely blocked brain artery (at least 70% blocked) that remains symptomatic despite medication. It is designed for people who have not had a recent stroke or other major health problems.

Blood flow study after flow diverter for brain aneurysm

This study uses detailed 3D X-rays and ultrasound to understand how blood flows through a mesh tube (flow diverter) placed in a brain aneurysm. It may help doctors predict and prevent narrowing inside the tube.

Exercise program for people with narrowed neck arteries

This trial studies whether a supervised exercise program can improve mobility and balance in people who have narrowed carotid arteries in the neck but no stroke symptoms. If you fit the criteria, the goal is to see whether exercise helps your movement and safety without increasing risks.

Tracking symptoms in degenerative neck spine narrowing

This study follows adults with degenerative narrowing in the neck spine to see how symptoms and function change over time. It may help doctors better understand which patients improve or worsen, and why.

Early or delayed valve surgery for mixed heart valve disease

This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.

Smaller valve size approach versus standard valve size in TAVR

This trial compares a “smaller valve sizing” approach versus the usual sizing method during TAVR (a catheter-based valve replacement) for people with bicuspid aortic stenosis. The study aims to see which method improves safety and outcomes for the right valve fit.

Carotid artery narrowing treatment follow-up at clinic

This study follows people who are getting a procedure for carotid artery narrowing at the clinic. It aims to learn about outcomes after these treatments.

Compare two sites for dialysis catheter placement

This trial tests whether placing a dialysis catheter in one location (subclavian/near the collarbone) is as good as placing it in another (jugular/neck) for patients who need a temporary dialysis catheter. It aims to reduce problems like vein narrowing caused by catheter placement.

Stent vs. medication for narrowed kidney artery

This trial compares placing a tiny mesh tube (stent) to open the narrowed kidney artery versus continuing blood pressure medicines alone. It is for people whose high blood pressure is hard to control even with multiple medications and who have a blockage in the kidney artery that can be treated.

Open-door neck surgery plan for cervical spinal narrowing

This study looks at a more tailored and standardized surgical approach for people with neck spinal narrowing and spinal cord symptoms. It may help doctors compare and improve how well surgery works for different patients.