Stenosis clinical trials

Coated balloon for non-cancerous airway narrowing

This trial tests a special balloon coated with a medicine (paclitaxel) to open narrowed windpipes. It is for people whose windpipe is blocked by scar tissue from a ventilator, transplant, or other non-cancer causes, not from cancer.

European study on multiple and mixed valve disease

This study looks at people with multiple or mixed heart valve disease (moderate or severe) using echocardiography. It aims to learn more about how these conditions affect patients and help guide future care.

Comparing surgical approaches for lumbar spinal stenosis

This study is comparing two surgical approaches for patients with lumbar spinal stenosis (narrowing of the lower spine). It aims to see if a less invasive surgery works as well as a more extensive procedure, which may help patients recover faster.

AI helps diagnose low-gradient aortic stenosis

This trial is testing whether an artificial intelligence (AI) program can better identify low-gradient aortic stenosis, a type of heart valve narrowing, by looking at your echocardiogram (heart ultrasound). It aims to help doctors diagnose this condition more accurately without any extra procedures.

This Prospective Observational Study Aims to Evaluate the Capability of Ultra-high-resolution Photon-counting CT Angiography (UHR PCD-CTA) for Noninvasive Evaluation of Intracranial Venous Sinus Stents. The Study Will Compare Image Quality, Stent Visualization, Metal-related Artifacts, and Diagnosti

Treating rectal narrowing with a tube through the anus

This trial tests a procedure using a thin, flexible tube with a camera to fix a narrowing (stenosis) where the colon is reconnected after rectal cancer surgery. It may help people who have trouble with bowel movements due to this narrowing.

Carotid stent study comparing two stent positions using brain MRI

This study looks at how well a carotid artery stent works soon after the procedure, using special MRI pictures of the brain. It compares outcomes between stent placement closer to the top versus closer to the bottom of the narrowed area, to see which approach is safer for early brain effects.

Steroid injections to prevent tracheal narrowing from coming back

This trial tests if steroid injections into the windpipe can prevent narrowing from returning in people with idiopathic subglottic stenosis (a rare condition where the windpipe narrows for unknown reasons). If you have this condition and haven't had this type of treatment before, you may be able to join.

Stent-like device for blocked leg arteries in the thigh or knee

This trial studies a new stent-like vascular scaffold to improve blood flow in people with symptomatic blockage in the thigh/knee artery. It may help reduce symptoms from narrowed or blocked arteries, but you must meet several artery and health requirements.

Watchful waiting or TAVR for moderate aortic valve narrowing

This study compares regular monitoring (“clinical surveillance”) versus replacing the aortic valve using a minimally invasive procedure called TAVR for people with moderate aortic stenosis. It aims to see which approach better reduces symptoms or heart damage over time.

Tested blood pressure pills for mild to moderate aortic narrowing

This study tests whether angiotensin receptor blocker (ARB) blood pressure medication helps people with mild to moderate aortic stenosis (a narrowing of the heart’s main valve). It looks at safety and whether the treatment offers benefit for your heart and blood flow.

Test heart blood-flow measurements before and after TAVI

This study checks whether special heart tests can better understand “in-between” blocked heart arteries before and after TAVI (a valve replacement done through a catheter). It may help doctors choose the safest, most accurate treatment when coronary artery disease is unclear.

Testing whether one-level fusion is needed after lumbar decompression

This trial compares outcomes after decompression surgery for one affected area in the lower back, with and without adding spinal fusion. It may help patients avoid unnecessary extra surgery—or ensure fusion is used when it’s needed.

Registry for stent treatment in narrowed brain arteries in China

This study records outcomes for people with significant narrowing in brain arteries who have treatment using a drug-eluting stent. It may help doctors understand how well this approach works and what risks or benefits to expect.

Stenting branches to improve blood flow after certain heart repairs

This study looks at whether placing a small tube (stent) in a branch pulmonary artery can improve blood flow and heart function after specific childhood heart surgeries. It is meant for people who have d-TGA after ASO, or have ToF or TA, and need a branch PA intervention.

Future care for aortic stenosis

This research study is a registry that collects information about people with aortic stenosis, a condition where a heart valve becomes narrow. The goal is to learn more about how this condition is managed and to improve future care.

Lung ultrasound for better outcomes after heart surgery

This study tests whether using ultrasound to look at the lungs during and after heart surgery helps improve recovery. You may be eligible if you are having open-heart surgery with a heart-lung machine and meet certain health criteria.

Comparing coated and plain balloons for dialysis access narrowing

This trial tests whether a drug-coated balloon works better than a plain balloon to open up narrowed spots in your dialysis access. If you have a failing AVF with a narrowing that can be treated, this study may help improve your dialysis.

Stent for pulsatile tinnitus from narrowed head vein

This trial tests a special stent (a small mesh tube) placed in a narrowed vein in the head to stop a bothersome whooshing sound in the ear (pulsatile tinnitus) that hasn't gone away.

Comparing two surgeries for narrowed windpipe

This trial compares two surgical techniques to repair a narrowed windpipe caused by injury, trauma, or long-term breathing tube use. The goal is to find which approach works best for patients who need surgery for severe or moderate narrowing.

Studying windpipe tissue to understand non-cancerous narrowing

This study uses a small piece of tissue from your windpipe to look at the genes and cells that cause benign (non-cancerous) tracheal stenosis. It aims to understand why the narrowing happens, which could lead to better treatments.

Siegel Valve for Severe Aortic Stenosis (TAVR)

This study tests a new replacement valve called the Siegel, placed through a catheter in your leg (TAVR), for people with severe aortic stenosis. It aims to see if it is safe and effective for patients at low, intermediate, or high surgical risk.

Measuring Troponin T blood levels in aortic valve narrowing

This study looks at a blood test called high-sensitivity troponin T in people with aortic stenosis (a narrowed heart valve). The results may help doctors understand heart strain or risk in this condition.

Aortic Valve Calcium Score Study Using Heart Ultrasound

This study develops and tests a new way to diagnose severe aortic stenosis (narrowing of the aortic valve) by measuring calcium buildup on the valve using heart ultrasound. If you're already getting both an ultrasound and a CT scan of your heart, this study compares how well the ultrasound method can identify severe stenosis.