Clinical trials
Substance Use Disorders clinical trials
Below are recruiting substance use disorders clinical trials, each written for real people, not researchers. We’re tracking 422 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06617312RecruitingPhase 2
Cytisinicline and brain response to smoking cues
This study tests how a medicine called cytisinicline (similar to a plant-based stop-smoking aid) affects brain activity when you see or think about smoking. It may help researchers understand how the medicine works, even if you aren't ready to quit right now.
Los Angeles, CaliforniaAges 18–65 - NCT06639464RecruitingPhase 2
Semaglutide to help with opioid recovery
This trial tests if semaglutide, a medicine sometimes used for weight management, can help people recovering from opioid use disorder stay on track. It is for adults who have already started buprenorphine treatment and are ready to take part in a research study.
Boston, MassachusettsAges 18 years+ - NCT06695884Recruiting
Finding the best TMS pulse pattern to boost brain reward activity
This study tests different pulse patterns of transcranial magnetic stimulation (TMS), a noninvasive brain stimulation, to see which one best increases activity in brain reward circuits. It may help people who are dependent on nicotine.
Newark, New JerseyAges 18–55 - NCT06837220Recruiting
Smoking cessation program for people in community behavioral health
This study tests a smoking cessation program designed for people who receive care at community behavioral health centers in Chicago. If you're a daily smoker interested in quitting, you may be able to join and get support to help you stop.
Chicago, IllinoisAges 18–26 - NCT06786325RecruitingPhase 2
Psilocybin treatment study for opioid use disorder
This trial tests whether psilocybin can help people recovering from opioid use disorder while living at a residential treatment center. If you are already taking buprenorphine/naloxone (Suboxone), methadone, or have received Sublocade, this study may be an option for you.
Philadelphia, PennsylvaniaAges 18–60 - NCT06793488RecruitingEarly Phase 1
Anxiety and alcohol use disorder treatment study
This study tests whether a medication called disulfiram (Antabuse) can help people with alcohol use disorder (AUD) feel less anxious when they stop drinking. Researchers will also use brain scans (MRI) to look at how the brain changes during early abstinence.
New York, New YorkAges 21–55 - NCT06810310RecruitingPhase 2
Psilocybin for motivation in opioid use disorder
This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder stay motivated in recovery. It uses brain scans to see how psilocybin affects brain areas linked to motivation.
Philadelphia, PennsylvaniaAges 18–60 - NCT06822569Recruiting
Teen health choices & wellness study
This study tests a program to help teenagers make healthy choices. It may be a good fit if you've recently done a behavior you'd like to change and live in Rhode Island.
Providence, Rhode IslandAges 13–16 - NCT06837311Recruiting
Smoking cessation after stroke via smartphone monitoring
This study tests a smartphone-based program that helps people who recently had a stroke quit smoking. It uses digital monitoring and support as part of your regular post-stroke follow-up to lower the risk of another stroke.
BordeauxAges 18–80 - NCT06878287Recruiting
Bright light therapy for alcohol withdrawal
This study tests whether bright light therapy can help people going through alcohol withdrawal in a residential treatment center. It involves sitting in front of a bright light box for a set time each day, and may help reduce withdrawal symptoms and improve mood.
Paris, Île-de-France RegionAges 18–65 - NCT06899594RecruitingEarly Phase 1
Psilocybin for quitting methamphetamine
This trial tests whether psilocybin (a psychedelic medicine) can help people quit methamphetamine. You'll receive counseling before, during, and after the drug session, and your progress will be followed for several months.
Shreveport, LouisianaAges 25–65 - NCT06907979Recruiting
Cannabis use and emotion processing study
This study looks at how heavy cannabis use affects the way you process emotions. You may be able to join if you use cannabis most days, meet criteria for cannabis use disorder, and are not currently in treatment for it. Participants will have brain scans and mild brain stimulation.
Auburn, AlabamaAges 18–50 - NCT06940674RecruitingPhase 3
CBD plus opioid treatment for recovery
This study tests whether adding cannabidiol (CBD) to your usual methadone or buprenorphine treatment helps you recover from opioid use disorder. If you're already in stable treatment with those medications, the trial aims to see if CBD can improve your outcomes.
New York, New YorkAges 18–65 - NCT07075081RecruitingPhase 2
Cultural healing trial for Ojibwe adults using substances
This trial tests a culturally-based program called Gii'Igoshimong (Sitting With Your First Family) for Ojibwe/Anishinaabe/Chippewa adults who have used substances recently. It aims to support wellness and recovery in a way that respects your heritage.
Duluth, MinnesotaAges 18 years+ - NCT07085377Recruiting
Nurse-led methadone program for opioid use disorder
This trial tests a system where nurses can adjust your methadone dose without a doctor's order. It's for people starting methadone treatment for opioid use disorder and willing to be followed at a CSAPA center for 3 months.
BayonneAges 18 years+ - NCT07094061Recruiting
Brain response to reward cues in young adults
This study looks at how the brain reacts to cues that signal rewards in young adults ages 18 to 22. Participants will do computer tasks and have an MRI scan to understand differences in how people respond to reward-related signals.
Ann Arbor, MichiganAges 18–22 - NCT07118618RecruitingPhase 2
Probenecid for alcohol cravings and drinking
This study tests if the medication probenecid can help reduce cravings for alcohol and the amount you drink. It is for people who drink heavily and have moderate to severe alcohol use disorder.
Providence, Rhode IslandAges 18 years+ - NCT07341230Recruiting
Deep brain stimulation for alcohol addiction
This trial tests if deep brain stimulation can help people with severe alcohol addiction who haven't been helped by other treatments. It involves implanting a device to stimulate brain areas linked to addiction.
Cambridge, CambridgeshireAges 18–60 - NCT07592195Recruiting
Breathing and aerobic exercise for men in drug recovery
This study tests whether breathing exercises and aerobic exercise (like walking or jogging) improve physical and mental health in men recovering from substance use. You'd attend supervised exercise sessions twice a week for 8 weeks and complete health questionnaires.
LuzhouAges 18–50 - NCT06853873Enrolling by invitation
Alcohol counseling for safer pregnancies
This trial tests a counseling program to help pregnant women reduce risky alcohol use. The program is designed to support women in making healthier choices for themselves and their baby.
Cape TownAges 18 years+ - NCT06290778Enrolling by invitation
Mental health prevention training for fire fighter trainees
This study tests a program where peers teach emotion regulation skills to help prevent mental health issues in new fire fighters. You would be asked to complete surveys and attend training sessions.
Waco, TexasAges 21 years+ - NCT06173973Enrolling by invitationPhase 2/Phase 3
Ketone supplement for alcohol withdrawal symptoms
This study tests whether a special supplement (ketones) can help people feel better during alcohol withdrawal. It is for adults who are already in a treatment program for alcohol withdrawal.
Philadelphia, PennsylvaniaAges 18–75 - NCT03396276Enrolling by invitationPhase 4
Emergency system to help people stop opioid misuse
This Phase 4 study tests an “emergency opioid engagement system” that aims to help people who are opioid-dependent start stopping opioid use. If you’re willing to stop and can safely participate, the program may offer structured support when you’re in the emergency setting.
Houston, TexasAges 18 years+ - NCT06676059Recruiting
Substance use monitoring study with a smartphone app
This study uses a smartphone app and daily surveys to track alcohol or drug use. It aims to create a database for future research on addiction patterns and recovery.
Baltimore, MarylandAges 18–120
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Common questions
- Are there clinical trials for substance use disorders?
- Yes. Clin2 currently lists 422 recruiting substance use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.