Clinical trials
Supplementation clinical trials
Below are recruiting supplementation clinical trials, each written for real people, not researchers. We’re tracking 671 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06863194RecruitingPhase 1/Phase 2
Probiotics and kidney disease progression trial
This trial tests whether taking a probiotic supplement can slow down the decline of kidney function in people with moderate chronic kidney disease (CKD stages 3 and 4). If you have stable kidney disease and are not already taking probiotics, joining this study could help researchers find a new way to protect your kidneys.
Al Mansurah, DakahliyaAges 18 years+ - NCT07058922Enrolling by invitationEarly Phase 1
Beetroot powder for resistant hypertension
This study tests if a powdered beetroot supplement can improve blood flow in the small blood vessels of people with resistant hypertension. If you have hard-to-treat high blood pressure, this might be an option for you.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT07053657Recruiting
Vitamin D for heart health in overweight teens
This study looks at whether giving vitamin D can improve heart and metabolic health in overweight or obese teens who have low vitamin D levels. It may help lower risks like high blood sugar or cholesterol.
Anqing, AnhuiAges 10–16 - NCT07046845Recruiting
Prenatal Vitamin Study: Special vs. Generic for Moms with Food Insecurity
This study compares a special prenatal vitamin (Perelel) with a standard generic prenatal vitamin. It looks at how each affects the health of moms and babies, especially for those who have trouble getting enough nutritious food.
Pittsburgh, PennsylvaniaAges 14 years+ - NCT07035132Enrolling by invitation
Special supplement for patients with cancer at risk of malnutrition
This trial tests a special liquid supplement for patients with head, neck, lung, rectal, or esophageal cancer who are having radiation and are malnourished or at risk. The supplement is designed to be easier to digest if you have stomach or gut issues.
AlicanteAges 18 years+ - NCT06993103RecruitingPhase 4
Pasteurized donor milk for newborns of mothers with diabetes
This trial tests if giving pasteurized donor human milk to newborns of mothers with diabetes can help their health. It compares donor milk to regular baby formula as a supplement when extra feeding is needed soon after birth.
Brisbane, QueenslandAges birth–2 days - NCT06264570Recruiting
Personalized supplements for high homocysteine and cholesterol
This study tests a personalized approach based on your genes to choose the right natural supplements for people with high homocysteine and high LDL cholesterol. It aims to help lower these levels safely.
Novosibirsk, Novosibisk RegionAges 18–80 - NCT06965426Recruiting
Eye vitamins and skin test: a crossover study
This study tests whether a supplement containing lutein, zeaxanthin, and meso-zeaxanthin can increase the amount of these nutrients in your skin. You will take the supplement and a placebo at different times to see if there is a difference.
Kansas City, MissouriAges 18 years+ - NCT05723913Recruiting
Test functional foods on blood sugar and gut bacteria
This study looks at how eating specific functional foods affects blood sugar after meals and changes in gut bacteria. It may help people understand ways to support healthy blood sugar and digestion, but it’s not for people with diabetes.
Mexico City, Mexico CityAges 18–60 - NCT06895018Enrolling by invitation
Grape Drink Trial for Diabetes and Fatty Liver
This study tests a drink made from grape pomace (a natural byproduct) that is rich in polyphenols—compounds that may help the liver and heart. Participants have type 2 diabetes and mild fatty liver, and researchers want to see if the drink improves liver health, blood sugar, and gut bacteria over several months.
NaplesAges 35–70 - NCT06826924Recruiting
Fasting or ketones for prostate cancer
This trial tests whether a 7-day water-only fast or taking ketone supplements can help treat prostate cancer. You would have a biopsy before and after to see how the tumor responds.
Baltimore, MarylandAges 18 years+ - NCT06810440Recruiting
Preventing Anemia in Newly Married Women in Nepal
This study tests whether a program that combines group support and daily micronutrient supplements can help prevent anemia in newly married women in Nepal who are planning to become pregnant. It focuses on women living with their husbands and mothers-in-law.
KathmanduAges 18–25 - NCT06801886Enrolling by invitationPhase 3
Silymarin for better kidney transplant success
This trial tests if adding silymarin (a milk thistle extract) to standard anti-rejection medicines helps protect the new kidney from damage. It may improve how well the transplanted kidney works over time.
MartinAges Any age - NCT06749808Enrolling by invitation
Nutritional supplement study for wellness and nutrient absorption
This trial tests whether a nutritional supplement can improve wellbeing and help your body absorb nutrients better. It might be a good fit if you are generally healthy and not already taking high-dose carotenoid supplements.
Provo, UtahAges 20–65 - NCT06672952Recruiting
Citrus compound for exercise, blood flow, and stress in overweight adults
This study looks at whether a natural citrus compound called glucosyl-hesperidin (CitraPeak) can boost your exercise performance, improve blood flow, reduce stress, and sharpen thinking. Researchers want to see if it works differently for people who are moderately overweight or mildly obese.
Saint Charles, MissouriAges 18–50 - NCT06655454RecruitingPhase 2
Numbing medicine after root canal for pain relief
This study tests whether a long-acting numbing medication (bupivacaine) given after a root canal can reduce pain better than a standard short-acting numbing medicine. It is for people who need a root canal for a tooth that is causing sharp, constant pain.
New York, New YorkAges 18 years+ - NCT06559995RecruitingPhase 2/Phase 3
Ketone drink for alcohol withdrawal
This study tests whether a special ketone drink can ease alcohol withdrawal and help your brain heal. If you have been drinking heavily for at least 3 years and are having withdrawal symptoms now, this might be an option for you.
Philadelphia, PennsylvaniaAges 18–65 - NCT06507254Recruiting
Polyphenols and brain health in aging
This study tests whether eating more polyphenols (natural compounds in plants) can protect brain health in people at higher risk for Alzheimer's disease, especially if they currently eat a typical Western diet. Participants will be followed over time to see if changes in diet affect thinking and memory.
Los Angeles, CaliforniaAges 50 years+ - NCT06489873Recruiting
Lutein, Zeaxanthin, and Fish Oil for Macular Health
This study tests whether taking daily supplements of lutein, zeaxanthin, and fish oil can improve the protective pigment in your eyes. It may help people with low macular pigment and good vision who are not already taking high doses of these nutrients.
College Station, TexasAges 18–45 - NCT06433310RecruitingPhase 4
A dietary supplement's effect on gut fungi in healthy adults
This study tests whether a dietary supplement (L-phenylalanine) can affect the natural balance of fungi in the gut. Healthy volunteers take the supplement for a short time, and researchers check how it changes their gut fungi.
New York, New YorkAges 18 years+ - NCT06263660RecruitingPhase 2
Keto supplement for depression with inflammation
This study tests a keto-like supplement to see if it helps change how the brain responds to emotional situations in people with depression and higher inflammation. It involves MRI brain scans and blood tests.
Tulsa, OklahomaAges 18–65 - NCT06212427Recruiting
Preterm infant formula with human milk sugars
This study tests a special supplement added to preterm infant feeding. The supplement contains beneficial sugars found in breast milk, which may help babies digest better and grow. It is for premature babies who have started small feedings but are not yet fully feeding.
LinzAges birth–2 weeks - NCT06169241RecruitingEarly Phase 1
Nitrate supplement for resistant hypertension
This trial tests whether a natural nitrate supplement (like beetroot juice) can help lower blood pressure and improve blood vessel function in people with resistant hypertension. If you have resistant hypertension and your medications have been stable for at least 30 days, you may be eligible.
Rio de JaneiroAges 18–75 - NCT06044168Recruiting
Nutritional supplement for muscle growth in cerebral palsy
This study tests whether a nutritional supplement can help build muscle in children with spastic cerebral palsy. It may be a good fit if you have trouble with walking and have not had certain treatments recently.
Leuven, Vlaams-BrabantAges 4–10
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Common questions
- Are there clinical trials for supplementation?
- Yes. Clin2 currently lists 671 recruiting supplementation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a supplementation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a supplementation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.