Clinical trials
Surgical clinical trials
Below are recruiting surgical clinical trials, each written for real people, not researchers. We’re tracking 1,196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05462496RecruitingPhase 2
Pembrolizumab plus gut microbiome changes after pancreatic chemo
This Phase 2 study tests whether changing the gut microbiome (the gut’s helpful bacteria) and giving pembrolizumab after chemotherapy can improve outcomes for people with operable pancreatic cancer. It aims to see if this approach can boost the immune system after standard treatment and help reduce cancer returning.
New York, New YorkAges 19 years+ - NCT05822271Recruiting
Surgery first plus aligners to improve jaw alignment
This trial studies how well a treatment plan works when you start with jaw surgery and then use clear aligners for orthodontic (teeth/jaw) finishing. It may help people whose jaw growth/position problems are mainly due to the lower jaw being too far forward or the upper jaw being too far back.
Rio de JaneiroAges 17–35 - NCT05487391RecruitingPhase 3
QL1706 plus chemo after lung cancer surgery
This trial studies whether a study drug called QL1706 added to standard platinum chemotherapy can lower the chance of lung cancer coming back after surgery. It targets people with stage II to IIIB non-small cell lung cancer who have had their tumor fully removed.
ShanghaiAges 18 years+ - NCT05502380RecruitingPhase 3
Antibiotic prevention study for high-risk bone and spine surgeries
This Phase 3 study tests whether giving a broad set of preventive antibiotics before certain high-risk orthopedic surgeries lowers the chance of serious wound or bone infection. It mainly targets people who have contaminated wounds, tumor-related surgery, or known high-risk germs on the skin.
ZurichAges 18 years+ - NCT05516628RecruitingPhase 2
Adjuvant atezolizumab plus bevacizumab after liver cancer surgery
This trial studies whether adding atezolizumab and bevacizumab after complete liver cancer surgery can lower the chance the cancer comes back. It also uses “multi-omics” tests (special lab tests on your tissue/blood) to help predict who is more likely to respond or resist treatment.
SingaporeAges 21–90 - NCT05526417Recruiting
Prehab program before treatment for deep leg soft tissue cancer
This trial tests an individualized “prehab” program (exercises and preparation before treatment) to improve recovery and surgical outcomes for adults with deep soft tissue sarcoma in the leg. It’s meant to help your body be as ready as possible for radiotherapy and surgery.
Scottsdale, ArizonaAges 18 years+ - NCT05527145Recruiting
Non-surgical spacer for spinal stenosis causing leg pain
This trial tests a minimally invasive (“through the skin”) procedure that places a small spacer between back bones to relieve lumbar spinal stenosis symptoms like leg pain when walking. It may help people who still need surgery based on their symptoms and MRI findings but may be treated without open surgery.
RomeAges 50–85 - NCT05535166RecruitingPhase 2
Risk- and lab-guided treatment for young children with medulloblastoma
This Phase 2 trial tests how doctors choose treatment for infants and young children with newly diagnosed medulloblastoma, based on MRI/CSF staging and lab testing of the tumor. It may help by matching therapy intensity to the child’s specific risk level and tumor type.
Palo Alto, CaliforniaAges Up to 4.9 years - NCT05545007Recruiting
Pre-op vs post-op focused radiation for large brain metastases
This study compares giving focused, high-dose radiation before surgery versus after surgery for people with large brain metastases. The goal is to see which timing works best to control the tumors and help neurological outcomes.
Brescia, BresciaAges 18 years+ - NCT05554224Recruiting
Personalized treatment based on obesity-related fatty liver tests
This study uses multiple types of health data (“multi-omics”) to help choose a personalized treatment plan for people with obesity-related fatty liver disease. It may help match treatment to your biology to improve outcomes.
Reus, TarragonaAges 18 years+ - NCT05559411Recruiting
Tests ways to find different breast lesions before surgery
This trial looks at different methods doctors can use to locate a breast lesion using imaging, so it can be removed accurately during breast-conserving surgery. It may help your care team choose the best localization approach for your type and location of lesion.
LübeckAges 18 years+ - NCT05569681Recruiting
Two blood-thinner schedules for clot prevention in very obese surgery patients
This study compares two different schedules of bemiparin (a blood thinner) to prevent dangerous blood clots after surgery in people with very high body weight. It may help find the safest and most effective dose/timing for clot prevention around the time of surgery.
Erbil, Kurdistan RegionAges 18–90 - NCT05582265RecruitingPhase 3
Study immune drug plus chemo before surgery versus surgery first
This Phase 3 trial compares two treatment plans for stage III/IVA head and neck squamous cell cancer (HNSCC). One plan uses an immune drug with chemotherapy before surgery; the other goes straight to surgery first, to see which approach works better.
Guanzhou, GuangdongAges 18–80 - NCT05616988Recruiting
Study body-image improvement after breast cancer surgery
This study looks at how body image changes after mastectomy and breast reconstruction, and whether certain body chemistry patterns (called metabolomics) are linked to that change. It may help researchers understand what supports better body-image recovery after breast cancer.
Rome, RomeAges 18 years+ - NCT05626114RecruitingPhase 2
Study of a lab-made eye treatment after subretinal surgery
This Phase 2 study tests OpRegen, a treatment delivered during special eye surgery, for geographic atrophy related to age-related macular degeneration (GA from AMD). It also includes an imaging “substudy” that uses detailed pictures of your retina to better track safety and activity.
Beverly Hills, CaliforniaAges 50 years+ - NCT05671458Recruiting
Imaging guidance during head and neck tumor surgery plus radiation
This trial tests whether advanced imaging used during surgery can better guide where surgeons remove head-and-neck tumors. It also studies how this approach works alongside planned postoperative radiation therapy, which may be needed for more advanced tumors.
HeidelbergAges 18 years+ - NCT05672849Recruiting
Testing devices used during fetal surgery for spina bifida
This trial looks at how safe and effective certain surgical devices are when doctors perform a minimally invasive fetal procedure to repair a neural tube defect. If you choose this specific type of fetal surgery, you may be able to join the study to help improve care for future patients.
Houston, TexasAges 18 years+ - NCT05672368RecruitingPhase 2
Robotic surgery tool for abdominal and pelvic operations
This trial studies a specific robotic surgical system during abdominal and pelvic surgeries. It may help doctors improve how these operations are done using minimally invasive techniques (smaller cuts).
Duarte, CaliforniaAges 18 years+ - NCT05677269Recruiting
Compare surgery for bowel endometriosis versus IVF pathway
This trial studies whether surgically removing colorectal (bowel) endometriosis works better and is more cost-effective than choosing an IVF/ICSI treatment plan. It’s for people who want to get pregnant and are deciding between surgery and fertility treatments.
EindhovenAges 21–40 - NCT05679232Recruiting
Hydrogel coating to lower infection after hip replacement surgery
This trial studies whether a special hydrogel coating on a hip implant can reduce infections after hip revision surgery. If it works, it could help you heal with fewer post-surgery infection problems.
ViennaAges 18 years+ - NCT05679661Recruiting
Immunity-focused nutrition before surgery to reduce lung infections
This study gives an immunity-supporting nutrition plan and an oral cleaning product before and around surgery to help older adults avoid breathing-related complications. It is mainly for people at higher risk of post-surgery lung problems, and it checks whether the approach is safe and helpful.
BeijingAges 65 years+ - NCT05689255Recruiting
Study gut bacteria and gut chemistry after gallbladder treatment
This study looks at how your gut bacteria and gut chemical products change after treatment for gallstones. It may help researchers understand what drives symptoms and recovery after surgery and/or endoscopic procedures.
Singapore, SingaporeAges 21–80 - NCT05695924Recruiting
Surgery to reduce arm swelling after breast cancer
This trial studies whether a specific surgery (a lymph vessel transplant) can reduce upper-arm lymphedema in people who developed swelling after breast cancer treatment. You must already have tried standard therapy and still have persistent, mild-to-moderate swelling.
Stanford, CaliforniaAges 18–75 - NCT05696002Recruiting
Track outcomes after advanced pelvic cancer surgery
This study follows people who have advanced pelvic cancer surgery that removes more than one pelvic organ. It’s an observational study, meaning it mainly collects data to help improve how future surgeries and care are planned.
GlasgowAges Any age
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Common questions
- Are there clinical trials for surgical?
- Yes. Clin2 currently lists 1,196 recruiting surgical studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a surgical trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a surgical trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.