Clinical trials
Testosterone clinical trials
Below are recruiting testosterone clinical trials, each written for real people, not researchers. We’re tracking 51 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07568574Enrolling by invitation
Medical Study of Performance-Enhancing Substances in Elite Athletes
This study looks at how medically supervised performance-enhancing substances affect elite athletes' health and quality of life. Participants must be retired from professional sports and willing to undergo careful medical monitoring throughout the trial.
Abu DhabiAges 18 years+ - NCT06343870RecruitingPhase 3
Hormone implants for menopause after cervical cancer or early menopause
This trial tests hormone implants (estradiol and testosterone) to treat menopause symptoms in women who have had their ovaries and uterus removed due to cervical cancer, or who have early menopause. The implants are placed under the skin and may help with hot flashes, mood, and sexual health.
São Paulo, São PauloAges 18–60 - NCT04363164RecruitingPhase 2
Testosterone then enzalutamide to stop prostate cancer spread
This Phase 2 trial tests whether giving testosterone first, then enzalutamide (a prostate cancer hormone-blocking pill), can slow or prevent worsening metastatic prostate cancer. It is designed for men whose cancer progressed despite ongoing hormone-suppression treatment.
San Diego, CaliforniaAges 18–90 - NCT04049331RecruitingPhase 2
Testosterone therapy for cancer survivors with fatigue
This trial tests whether testosterone replacement can help male cancer survivors who have ongoing fatigue and low testosterone levels. It is for men who have completed chemotherapy or radiation and are cancer-free for at least a year.
Boston, MassachusettsAges 18–54 - NCT04460872RecruitingPhase 2
Testosterone plus walking training to support bones and muscles
This Phase 2 study tests whether testosterone therapy combined with walking training can improve bone and muscle health after a spinal cord injury. It aims to help men with low testosterone and walking problems by improving strength, body composition, and related health markers.
Gainesville, FloridaAges 18 years+ - NCT04833426RecruitingPhase 3
Testosterone levels around prostate surgery and recovery outcomes
This trial studies whether testosterone levels before and around radical prostate surgery affect cancer control and sexual/physical recovery. It may help doctors understand who benefits from testosterone replacement and who should not.
AmsterdamAges 18 years+ - NCT06733350RecruitingPhase 4
Testosterone therapy for low testosterone in men with low-risk prostate cancer
This study tests whether testosterone replacement therapy can safely improve low testosterone levels in men with low-risk prostate cancer who are not getting immediate treatment. It aims to help men feel better without worsening their cancer.
Buffalo, New YorkAges 18 years+ - NCT07476222Recruiting
Predicting testosterone decline in middle-aged men
This study looks at why testosterone levels drop in men aged 35-59. It may help identify early signs and ways to prevent it.
AndijanAges 35–59 - NCT06455969RecruitingPhase 4
Stress and recovery training study
This study looks at how the body handles stress, using different hormone levels to create specific conditions in healthy young adults. It aims to understand the body's response and recovery, which may help people build resilience to stress.
Pittsburgh, PennsylvaniaAges 18–40 - NCT06351501RecruitingPhase 3
Hormone treatment for gender dysphoria in teenagers
This study tests whether hormone therapy (such as testosterone or estrogen) helps reduce distress in teenagers who feel their gender does not match their body. It aims to see if starting hormones at this age improves mental well-being and overall quality of life.
ParisAges 13–14 - NCT03522064RecruitingPhase 2
HRD-positive advanced prostate cancer trial with androgen therapy and chemo
This Phase 2 study tests whether blocking male hormones (androgen therapy) plus the chemotherapy drug carboplatin can shrink advanced prostate cancer in men with specific DNA repair problems. It is for cases where prostate-specific antigen (PSA) is rising even though testosterone is already kept very low.
Sydney, New South WalesAges 18 years+ - NCT06188767Recruiting
Testosterone and muscle memory study
This study looks at whether taking testosterone can help muscles 'remember' past strength training. You may be able to join if you are healthy, don't smoke, and have not been lifting weights regularly in the last year.
CopenhagenAges 18–40 - NCT07476001RecruitingPhase 2
High-dose testosterone and PSMA-targeted radiation for prostate cancer
This trial tests whether a short course of high-dose testosterone followed by a radioactive drug (PSMA-617) can help men with advanced prostate cancer that has stopped responding to hormone therapy. The goal is to make cancer cells more sensitive to the radiation.
Tampa, FloridaAges 18 years+ - NCT07076771Recruiting
Testosterone and artery blockage in young men with heart disease
This study looks at whether testosterone levels are linked to how blocked the heart arteries are in young men (under 45) with early heart disease. It involves a one-time blood test during a planned cardiac catheterization.
SohagAges Up to 45 years - NCT05011383RecruitingPhase 2
High dose testosterone for prostate cancer with ATM, CDK12, or CHEK2 changes
This trial is testing whether high doses of testosterone can help treat advanced prostate cancer in men who have a specific genetic change (ATM, CDK12, or CHEK2). It is for patients whose cancer has stopped responding to current hormone therapies.
Aurora, ColoradoAges 18 years+ - NCT03851627RecruitingPhase 4
Testosterone for fatty liver in overweight men with diabetes
This trial compares testosterone undecanoate versus a placebo (inactive pill) to see if it lowers fat in the liver measured by MRI. It focuses on overweight or obese men who have prediabetes or type 2 diabetes and low testosterone confirmed by blood tests.
ViennaAges 18–75 - NCT03910738RecruitingPhase 2
Testosterone treatment for nerve protection and myelin repair in MS
This Phase 2 study tests whether taking testosterone (for low testosterone levels) can help protect nerves and repair myelin in people with relapsing-remitting multiple sclerosis (MS). It may be most relevant if your MS is stable and you have low blood testosterone without current androgen treatment.
BesançonAges 18–55 - NCT04798469RecruitingPhase 2
Testosterone to reduce long-term spine pain in men on opioids
This Phase 2 study tests whether taking testosterone can lessen chronic non-cancer spinal pain in men who have low testosterone while using opioid pain medicines. It may help by improving hormone levels that could be affecting pain and overall wellbeing.
Boston, MassachusettsAges 18 years+ - NCT06059118RecruitingPhase 2
High-dose testosterone and a drug for advanced prostate cancer
This trial tests a combination of high-dose testosterone with enzalutamide and difluoromethylornithine (DFMO) for men whose prostate cancer has spread and stopped responding to standard hormone therapy. It aims to see if this approach can shrink tumors or slow the cancer's growth.
Baltimore, MarylandAges 18 years+ - NCT06130449RecruitingEarly Phase 1
Testosterone and brain function in men with spinal cord injury
This study tests whether testosterone can help brain function in men with spinal cord injury and low testosterone. If you qualify, you would receive testosterone treatment and have your brain activity measured over about a month.
The Bronx, New YorkAges 18–80 - NCT06294990RecruitingPhase 4
Testosterone treatment for boys with Klinefelter syndrome in puberty
This trial tests if starting testosterone treatment during puberty (ages 10-14) helps boys with Klinefelter syndrome. It aims to understand how the hormone affects development and well-being.
CopenhagenAges 10–14 - NCT06487754Recruiting
Chronic pelvic pain in trans people on testosterone therapy
This study explores why some trans masculine people develop new or worsening pelvic pain after starting testosterone therapy. Researchers want to understand your experience through interviews.
Saint-Martin-d'HèresAges 18 years+ - NCT06670053Recruiting
Testosterone and brain development in teens
This study looks at how starting testosterone therapy affects brain development in transgender and gender-diverse youth. It may help you and your doctor understand the changes to expect.
Aurora, ColoradoAges 12–20 - NCT06689085RecruitingPhase 3
Testosterone replacement study for adolescent boys with low testosterone
This trial tests a testosterone injection (XYOSTED) to see if it's safe and effective for replacing testosterone in teenage boys who have low levels due to a known medical condition. It lasts 52 weeks, with an optional 2-year follow-up.
Los Angeles, CaliforniaAges 12–17
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Common questions
- Are there clinical trials for testosterone?
- Yes. Clin2 currently lists 51 recruiting testosterone studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a testosterone trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a testosterone trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.