Clinical trials
Tolerance clinical trials
Below are recruiting tolerance clinical trials, each written for real people, not researchers. We’re tracking 942 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07361237RecruitingPhase 1
HJ-004-02 tablet for EGFR-mutated lung cancer
This early-phase trial tests a once-daily tablet (HJ-004-02) for people with a specific type of lung cancer that has an EGFR mutation. It aims to see if the drug is safe and if it can shrink tumors when other treatments have stopped working.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05868876RecruitingPhase 1
Testing AK127 plus AK104 for advanced cancers
This Phase 1 study tests the safety and early anti-cancer activity of AK127 given together with AK104 in people with advanced solid tumors. You may be considered if standard treatments have already been tried or aren’t suitable for you.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07345364RecruitingPhase 1
Safety of single dose SIM0811 in healthy adults
This trial tests a single dose of an investigational drug called SIM0811 in healthy Chinese adults. The goal is to see if it's safe and how the body processes it, so researchers can find the right dose for future studies.
Jinan, ShandongAges 18–45 - NCT07347678RecruitingPhase 1
Safety study of RN5681 in healthy volunteers
This trial tests a new drug called RN5681 to see if it is safe and how the body processes it. It is for healthy people with certain cholesterol levels and may help people with high cholesterol or heart risk in the future.
Brisbane, QueenslandAges 18–65 - NCT07352423RecruitingPhase 1
Safety study of ALXN2230 in healthy volunteers
This trial tests the safety and how the body handles a new drug called ALXN2230 in healthy people. It helps find the right dose and checks for side effects.
LondonAges 18–65 - NCT07341464Recruiting
Blended tube feeding for children and adults
This study tests if a blended tube-feeding formula made from real food is easy to tolerate and acceptable for people who already use a gastrostomy tube. It may be a good option if you or your child need extra nutrition through a tube.
NottinghamAges 1 year+ - NCT07338838RecruitingPhase 1
Testing TQB3142 in advanced tumors
This trial tests a new drug called TQB3142 in people with advanced cancers that have not responded to standard treatments. The goal is to find a safe dose and see how the drug works in the body.
Guangzhou, GuangdongAges 18–75 - NCT07340424RecruitingEarly Phase 1
Study of 225Ac-TR2205 for triple-negative breast cancer
This trial tests a new radioactive drug called 225Ac-TR2205 for people with triple-negative breast cancer that has spread. The goal is to see if it is safe and tolerable. It may be an option if you have tried at least two other treatments, including one for metastatic disease.
Jinan, ShandongAges 18 years+ - NCT07340931Recruiting
Myopia-control spectacle lenses study for children
This study tests if special Essilor® spectacle lenses can slow down the progression of myopia (nearsightedness) in children. It aims to see if the lenses are comfortable and well-tolerated by young patients.
Nantes, NantesAges 6–16 - NCT06737224Recruiting
Fasting and exercise effects on immune health
This study looks at how a 48-hour fast, alone or combined with exercise, affects your immune system and blood sugar control. It may help explain how short-term fasting can improve health in active young adults.
Kelowna, British ColumbiaAges 19–35 - NCT06864975RecruitingPhase 4
Different doses of ADVATE for immune tolerance in boys with hemophilia A and inhibitors
This trial tests how different doses and schedules of the factor VIII medicine ADVATE can train the immune system to accept factor VIII again in boys with hemophilia A who have developed inhibitors. The goal is to find a better way to help their bodies stop blocking the treatment.
Beijing, Beijing MunicipalityAges birth–18 years - NCT07325136RecruitingPhase 1/Phase 2
BMS-986525 for Relapsed Small Cell Lung Cancer
This study tests a new drug called BMS-986525, alone or with other treatments, for people with small cell lung cancer that has come back or not responded to treatment. It aims to find out if the drug is safe and tolerable.
Detroit, MichiganAges 18 years+ - NCT07328451RecruitingPhase 1
Study of DNL628 for people with early Alzheimer's disease
This trial tests an experimental drug, DNL628, to see if it is safe and how it affects people with early Alzheimer's disease. It may help slow the disease by targeting a specific process in the brain.
's-HertogenboschAges 18–75 - NCT07326709RecruitingPhase 3
Votoplam for Huntington's disease: a Phase 3 study
This study tests an investigational drug called Votoplam for people with Huntington's disease. It aims to see if the drug can slow progression of symptoms like movement and thinking problems.
Birmingham, AlabamaAges 21–70 - NCT07330440Enrolling by invitationPhase 1
MRNA vaccine study for preventing genital herpes
This study tests a new mRNA vaccine designed to protect against herpes simplex virus type 2 (HSV-2), the virus that causes genital herpes. It is for healthy adults who have not had a genital herpes outbreak in the last 6 months.
BeijingAges 18–55 - NCT07325526RecruitingPhase 2
Testing an experimental drug for liver cirrhosis caused by MASH
This study tests an investigational medicine (BI 3802876) in people with early-stage liver cirrhosis due to MASH. The goal is to see if it is well tolerated and potentially helpful.
Chandler, ArizonaAges 18–75 - NCT07329894RecruitingPhase 1
XH001 and vaccine-activated T cells for advanced GI cancer
This trial tests a two-part treatment: an injection called XH001 plus a custom vaccine that trains your immune cells to attack tumors. It's for people with advanced stomach or bowel cancer that hasn't responded to at least two prior treatments.
BeijingAges 18–70 - NCT06867393RecruitingPhase 1
Safety study of HL-003 in healthy volunteers
This trial tests a new medicine called HL-003 in healthy people to see if it is safe and how the body processes it. You may join if you are generally healthy, between 18 and 50 years old, and meet specific health and lifestyle requirements.
Suzhou, JiangsuAges 18–50 - NCT07324434Enrolling by invitationPhase 1
Study of an oral tablet for healthy adults and those with high uric acid
This trial tests a new tablet (F-02-2-Na) to see if it's safe and how the body processes it. It's for healthy volunteers and people with high uric acid levels who may need long-term treatment.
Guangzhou, GuangdongAges 18–45 - NCT07321106RecruitingPhase 1
CBI-1214 for advanced colorectal cancer
This trial tests a new drug called CBI-1214, which is designed to help your immune system attack cancer cells. It is for people with advanced colorectal cancer that has not responded to other treatments.
Phoenix, ArizonaAges 18 years+ - NCT06869863RecruitingPhase 1/Phase 2
Study of MediReg® for severe male infertility
This study tests an experimental medicine called MediReg® for men with severe infertility who have not been able to conceive. It aims to see if the drug is safe and can improve sperm quality, possibly offering a new option for men who have not had success with other treatments.
Moscow, MoscowAges 21–60 - NCT07321366Recruiting
Cold therapy for muscle stiffness in cerebral palsy
This study tests a cold treatment called cryoneurolysis to reduce painful muscle tightness in the shoulder or elbow for people with cerebral palsy. It is for those who have tried other treatments like injections or medications and found they didn't work well or weren't an option.
Lyon, RhôneAges 12 years+ - NCT06707610RecruitingPhase 1
Testing a new drug for advanced solid tumors
This trial tests a new drug called ALK202 for people with advanced solid tumors that have not responded to other treatments. The study aims to see if the drug is safe and to find the best dose.
Margate, FloridaAges 18–75 - NCT07310134RecruitingPhase 1
Study of ZX-8177 for advanced solid tumors
This trial tests a new oral drug (ZX-8177) for people with advanced solid tumors that have stopped responding to standard treatments or cannot be treated with standard options. The goal is to see if it is safe and helps control the disease.
ShanghaiAges 18 years+
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Common questions
- Are there clinical trials for tolerance?
- Yes. Clin2 currently lists 942 recruiting tolerance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tolerance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tolerance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.