Clinical trials
Tolerance clinical trials
Below are recruiting tolerance clinical trials, each written for real people, not researchers. We’re tracking 952 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05418868RecruitingPhase 1
Long-acting cabotegravir injection safety in healthy adults
This Phase 1 study tests how the body handles a long-acting (slow-release) cabotegravir injection combined with a drug called hyaluronidase. It also checks safety and side effects in healthy adults to help future HIV-prevention or treatment plans.
Orlando, FloridaAges 18–55 - NCT05425810Recruiting
Smart tool to help check prosthetic socket fit
This study tests an easy-to-use smart system (called ENABLE) that helps assess whether a prosthetic socket fits your leg well. It may help improve comfort and reduce skin problems by making sure the socket fit is assessed in a consistent, affordable way.
Raleigh, North CarolinaAges 18–99 - NCT05428631Recruiting
Monitoring device tested in severe kidney and heart failure
This study checks how safe a small heart-pressure monitoring device is for people with advanced heart failure and severe kidney problems. It looks at whether doctors can continuously track heart filling/pressure to help manage symptoms and reduce risks.
Nîmes, GardAges 18–85 - NCT05430178Recruiting
Study of liver fat changes in kids with fatty liver disease
This study looks at how metabolism works in children and teens who have (or do not have) nonalcoholic fatty liver disease (NAFLD), a condition where fat builds up in the liver. Participants may include healthy-weight controls, obese controls without NAFLD, and kids with NAFLD who are already scheduled for a liver biopsy for clinical reasons.
Oklahoma City, OklahomaAges 10–20 - NCT05432362Recruiting
Energy sensing brain study in depression and weight groups
This study tests how the brain and body respond to “energy sensing” in people with depression and in people with different body weights. You may be asked to do assessments and follow specific health and diet rules so the researchers can compare groups.
Graz, StyriaAges 18–40 - NCT05436054RecruitingPhase 4
Plenvu vs Picoprep bowel prep for colonoscopy
This study compares two bowel-cleansing products (Plenvu and Picoprep) to see which works better and is easier to tolerate before a colonoscopy. It may help patients by improving the chance of a clear exam and reducing unpleasant side effects.
Aalborg, North JutlandAges 18 years+ - NCT05443178RecruitingPhase 1
Testing chloroquine added to tuberculosis treatment for safety
This Phase 1 study tests how safe and tolerable chloroquine is when given alongside standard tuberculosis medicine. It mainly involves healthy volunteers and helps researchers understand side effects and safe dosing.
ZurichAges 18–50 - NCT05469854RecruitingPhase 1
Study of linaprazan glurate in healthy volunteers
This study tests a new drug called linaprazan glurate in healthy adults aged 18 to 65. It looks at how the drug moves through your body and if it affects your heart rhythm.
UppsalaAges 18–65 - NCT05481879RecruitingPhase 1/Phase 2
Study medicine for DM1 to improve muscle function
This early-stage study tests DYNE-101 to see how safe it is and whether it can improve measurable muscle function in people with myotonic dystrophy type 1 (DM1). You may be asked to do several walking and strength tests and undergo heart and breathing screening measurements.
Stanford, CaliforniaAges 18–65 - NCT05518578RecruitingPhase 2
Drug trial for hard-to-control focal epilepsy with brain scar
This Phase 2 trial tests SPN-817 in adults whose seizures are still not well controlled despite trying multiple seizure medicines. It targets people with a specific type of brain finding called focal cortical dysplasia and looks at safety/tolerability and seizure outcomes over several weeks.
Jacksonville, FloridaAges 18–70 - NCT05527652Recruiting
Breathing tube device to help blocked upper airways in children
This study tests a self-supporting breathing tube placed through the nose during sleep to reduce upper airway blockage and improve breathing in children. It may help children who have sleep apnea symptoms, especially after tonsil/adenoid treatment or when tonsil removal isn’t possible.
Ann Arbor, MichiganAges 3–21 - NCT05528055RecruitingPhase 1
Safety study of SCR-6920 for advanced cancers
This Phase 1 trial tests whether SCR-6920 capsules are safe and tolerable in people with advanced, treatment-resistant cancers. It may help doctors learn the right way to dose the medicine and check for side effects.
Jinan, ShandongAges 18–75 - NCT05570422RecruitingPhase 1
Safety and early benefits of an injection plus radiation for cervical cancer
This Phase 1 study tests whether KRC-01, given by injection into the tumor, is safe and tolerable when combined with standard chemoradiation for locally advanced cervical cancer. It also looks for early signs that the treatment can shrink tumors.
ChandigarhAges 18 years+ - NCT05587205RecruitingPhase 1
Tested eye drops for safety in cataract patients with low cornea cells
This Phase 1 study tests how safe and tolerable an investigational treatment (EO2002) is in adults having cataract surgery. It also looks at whether the treatment can be given without causing harmful effects in people with reduced cornea cell counts.
Mexico City, Mexico CityAges 18 years+ - NCT05601726RecruitingPhase 1/Phase 2
Study of a new drug for hard-to-treat AML or high-risk MDS
This early study tests a new medicine (ABD-3001) to see if it’s safe and tolerable, how the body handles it, and whether it shows early signs of helping people with relapsed or hard-to-treat AML or high-risk MDS. It may be an option if standard treatments have already failed and you can’t receive a stem cell transplant.
Marseille, FranceAges 18 years+ - NCT05616793RecruitingPhase 1/Phase 2
Gene therapy eye surgery for LCA5 vision loss
This Phase 1/2 study tests the safety of putting a gene medicine into the eye for people with vision loss caused by LCA5 gene mutations. It includes a treatment group and a separate group of people who do not receive the gene medicine during the study.
Philadelphia, PennsylvaniaAges 4 years+ - NCT05620940RecruitingPhase 1
IV drug safety and absorption study in healthy men
This Phase 1 study tests two experimental medicines given by IV to healthy men. It checks safety and how the body absorbs and processes the drugs (their “pharmacokinetic” profile).
Herston, QueenslandAges 18–55 - NCT05621460Recruiting
Water carbonation and how well you tolerate standing up
This study tests whether drinking carbonated (fizzy) water changes how well your body handles standing up without feeling faint. If you are healthy and don’t have certain heart or nerve problems, you may be able to take part.
Burnaby, British ColumbiaAges 19–50 - NCT05629689RecruitingPhase 1
PET scan drug check for people with solid tumors
This Phase 1 study tests whether an investigational PET scan tracer is safe and tolerable when used for PET imaging in people with certain solid cancers. It mainly looks at side effects and how well the scan can be done, not whether it treats cancer.
AmsterdamAges 18 years+ - NCT05636579RecruitingPhase 1
Testing safety of multiple EO2002 eye drops for corneal swelling
This Phase 1 study tests whether EO2002 eye drops are safe and well tolerated in people with painful corneal swelling caused by the cornea’s inner lining not working well. It focuses on safety first, but your eye symptoms and vision may be monitored to see how you respond.
Mexico City, Mexico CityAges 18 years+ - NCT05639933RecruitingPhase 2
Topical cream for EGFR inhibitor skin rash in cancer patients
This Phase 2 study tests a topical cream (HT-001) to treat skin rashes caused by EGFR inhibitors. It aims to see whether the cream is safe and can reduce rash symptoms and discomfort.
Irvine, CaliforniaAges 18 years+ - NCT05644717RecruitingPhase 4
Testing erugliflozin for fatty liver and diabetes control
This trial studies whether erugliflozin can reduce liver fat and liver scarring (fibrosis) while also improving blood sugar in people with type 2 diabetes and fatty liver disease (NASH/NAFLD). It’s designed for people who haven’t used certain diabetes medicines like SGLT2 inhibitors or insulin before.
Peshawar, KPKAges 18–65 - NCT05648214RecruitingPhase 1/Phase 2
Testing a new liver medicine in people with fatty liver
This early-phase study tests whether ALN-PNP is safe and well tolerated, first in healthy adults and then in adults with MASLD (fatty liver disease). If you have MASLD, it may help researchers learn whether this medicine is a promising option for treating liver fat buildup.
Glendale, CaliforniaAges 18–75 - NCT05648591RecruitingPhase 4
Iloperidone study for teens with schizophrenia or bipolar I
This Phase 4 study checks how safe and well-tolerated iloperidone is when used in a typical, open-label way for teenagers. It may help doctors better understand side effects and safety in teens with schizophrenia or bipolar I disorder.
Little Rock, ArkansasAges 12–17
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Common questions
- Are there clinical trials for tolerance?
- Yes. Clin2 currently lists 952 recruiting tolerance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tolerance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tolerance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.