Clinical trials
Total Knee Replacement Surgery clinical trials
Below are recruiting total knee replacement surgery clinical trials, each written for real people, not researchers. We’re tracking 85 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06856356Recruiting
Robot-assisted knee replacement surgery study
This study tests if robot-assisted total knee replacement surgery is safe and effective. It may help people who need knee replacement surgery by using advanced technology for more precise implant placement.
Hefei, AnhuiAges 18–80 - NCT07319546Recruiting
Faster recovery after first knee replacement
This study tests a faster, more active recovery program for people having their first total knee replacement. It may help you get back to daily activities sooner after surgery.
Dali, YunnanAges 50–80 - NCT07275983Recruiting
Knee replacement recovery: spinal vs. general anesthesia
This study looks at recovery after total knee replacement surgery. It compares people who had spinal anesthesia (numbing the lower body) to those who had general anesthesia (being fully asleep) to see which group recovers better.
StrasbourgAges 18 years+ - NCT06891807Recruiting
Robotic vs augmented reality knee replacement
This study compares two advanced technologies for total knee replacement: a robot that uses a CT scan for guidance versus an augmented reality system that uses no scan. The goal is to see which approach leads to better outcomes for patients with osteoarthritis.
Sint-Martens-Latem, Oost-VlaanderenAges 18–85 - NCT06758297Recruiting
AI motivational talk after knee replacement
This study tests whether an artificial intelligence-guided motivational conversation can help reduce fear of moving after knee replacement surgery, and improve how much you can move.
Samsun, SamsunAges 18 years+ - NCT07239258Recruiting
Tele-rehab plan for knee replacement recovery
This study tests a special therapy plan delivered through video calls to help people recover after knee replacement surgery. It compares telerehabilitation to in-person therapy to see if it improves pain and movement.
Lahore, Punjab ProvinceAges 50–65 - NCT05992064Recruiting
Wearable sensors to track recovery after knee replacement
This study uses a small wearable sensor placed on your leg after knee replacement surgery to track your recovery. It helps doctors see how well you are moving and healing, without extra visits to the hospital.
Frederikshavn, North DenmarkAges 18 years+ - NCT07151417RecruitingPhase 2/Phase 3
Steroid injection during total knee replacement
This study tests whether adding a corticosteroid (a type of anti-inflammatory medicine) to the standard pain injection during total knee replacement can improve pain relief. It is for adults getting their first knee replacement at certain military hospitals.
Bethesda, MarylandAges 18 years+ - NCT07107581Enrolling by invitation
Exactech knee replacement follow-up study
This study is following patients who have or will receive an Exactech total knee replacement. It looks at how well the knee works over time and helps doctors understand long-term results.
DeLand, FloridaAges 18 years+ - NCT07058623Recruiting
Nurse-led telehealth vs in-person follow-up after knee replacement
This trial compares follow-up care with a nurse via video calls or phone versus in-person visits after your first total knee replacement. It aims to see if telehealth is as good as in-person for your recovery.
Hong KongAges 18 years+ - NCT07016243Recruiting
Knee recovery and ankle movement after knee replacement
This study looks at how well patients can move their ankle after knee replacement surgery and whether it affects their knee recovery. It may help improve rehabilitation for future patients.
Bagheria, PalermoAges 65–85 - NCT07023185Recruiting
Cold and compression after knee replacement
This study will test if adding cold and compression therapy after knee replacement surgery can help with pain, swelling, and recovery. You may qualify if you are 50 or older and having a knee replacement with a specific surgeon.
New Orleans, LouisianaAges 50 years+ - NCT07003932Recruiting
Remote monitoring after knee replacement surgery
This trial tests a remote monitoring program for people having knee replacement surgery. It uses a smartphone app to track your recovery, so you can stay in touch with your care team without needing extra clinic visits.
Oslo, Please SelectAges 50 years+ - NCT06929871Recruiting
Cementless vs. cementless knee replacement for osteoarthritis
This trial compares two types of knee replacements: one where the implant is glued in (cemented) and one where it locks into the bone without glue (cementless). It is for people with knee osteoarthritis who need a first-time total knee replacement.
LondonAges 18 years+ - NCT04677907Recruiting
Testing a metal knee implant feature in osteoarthritis surgery
This trial studies a specific type of knee replacement and how well it works after surgery for people with knee osteoarthritis. It may help doctors understand which implant approach leads to better outcomes and recovery.
Glasgow, ScotlandAges 18 years+ - NCT06880497Recruiting
Comparing knee sounds after two types of knee replacement
This study compares how much noise the knee makes (and how it feels to the patient) after two different kinds of total knee replacement surgery. It aims to help patients know what to expect after surgery.
AuxerreAges 18 years+ - NCT06768762Recruiting
Home activity program for knee replacement recovery
This study tests a home-based physical activity program for adults who have had a knee replacement at least a year ago. It aims to help you become more active with remote support and coaching.
Columbia, South CarolinaAges 18 years+ - NCT06687109Recruiting
Joint replacement surgery registry study
This study collects information from people having joint replacement surgery to track how they do over time and improve care.
Spokane, WashingtonAges 18 years+ - NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT06643845Recruiting
Can medical treatments delay or avoid knee replacement?
This trial tests whether a combination of non-surgical treatments can help people with knee osteoarthritis avoid or delay total knee replacement surgery. It may be an option if you are considering knee replacement but want to explore medical alternatives first.
AmiensAges 18–90 - NCT06596031Enrolling by invitation
Health coaching for people waiting for hip or knee replacement
This study tests whether health coaching can help people who are waiting for hip or knee replacement surgery. It aims to improve your health and wellbeing while you wait for your operation.
SheffieldAges 18 years+ - NCT06581965RecruitingPhase 4
Personalized blood clot prevention for hip or knee replacement
This trial compares a personalized approach to preventing blood clots after hip or knee replacement surgery with the standard one-size-fits-all method. The goal is to see if tailoring prevention to each patient works better and is safer.
Apeldoorn, GelderlandAges 18 years+ - NCT06290336Recruiting
Exercise and education before knee replacement surgery
This study tests if exercise therapy and patient education before total knee replacement can improve recovery. It may help people waiting for their first knee replacement due to osteoarthritis.
Linköping, Östergötland CountyAges 40–85 - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80
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Common questions
- Are there clinical trials for total knee replacement surgery?
- Yes. Clin2 currently lists 85 recruiting total knee replacement surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee replacement surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee replacement surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.