Clinical trials
Total Knee Replacement Surgery clinical trials
Below are recruiting total knee replacement surgery clinical trials, each written for real people, not researchers. We’re tracking 85 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05616884Enrolling by invitation
Cemented vs cementless partial knee replacement study
This study compares two ways of fixing a partial knee replacement: cemented or cementless. It may help doctors learn which method works better for patients with certain types of knee bone.
Alexandria, VirginiaAges 18–85 - NCT05516381Recruiting
Navigation-assisted knee replacement with two alignment methods
This study tests a computer-guided technique for total knee replacement and compares two ways of aligning the new joint. It may help improve how accurately the surgery is done, which could affect comfort and function afterward.
BarcelonaAges 18 years+ - NCT07080892Recruiting
Comparing two ways to give a knee nerve block for pain after knee replacement
This study compares two different ways of giving a nerve block (called iPACK) to see which works better for pain after total knee replacement. The goal is to find the best spot for the injection to help you feel more comfortable after surgery.
BratislavaAges 18–80 - NCT05805774Recruiting
Compare fixing versus replacing a fractured thigh bone
This study looks at the best surgical option for an acute (new) fracture of the lower thigh bone near a stable knee replacement. It compares surgery that “fixes” the bone versus surgery that “replaces” part of the bone to help you walk again safely.
Toronto, OntarioAges 65 years+ - NCT07775248RecruitingPhase 4
Long-lasting pain relief after knee replacement
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
Grosse Pointe Farms, MichiganAges 18 years+ - NCT06896240Recruiting
A smoothie supplement before and after knee revision surgery
This study tests whether drinking a special smoothie each day for 2 weeks before and after your knee revision surgery helps reduce inflammation and improve recovery. It is for people who have health conditions that cause inflammation, like diabetes or heart disease, and who are getting a knee replacement.
New York, New YorkAges 40–80 - NCT07276061Recruiting
Outpatient vs. in-hospital knee replacement recovery study
This study compares recovery after total knee replacement when patients go home the same day versus staying overnight in the hospital. It aims to see if outpatient surgery leads to similar or better recovery.
StrasbourgAges 18 years+ - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT06963320RecruitingPhase 2
Preventing blood clots after knee replacement with H001
This trial tests whether an experimental capsule (H001) can prevent dangerous blood clots after knee replacement surgery. It is for people who are scheduled for a first-time total knee replacement and are willing to take the study drug instead of standard blood thinners.
Shanghai, Shanghai MunicipalityAges 18–74 - NCT05459948Recruiting
Follow-up study for a primary knee replacement
This study tracks outcomes after a standard (first-time) total knee replacement using the GMK SpheriKA implant. It mainly looks at how well the knee works in everyday life, including activity and self-checks over time.
MérignacAges 18–80 - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT05685706Recruiting
Study of spine alignment after hip or knee replacement
This study looks at how the alignment of your spine relates to your walking and posture after hip or knee replacement surgery for wear-and-tear arthritis. It may help doctors better understand how to monitor recovery and long-term function.
Taichung, North DistrictAges Any age - NCT06911359RecruitingPhase 2
Anti-inflammatory vs. Prolotherapy for Knee Osteoarthritis
This study tests whether anti-inflammatory medications or dextrose prolotherapy (sugar water injections) can reduce knee pain and improve function in people with knee osteoarthritis. If you are a military healthcare beneficiary with moderate to severe knee pain, you may be able to join.
Travis AFB, CaliforniaAges 45–75
Hear when a new Total Knee Replacement Surgery trial opens
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Common questions
- Are there clinical trials for total knee replacement surgery?
- Yes. Clin2 currently lists 85 recruiting total knee replacement surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee replacement surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee replacement surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.