Clinical trials
Treatment as Usual clinical trials
Below are recruiting treatment as usual clinical trials, each written for real people, not researchers. We’re tracking 315 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03887559Recruiting
Group therapy for long-lasting trauma reactions in everyday clinics
This study tests a structured group program to help people manage long-lasting trauma-related symptoms such as feeling “on edge,” avoiding reminders, upsetting memories, strong emotions, or relationship problems. It may help you learn skills and stabilize symptoms while you continue care through regular outpatient clinics.
TrondheimAges 18–75 - NCT07263321Recruiting
Depression treatment choice in general practice
This study helps people with moderate depression decide between medication and therapy. Your doctor will work with you to pick the best option.
AalborgAges 18–65 - NCT07073066Recruiting
Lymphatic surgery for Alzheimer's disease (CLEAN-AD trial)
This trial tests a surgical procedure that connects lymphatic vessels in the neck to help clear waste from the brain in people with moderate-to-severe Alzheimer's disease. The goal is to see if this can improve thinking and memory.
Dongguan, GuangdongAges 50–80 - NCT07303608Recruiting
Tracking progress in social services to improve outcomes
This study looks at whether regularly checking in on your progress and giving feedback to your social worker can help improve the support you receive. If you are getting help from social services, you may be able to take part.
LinköpingAges 15 years+ - NCT07015944Recruiting
Moving on after breast cancer: a depression trial for survivors in Pakistan
This study tests a program called "Moving on After Breast Cancer" for women in Pakistan who have finished breast cancer treatment and now have depression. The goal is to see if this program helps them feel better emotionally.
Karachi, SindhAges 18 years+ - NCT06928480Recruiting
Unified Protocol for Emotional Health in Long COVID
This study tests a program to help people with Long COVID manage emotional difficulties like depression or anxiety. It combines different therapy approaches into one treatment, which you can receive online from home.
Zaragoza, ZaragozaAges 18 years+ - NCT06390462Recruiting
Counseling for teens in school-based primary care
This study tests a brief counseling approach called Interpersonal Counseling for Adolescents (IPC-A) in school settings. It aims to help teens with emotional or social challenges before they become more serious, and it's designed for those who aren't already in mental health treatment.
HämeenlinnaAges 13–16 - NCT05973786RecruitingPhase 3
Six-week medicine boost for bipolar depression after first treatment fails
This trial tests whether a stronger, more active medication plan for six weeks helps people with bipolar depression who did not improve with their first prescribed treatment. It compares the intensified medication plan to usual care to see which approach works better.
InnsbruckAges 18 years+ - NCT05973851RecruitingPhase 3
Six-week medicine boost for depression after first treatment failure
This study tests a more intensive antidepressant medicine approach for people whose first tried treatment didn’t work well enough. It compares the intensified treatment with usual care, aiming to improve depression symptoms and daily functioning.
InnsbruckAges 18–65 - NCT05969080Recruiting
Therapy program to support recovery after self-harm
This study looks at a treatment and recovery approach for veterans who have had recent non-suicidal self-injury. It may help by testing ways to reduce self-harm urges and support safer recovery over time.
Durham, North CarolinaAges 18 years+ - NCT05169385Recruiting
Parent support for teens in residential treatment for substance misuse
This trial tests a parent-focused program (via interviews and texting) for families when a teen is leaving residential treatment. It aims to help parents/guardians support their teen after discharge and reduce substance-related risk.
Rockford, IllinoisAges 12–18 - NCT07097142RecruitingPhase 3
Shorter radiation for bladder cancer with chemo
This trial tests if a shorter course of radiation therapy works as well as the usual longer course for people with bladder cancer who are also receiving standard chemotherapy. The goal is to see if shorter treatment can reduce side effects while still being effective.
Fort Smith, ArkansasAges 18 years+ - NCT06828640Recruiting
Vaginal dilator for menopause-related dryness
This trial tests whether using a vaginal dilator (a gentle, cone-shaped device) can help with vaginal dryness, burning, or pain caused by menopause or breast cancer treatments. It adds to your usual care.
Brussels, Brussels CapitalAges 18–85 - NCT05846841Recruiting
Personalized quit-smoking support in primary care
This study tests a personalized tobacco (smoking) treatment plan delivered in primary care to help reduce cravings and smoking. It may help you quit or smoke less using options like nicotine patches/lozenges or varenicline, chosen to fit your needs.
St Louis, MissouriAges 18 years+ - NCT06616584RecruitingPhase 2/Phase 3
Cemiplimab plus standard care for advanced lung cancer after prior treatments
This trial tests whether adding the immunotherapy drug cemiplimab to standard treatment can help people with advanced lung cancer that has already progressed after both platinum chemo and a prior immunotherapy. It is designed for those who responded to their first immunotherapy for at least 12 weeks before the cancer started growing again.
Daphne, AlabamaAges 18 years+ - NCT05890352RecruitingPhase 2
Add new medicines to standard treatment for returning lymphoma
This Phase 2 study tests whether adding tafasitamab, lenalidomide, tazemetostat, and zanubrutinib (along with standard lymphoma treatment) can improve outcomes in people whose large B-cell lymphoma has returned or not responded. It may help control disease more effectively and improve response duration for eligible patients.
Tucson, ArizonaAges 18 years+ - NCT07463807RecruitingPhase 1/Phase 2
Comparing two drug combinations for multiple myeloma that returned quickly
This study tests a new combination of two drugs, teclistamab and pomalidomide, against the usual treatment of three drugs for multiple myeloma that has come back shortly after a standard treatment. The goal is to see if the new combination works better or is safer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06577441RecruitingPhase 2
Adding enasidenib to usual care for higher-risk MDS with IDH2 mutation
This trial tests whether adding enasidenib (a targeted pill) to the standard chemotherapy (cedazuridine-decitabine) works better than the chemotherapy alone for people with higher-risk myelodysplastic syndrome (MDS) whose cells have a specific change in the IDH2 gene.
Berkeley, CaliforniaAges 18 years+ - NCT07299695RecruitingPhase 3
IVIG for sudden worsening of IPF
This trial tests whether giving a medication called intravenous immunoglobulin (IVIG) can help people with IPF who are hospitalized for a sudden worsening of their lung condition. The treatment aims to reduce inflammation and improve recovery.
PátraiAges 18 years+ - NCT06917911RecruitingPhase 2
Adding Venetoclax or Gemtuzumab to Chemotherapy for CBF-AML
This study tests adding a targeted drug (venetoclax or gemtuzumab ozogamicin) to standard chemotherapy for a specific type of acute myeloid leukemia (AML) called core binding factor (CBF)-AML. The goal is to see if the combination works better than chemotherapy alone.
Pembroke Pines, FloridaAges 18–59 - NCT06773936Enrolling by invitationPhase 2
Adding asciminib to usual care for adults with newly diagnosed Ph+ ALL
This trial tests if adding asciminib, a targeted pill, to standard treatment works better for adults newly diagnosed with a specific type of acute lymphoblastic leukemia (Ph+ ALL). It is for those who are older, or who cannot or choose not to have intensive chemotherapy.
Orange, CaliforniaAges 60 years+ - NCT06865040Recruiting
Inhaled treatment before lung cancer surgery to prevent lung complications
This trial tests whether giving an inhaled medication before lung cancer surgery helps prevent breathing problems after the operation. It is for people whose lung function is lower than normal, which puts them at higher risk for complications after surgery.
AmiensAges 18 years+ - NCT06647953RecruitingPhase 3
Testing a standard approach for pleuropulmonary blastoma, with or without topotecan
This trial compares a standard surgery and chemotherapy plan for type I pleuropulmonary blastoma (PPB) to adding the drug topotecan for types II and III PPB. The goal is to see if the extra drug helps shrink tumors and improve outcomes for children with more advanced disease.
Birmingham, AlabamaAges Up to 21 years - NCT04609046RecruitingPhase 1
Lenalidomide and nivolumab added to standard treatment for brain lymphoma
This Phase 1 trial tests adding two cancer medicines—lenalidomide and nivolumab—to the usual treatment for primary CNS diffuse large B-cell lymphoma (a type of lymphoma in the brain/spinal fluid). The goal is to see if the combination is safe and if it works better than the usual approach.
Los Angeles, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for treatment as usual?
- Yes. Clin2 currently lists 315 recruiting treatment as usual studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a treatment as usual trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a treatment as usual trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.