Clinical trials
Type 1 Diabetes Mellitus With Hypoglycemia clinical trials
Below are recruiting type 1 diabetes mellitus with hypoglycemia clinical trials, each written for real people, not researchers. We’re tracking 86 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05317455RecruitingEarly Phase 1
Studying brain sugar changes in adults with risky low blood sugar
This early-stage study looks at how the brain uses sugar in people with type 1 diabetes who have had severe or hard-to-notice low blood sugar. It may help researchers understand the brain effects of low blood sugar and guide safer care.
New Haven, ConnecticutAges 18–55 - NCT05363761RecruitingPhase 1
Artery procedure to treat type 2 diabetes and related problems
This Phase 1 study tests a new artery “ablation” procedure for people with type 2 diabetes, aiming to improve diabetes and related conditions like high blood pressure. It will also check whether the procedure is safe and works well enough to study further.
Panama CityAges 21–65 - NCT05369065RecruitingPhase 1
Artery ablation for type 2 diabetes with kidney and liver arteries
This Phase 1 study tests whether a minimally invasive artery procedure can improve type 2 diabetes and related health problems by targeting kidney and liver blood vessels. Because it’s early-stage, the main goal is safety and learning how the treatment works in people who meet specific diabetes, blood pressure, and blood test requirements.
TbilisiAges 21–65 - NCT05553093RecruitingPhase 4
Tirzepatide vs insulin for diabetes and brain effects
This study tests how tirzepatide and insulin glargine affect blood sugar, fat metabolism, and brain function in adults with type 2 diabetes. It may help researchers learn which treatment changes diabetes-related body and brain processes.
Nanjing, JiangsuAges 18–75 - NCT05822609RecruitingPhase 2
Semaglutide for kidney disease in adults with type 1 diabetes
This Phase 2 study tests semaglutide (a diabetes and weight-related medicine) to see if it can slow or improve diabetic kidney disease in people with type 1 diabetes. You may be able to join if you have type 1 diabetes for at least 5 years and ongoing signs of kidney damage measured in urine tests.
Aurora, ColoradoAges 18 years+ - NCT05887635Recruiting
RF treatment of the duodenum for type 2 diabetes control
This trial tests whether a procedure that uses heat energy (radiofrequency vapor ablation) applied in the first part of the small intestine (duodenum) can improve blood sugar control in adults with type 2 diabetes. It may help lower blood sugar when standard oral medicines are not keeping it in range.
SantiagoAges 18–65 - NCT06280703RecruitingPhase 1
Study of LY3938577 for type 1 diabetes
This study tests an investigational drug called LY3938577 in healthy people and people with type 1 diabetes. It looks at how the drug affects the body and whether it might help control blood sugar.
NeussAges 18–64 - NCT06297980Recruiting
Periods, blood sugar, and exercise in type 1 diabetes
This study looks at how your menstrual cycle affects your blood sugar and how you respond to exercise if you have type 1 diabetes. It aims to help women manage their diabetes better throughout the month.
Aurora, ColoradoAges 18–45 - NCT06325202Recruiting
A study on preventing low blood sugar with a closed loop system
This trial tests whether a closed-loop insulin pump combined with education can help people with type 1 diabetes better recognize and avoid dangerously low blood sugar. It may be a good fit if you've had diabetes for a long time and have trouble sensing when your blood sugar drops.
La Jolla, CaliforniaAges 18–75 - NCT06382350Recruiting
Blood sugar changes while driving with a closed-loop insulin pump
This study looks at how blood sugar levels change while driving in people with type 1 diabetes who use a closed-loop insulin pump (MiniMed 780G) compared to those who give multiple daily injections and use a continuous glucose monitor. The goal is to see which method helps keep blood sugar more stable during driving.
PragueAges 18 years+ - NCT06387199RecruitingPhase 2/Phase 3
Weekly semaglutide with closed-loop system for type 1 diabetes
This trial tests whether adding a weekly semaglutide injection (a GLP-1 drug) to a closed-loop insulin system can help reduce the need for carb counting in people with type 1 diabetes. It aims to improve blood sugar control and make diabetes management easier.
Montreal, QuebecAges Any age - NCT06425640Recruiting
Movement and Activity in Adults with Type 1 Diabetes
This study looks at how 24-hour movement patterns (like sitting, standing, walking, and sleeping) affect adults with type 1 diabetes. It may help you understand how your daily activities relate to your blood sugar control.
Ghent, East FlandersAges 25–50 - NCT06474598RecruitingPhase 2
Test of MTX228 for type 1 diabetes with some insulin
This study tests a new medication, MTX228, to see if it can help people with type 1 diabetes who still make some insulin. It may slow the loss of your own insulin production and improve blood sugar control.
Edmonton, AlbertaAges 18–65 - NCT06503809Recruiting
Ketogenic diet study for type 1 diabetes
This study tests if a very low-carb (ketogenic) diet is safe and helps control blood sugar in people with type 1 diabetes. You would follow the diet for a period and use a continuous glucose monitor to track your levels.
St Louis, MissouriAges 18–65 - NCT06575426RecruitingPhase 1/Phase 2
Testing pig pancreas cells for type 1 diabetes
This trial tests a treatment made from pig pancreas cells (OPF-310) to see if it's safe and can help people with unstable type 1 diabetes. The cells are meant to replace the insulin-producing cells your body has lost, potentially reducing dangerous low blood sugar events.
Chicago, IllinoisAges 35–65 - NCT06575478RecruitingPhase 2
Herbal granules for new type 2 diabetes patients
This study tests two herbal granules (Fuling Yunhua and Dihuang Baoyuan) to see if they help control blood sugar in people with type 2 diabetes who have not yet taken diabetes medication. You will be randomly assigned to one of the granules or a placebo for several weeks, and your blood sugar will be monitored closely.
BeijingAges 18–75 - NCT06609356RecruitingEarly Phase 1
Reducing high insulin levels in type 1 diabetes
This study tests if adding a non-insulin medication can lower the amount of insulin needed while improving heart and metabolic health in people with type 1 diabetes. It may also help understand how this approach works in people with a genetic form of diabetes (GCK-MODY).
Nashville, TennesseeAges 18–60 - NCT06731218RecruitingPhase 1
A study on RGB-5088 for type 1 diabetes
This trial tests a new treatment called RGB-5088 in people with type 1 diabetes. It aims to see if the treatment is safe and if it helps control blood sugar.
Tianjin, Tianjin MunicipalityAges 18–60 - NCT06739122RecruitingPhase 3
A study of dulaglutide for children with type 2 diabetes
This trial tests if a weekly injection of dulaglutide (Trulicity) can help children with type 2 diabetes control their blood sugar when used together with metformin and/or insulin. It may be an option for kids who are overweight.
Tucson, ArizonaAges 10–17 - NCT06748963Recruiting
Fasted exercise training for type 1 diabetes
This study tests if exercising before breakfast (while fasting) helps improve blood sugar control and heart health in people with type 1 diabetes. You'll continue using your insulin pump and glucose monitor, and attend supervised exercise sessions and MRI scans to measure changes in your body.
Edmonton, AlbertaAges 18–55 - NCT06912321Recruiting
Brain Circuit Study for Type 2 Diabetes
This study uses MRI scans to look at a specific brain circuit (the Papez loop) in people with type 2 diabetes. It aims to understand how diabetes might affect brain networks related to memory and emotion.
Nanjing, JiangsuAges 45–70 - NCT06921356Recruiting
Grocery delivery plus lifestyle program for high blood pressure and diabetes
This study tests whether a program that delivers healthy groceries along with lifestyle coaching can help people with high blood pressure and type 2 diabetes manage their conditions better. If you qualify, you'll receive support to improve your eating habits and health.
Baltimore, MarylandAges 18 years+ - NCT06945406RecruitingPhase 1
Study of an investigational drug for diabetes
This trial tests a new medicine, LY4057996, in people with type 1 or type 2 diabetes and in healthy volunteers. It aims to see if the drug is safe and how it works in the body.
NeussAges 18 years+ - NCT06966427Recruiting
Using a dosing app for insulin management
This trial studies a smartphone system that helps people with diabetes decide how much insulin to take. It is for people who use insulin injections or are starting basal insulin, and it uses a continuous glucose monitor to guide dosing.
Petah TikvaAges 6–75
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Common questions
- Are there clinical trials for type 1 diabetes mellitus with hypoglycemia?
- Yes. Clin2 currently lists 86 recruiting type 1 diabetes mellitus with hypoglycemia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a type 1 diabetes mellitus with hypoglycemia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a type 1 diabetes mellitus with hypoglycemia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.