Clinical trials
Type 1 Diabetes Mellitus With Hypoglycemia clinical trials
Below are recruiting type 1 diabetes mellitus with hypoglycemia clinical trials, each written for real people, not researchers. We’re tracking 87 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06820281RecruitingPhase 2
Tirzepatide effects on metabolism in type 1 diabetes
This trial tests whether tirzepatide, a medication that helps control blood sugar and weight, can safely improve how your body handles sugar when you have type 1 diabetes. The study looks at short-term effects and may help people who are overweight and use an insulin pump or automated system.
Sydney, New South WalesAges 18–70 - NCT06739122RecruitingPhase 3
A study of dulaglutide for children with type 2 diabetes
This trial tests if a weekly injection of dulaglutide (Trulicity) can help children with type 2 diabetes control their blood sugar when used together with metformin and/or insulin. It may be an option for kids who are overweight.
Tucson, ArizonaAges 10–17 - NCT06748963Recruiting
Fasted exercise training for type 1 diabetes
This study tests if exercising before breakfast (while fasting) helps improve blood sugar control and heart health in people with type 1 diabetes. You'll continue using your insulin pump and glucose monitor, and attend supervised exercise sessions and MRI scans to measure changes in your body.
Edmonton, AlbertaAges 18–55 - NCT06731218RecruitingPhase 1
A study on RGB-5088 for type 1 diabetes
This trial tests a new treatment called RGB-5088 in people with type 1 diabetes. It aims to see if the treatment is safe and if it helps control blood sugar.
Tianjin, Tianjin MunicipalityAges 18–60 - NCT06730906Enrolling by invitation
PACTAID app for managing exercise in type 1 diabetes
This study tests an app called PACTAID that helps adults with type 1 diabetes manage their blood sugar during exercise. You will try three different types of workouts to see how well the app works.
Rochester, MinnesotaAges 18–65 - NCT06609356RecruitingEarly Phase 1
Reducing high insulin levels in type 1 diabetes
This study tests if adding a non-insulin medication can lower the amount of insulin needed while improving heart and metabolic health in people with type 1 diabetes. It may also help understand how this approach works in people with a genetic form of diabetes (GCK-MODY).
Nashville, TennesseeAges 18–60 - NCT06575426RecruitingPhase 1/Phase 2
Pig pancreatic cell transplant for type 1 diabetes
This trial tests a new treatment made from pig pancreatic cells (called OPF-310) that are placed under the skin to help control blood sugar in people with type 1 diabetes. It is for those whose diabetes is difficult to manage and who have dangerous low blood sugar episodes.
Chicago, IllinoisAges 35–70 - NCT06503809Recruiting
Ketogenic diet study for type 1 diabetes
This study tests if a very low-carb (ketogenic) diet is safe and helps control blood sugar in people with type 1 diabetes. You would follow the diet for a period and use a continuous glucose monitor to track your levels.
St Louis, MissouriAges 18–65 - NCT06474598RecruitingPhase 2
Test of MTX228 for type 1 diabetes with some insulin
This study tests a new medication, MTX228, to see if it can help people with type 1 diabetes who still make some insulin. It may slow the loss of your own insulin production and improve blood sugar control.
Edmonton, AlbertaAges 18–65 - NCT06325202Recruiting
A study on preventing low blood sugar with a closed loop system
This trial tests whether a closed-loop insulin pump combined with education can help people with type 1 diabetes better recognize and avoid dangerously low blood sugar. It may be a good fit if you've had diabetes for a long time and have trouble sensing when your blood sugar drops.
La Jolla, CaliforniaAges 18–75 - NCT06297980Recruiting
Periods, blood sugar, and exercise in type 1 diabetes
This study looks at how your menstrual cycle affects your blood sugar and how you respond to exercise if you have type 1 diabetes. It aims to help women manage their diabetes better throughout the month.
Aurora, ColoradoAges 18–45 - NCT06046833Recruiting
Continuous glucose monitoring for diabetic gastroparesis
This study tests whether a continuous glucose monitor (CGM) can help manage blood sugar in people with diabetes and gastroparesis (slow stomach emptying). If you have type 1 or type 2 diabetes and stomach symptoms, this could help doctors better understand your glucose patterns.
Cleveland, OhioAges 18 years+ - NCT05822609RecruitingPhase 2
Semaglutide for kidney disease in adults with type 1 diabetes
This Phase 2 study tests semaglutide (a diabetes and weight-related medicine) to see if it can slow or improve diabetic kidney disease in people with type 1 diabetes. You may be able to join if you have type 1 diabetes for at least 5 years and ongoing signs of kidney damage measured in urine tests.
Aurora, ColoradoAges 18 years+ - NCT05762107RecruitingPhase 2
Drug ZT-01 to reduce low blood sugar at night
This Phase 2 study tests ZT-01 to help prevent night-time low blood sugar (hypoglycemia) in people with type 1 diabetes. It may help if you’ve had low blood sugar during sleep or are at high risk based on recent glucose monitoring.
Birmingham, AlabamaAges 18–75 - NCT01630850Recruiting
Islet cell transplant for brittle type 1 diabetes
This trial studies whether transplanting insulin-producing islet cells can improve blood sugar control and reduce severe low blood sugar in people with “brittle” type 1 diabetes. It’s meant for adults with long-standing insulin dependence and troublesome, hard-to-control hypoglycemia.
Chicago, IllinoisAges 18–70 - NCT05478707RecruitingPhase 2
Treating small blood vessel problems in type 1 diabetes
This study tests whether two different treatment strategies can improve the function of the tiny blood vessels in people with type 1 diabetes. It aims to find a way to prevent or reduce diabetes-related complications.
Orlando, FloridaAges 18–40 - NCT05317455RecruitingEarly Phase 1
Studying brain sugar changes in adults with risky low blood sugar
This early-stage study looks at how the brain uses sugar in people with type 1 diabetes who have had severe or hard-to-notice low blood sugar. It may help researchers understand the brain effects of low blood sugar and guide safer care.
New Haven, ConnecticutAges 18–55 - NCT04786262RecruitingPhase 3
A study of VX-880 and VX-017 for type 1 diabetes
This study tests two investigational drugs, VX-880 and VX-017, for people with type 1 diabetes who have trouble controlling their blood sugar and have frequent severe low blood sugar episodes. The goal is to see if these drugs can improve blood sugar control and reduce dangerous lows.
Duarte, CaliforniaAges 18–65 - NCT03746769RecruitingPhase 1/Phase 2
Testing gastrin to improve results of islet cell transplant
This trial looks at whether adding gastrin can improve outcomes after an islet cell transplant for people with type 1 diabetes. It may help some participants achieve better blood sugar control, but it also requires close follow-up and immune-suppressing medications to protect the new cells.
Duarte, CaliforniaAges 18–68 - NCT07659574RecruitingPhase 3
Study of UBT251 injection for type 2 diabetes not controlled by diet and exercise
This trial tests a new injected drug (UBT251) for people with type 2 diabetes who haven't been able to control their blood sugar with diet and exercise alone. It aims to see if the drug can help lower blood sugar levels safely.
Changsha, HunanAges 18–75 - NCT07568678RecruitingPhase 1
Testing HMS1005 in adults with type 2 diabetes
This study tests a new medicine called HMS1005 in people with type 2 diabetes. Researchers want to see how safe it is and how the body responds to different doses. You may qualify if you have type 2 diabetes that is either untreated or controlled with common diabetes medications.
Miami, FloridaAges 18–65 - NCT07502508RecruitingPhase 2
Icovamenib for type 2 diabetes with Ozempic
This trial tests an investigational pill called icovamenib for people with type 2 diabetes who are already on Ozempic but still have high blood sugar. The goal is to see if adding icovamenib helps lower blood sugar more safely.
Birmingham, AlabamaAges 18–70 - NCT07282639Recruiting
App-based diabetes education for type 1 diabetes
This study tests an app-based diabetes education program for people with type 1 diabetes. It aims to see if the app can help you manage your blood sugar levels better using insulin pens and a continuous glucose monitor.
Los Angeles, CaliforniaAges 18 years+ - NCT07803809RecruitingPhase 1
MWN105 injection for overweight and obesity
This study tests an investigational injection called MWN105 in people who are overweight or obese but do not have diabetes. The goal is to see if it is safe and helps with weight loss.
Kunming, YunnanAges 18–50
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Common questions
- Are there clinical trials for type 1 diabetes mellitus with hypoglycemia?
- Yes. Clin2 currently lists 87 recruiting type 1 diabetes mellitus with hypoglycemia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a type 1 diabetes mellitus with hypoglycemia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a type 1 diabetes mellitus with hypoglycemia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.