Clinical trials
Type 2 diabetes clinical trials
A condition where the body can’t use insulin properly, raising blood sugar. We’re tracking 1,059 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06278207Recruiting
Finerenone in real-world diabetes and kidney disease
This study looks at how the medication finerenone works in everyday medical practice for people with type 2 diabetes and certain stages of chronic kidney disease. It aims to see how safe and effective the treatment is outside of a clinical trial setting.
Multiple Locations, New JerseyAges 18 years+ - NCT06055036Recruiting
Stress reduction for heart health in Black men
This study looks at how reducing stress can improve cardiovascular health in Black men. It involves lifestyle changes and support to help lower your risk of heart disease.
Columbus, OhioAges 18 years+ - NCT06180837Recruiting
Can longer sleep improve heart health in overweight adults?
This study tests if getting more sleep (7+ hours) can lower certain fats in the blood called ceramides, which are linked to heart disease risk. It's for overweight adults who currently sleep less than 6.5 hours a night.
Salt Lake City, UtahAges 18–45 - NCT06143566RecruitingPhase 1/Phase 2
Polypill to prevent heart failure in diabetes and kidney disease
This trial tests a 'polypill' (a combination of several medicines in one pill) to prevent heart failure in people with type 2 diabetes and kidney disease. It may help reduce your risk of developing heart muscle problems.
Dallas, TexasAges 18–100 - NCT06120881RecruitingEarly Phase 1
Finding the Right Metformin Dose for Teens with Type 2 Diabetes
This study looks at how to give the right dose of metformin to young people with type 2 diabetes. If you join, you will wear a continuous glucose monitor for 6 weeks to help researchers find the best dose for you.
Oakland, CaliforniaAges 10–21 - NCT05000996Recruiting
Gut microbiome study for people having metabolic surgery
This study looks at your gut bacteria (your “microbiome”) around the time of metabolic surgery. It may help researchers understand how surgery affects gut health and related conditions like diabetes, blood pressure, and cholesterol.
Nashville, TennesseeAges 21–65 - NCT06078683Recruiting
Ketone drink for exercise and heart health in type 2 diabetes
This study tests whether a special ketone drink can improve exercise ability and heart function in people with type 2 diabetes. Participants will have two treadmill exercise tests and heart MRI scans to see how the drink affects their performance and cardiac efficiency.
Columbus, OhioAges 18–80 - NCT06003153RecruitingPhase 4
Gene and sugar response study with oral semaglutide
This study looks at how your genes affect your body's response to a diabetes medication called semaglutide. It may help people with slightly high blood sugar (pre-diabetes) understand why some respond better than others.
Boston, MassachusettsAges 18–65 - NCT05577390Recruiting
Comparing two treatments for diabetic nerve pain
This study compares two approaches to treating nerve pain caused by diabetes. You may be eligible if your diabetic neuropathy is moderate to severe and you can reliably use a phone for study steps.
Loma Linda, CaliforniaAges 45–85 - NCT05987410Recruiting
Nordic walking for weight and heart health after a cardiac event
This trial tests if a nordic walking program helps people with diabetes who are overweight or obese recover after a heart attack or heart procedure. If you had a heart event or stent/bypass in the last 3 months, this program could help you get stronger and manage your weight.
MilanAges 18 years+ - NCT05960656RecruitingPhase 1
Study of SGLT2 inhibitor effects on liver sugar production
This trial tests how stopping a type 2 diabetes medication called an SGLT2 inhibitor affects the liver's production of sugar and ketones. It may help understand better ways to manage diabetes.
San Antonio, TexasAges 30–75 - NCT05943626Recruiting
Sleep timing changes to improve heart and blood sugar health
This study tests whether changing your sleep habits can improve heart-related health and blood sugar control. You may be asked to follow a sleep schedule and other routines, and outcomes will be measured over time.
Salt Lake City, UtahAges 18–45 - NCT05933174Recruiting
Switching away from sulfonylureas in type 2 diabetes safety care
This trial helps patients and their primary care team consider safer alternatives to sulfonylurea pills for type 2 diabetes. It may help reduce risks from sulfonylureas by improving how treatment changes are discussed and supported in routine care.
Cleveland, OhioAges 45 years+ - NCT05933161Recruiting
Testing diabetes blood-sugar tracking for people with an LVAD
This study looks at how well people with an LVAD can manage their blood sugar when they use a continuous glucose monitor app on a smartphone. It may help your diabetes care team adjust treatment using more complete sugar data.
Rochester, MinnesotaAges 18 years+ - NCT05881447Recruiting
Study kidney disease patterns in people in Tanzania
This study looks at how common chronic kidney disease is, how it develops over time, and what risk factors are linked to it. It may help improve how kidney disease is recognized and managed in your community.
Bagamoyo, Coast RegionAges 18–99 - NCT05795439Recruiting
Plant-based nutrition program for adults with type 2 diabetes
This study tests whether a structured plant-based diet plan, weekly online classes, and keeping exercise routine steady can improve health in adults with type 2 diabetes. You may qualify if you’re able and willing to follow the program for the first 16 weeks.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05766488Enrolling by invitation
Testing continuous glucose monitor use in type 2 diabetes care
This study checks whether using a continuous glucose monitor (CGM, a sensor that tracks blood sugar) is practical and helpful for people with type 2 diabetes in primary care settings. It focuses on people who may have a harder time getting diabetes support and have higher A1c levels.
Omaha, NebraskaAges 19 years+ - NCT05663515Recruiting
Checks pancreatic cancer risk after starting exenatide in type 2 diabetes
This study looks at whether starting exenatide (a type 2 diabetes medicine) is linked to a higher or lower risk of pancreatic cancer compared with other similar diabetes medicines. It uses people’s prescription and medical record history to compare risks over time.
CopenhagenAges 18–99 - NCT05543083Recruiting
Therapy plus exercise for teens at risk of type 2 diabetes
This trial tests whether a combination of coaching (cognitive-behavioral therapy) and exercise can improve mood and help teens who are at higher risk for type 2 diabetes. It may be especially helpful if you’re dealing with depression symptoms and a family history of type 2 diabetes.
Aurora, ColoradoAges 12–17 - NCT05499702RecruitingPhase 2
Glucagon test after dieting in type 2 diabetes
This Phase 2 study tests how glucagon affects sugar and fat handling in the liver after a short period of calorie restriction. It may help researchers understand metabolic changes in people with type 2 diabetes and guide future treatments.
Rochester, MinnesotaAges 25–65 - NCT05427084RecruitingPhase 2/Phase 3
Canagliflozin to reduce inflammation in heart artery disease
This trial tests canagliflozin to see if it lowers “vascular inflammation” in people with diabetes and stable coronary artery disease. It may help reduce harmful inflammation signals that can raise future heart risk.
Ottawa, OntarioAges 18 years+ - NCT05354947Recruiting
Ultrasound test in adults with type 2 diabetes
This study tests whether a series of ultrasound treatments can improve blood sugar control in people with type 2 diabetes. You may be asked to stay on your current diabetes pills and avoid certain other medicines during the study.
New Haven, ConnecticutAges 21–75 - NCT05317585Recruiting
Continuous glucose monitor use during early pregnancy with type 2 diabetes
This study tests whether using a continuous glucose monitor during pregnancy is useful for people with type 2 diabetes. It may help track blood sugar levels more closely to support safer pregnancy care.
Worcester, MassachusettsAges 18 years+ - NCT05305287RecruitingPhase 4
Measuring liver energy use in people with diabetes and fatty liver disease
This study looks at how the liver uses energy (mitochondria) in people with type 2 diabetes and fatty liver disease. By understanding this, researchers may find better ways to treat liver problems.
San Antonio, TexasAges 18–80
Hear when a new Type 2 diabetes trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for type 2 diabetes?
- Yes. Clin2 currently lists 1,059 recruiting type 2 diabetes studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a type 2 diabetes trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a type 2 diabetes trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.