Treatment
Estrogen clinical trials
We’re tracking 77 recruiting studies that include Estrogen, each written for real people, not researchers, below.
Recruiting studies
- NCT06028022RecruitingPhase 2
Reishi mushroom for fatigue and joint/muscle pain in breast cancer
This trial tests whether a reishi mushroom extract can help reduce fatigue and joint or muscle pain in people with breast cancer who are taking aromatase inhibitors. If you have these symptoms, you may be able to join.
Albert Lea, MinnesotaAges 18 years+ - NCT05672901Recruiting
Silicone gel vs estrogen cream for menopause discomfort
This study compares a silicone gel with an estrogen vaginal cream to treat genital and urinary symptoms caused by menopause. It may help you see which treatment works better and is more comfortable for your symptoms.
Laguna Hills, CaliforniaAges 18 years+ - NCT05569577Recruiting
Extra hCG injections to help pregnancy in IHH
This trial studies whether adding extra hCG shots improves pregnancy outcomes for people diagnosed with IHH, a hormone-related cause of not starting periods. If you’re trying to get pregnant, it may help test whether this added treatment improves your chances.
Shanghai, Shanghai MunicipalityAges 18–45 - NCT05221021RecruitingPhase 4
Vaginal estrogen vs oral bladder medicine for overactive bladder
This study compares vaginal estradiol (a hormone placed in the vagina) versus an oral beta-3 medicine called mirabegron for overactive bladder symptoms. It looks to see which treatment works better and is safer for postmenopausal women.
Bethesda, MarylandAges 18 years+ - NCT06065748RecruitingPhase 3
New hormone therapy for advanced breast cancer after prior treatment
This trial tests a new oral hormone therapy, giredestrant, against a standard hormone therapy (fulvestrant) when both are given with a CDK4/6 inhibitor. It is for people with advanced ER-positive, HER2-negative breast cancer that has come back after initial hormone therapy, and who have not yet had other treatments for advanced disease.
Daphne, AlabamaAges 18 years+ - NCT06343870RecruitingPhase 3
Hormone implants for menopause after cervical cancer or early menopause
This trial tests hormone implants (estradiol and testosterone) to treat menopause symptoms in women who have had their ovaries and uterus removed due to cervical cancer, or who have early menopause. The implants are placed under the skin and may help with hot flashes, mood, and sexual health.
São Paulo, São PauloAges 18–60 - NCT07160504RecruitingPhase 4
Vaginal estrogen's effect on blood clotting in postmenopausal women
This trial tests if low-dose vaginal estrogen tablets affect blood clotting in postmenopausal women with vaginal atrophy. It includes women both with and without a past blood clot to see if the treatment is safe.
Aarhus NAges 50 years+ - NCT06159608RecruitingEarly Phase 1
E-cigarette effects on blood vessels in young adults
This study looks at how e-cigarettes affect blood vessels in young adults. Researchers want to compare first-time vapers, experienced vapers, and non-vapers to see if there are differences between men and women.
Iowa City, IowaAges 18–24 - NCT06745466RecruitingPhase 4
Stress, sleep, and hormones on heart health in midlife women
This study looks at how daily stress, sleep, and sex hormones affect blood vessel aging in women aged 40–55 who are still having regular periods. It may help understand why heart disease risk increases during this time.
Newark, DelawareAges 40–55 - NCT07010146RecruitingPhase 2
Estrogen's Effect on Bone Health in FHA
This study tests how estrogen treatment affects bone strength in young women with Functional Hypothalamic Amenorrhea (FHA), a condition where periods stop due to stress, low weight, or over-exercise. Participants who have had very few periods will receive estrogen to see if it improves bone density.
Charlottesville, VirginiaAges 14–30 - NCT06629233Enrolling by invitation
New immunotherapy targets for estrogen-receptor positive breast cancer
This trial tests a new technique to find unique targets on breast cancer cells that could be used for future immunotherapies. It focuses on women with estrogen-receptor positive primary breast cancer.
Ghent, East-FlandersAges 18 years+ - NCT06873971Recruiting
Laser plus vaginal estrogen for menopause symptoms
This trial tests if combining a special laser treatment with a vaginal estrogen cream can help relieve menopause symptoms like vaginal dryness, burning, and pain during sex. It may be a good option for women who have not used hormone therapy recently.
São Paulo, São PauloAges 45–70 - NCT05872204RecruitingPhase 2
Abemaciclib plus letrozole for rare ER-positive ovarian cancer
This trial tests whether abemaciclib with letrozole can slow or shrink certain rare ovarian cancers that have estrogen receptors. It may help people whose cancer has come back and can be measured on scans, with extra required tissue and blood tests.
Liège, LiègeAges 18 years+ - NCT06028555Recruiting
Study on safety of estetrol birth control pills
This study is tracking the safety of a new type of birth control pill containing estetrol (E4) and drospirenone (DRSP) compared to a standard pill. It will help doctors understand if this new option is safe for women who start using it.
Berlin, State of BerlinAges Any age - NCT06425978RecruitingPhase 4
Non-hormonal gel for vaginal dryness in menopause
This study tests a non-hormonal gel (called cellular matrix) to see if it helps with vaginal dryness and discomfort caused by menopause. It is for women who have these symptoms and want a treatment without hormones.
BarcelonaAges 18–70 - NCT06186271Recruiting
Safety of Estetrol Birth Control Pill Study
This study checks the safety of a newer birth control pill (E4/DRSP) compared to other common pills. It is for women who are just starting one of these pills.
Berlin, State of BerlinAges Any age - NCT07649356Recruiting
Estrogen and Muscle Function in Menopausal Women
This study compares how estrogen affects muscle strength and fitness in women before and after menopause. It aims to understand how hormonal changes during menopause impact physical health and may help researchers develop better support for women during this life stage.
AarhusAges 47 years+ - NCT06533865RecruitingPhase 3
Romosozumab and estrogen for bone loss from missed periods
This study tests whether a bone-building medication (romosozumab) combined with estrogen replacement therapy can improve bone density in young women with hypothalamic amenorrhea (missing periods due to low energy or stress). It aims to find a better treatment for low bone density caused by this condition.
Boston, MassachusettsAges 14–30 - NCT07617454Recruiting
Estrogen and Muscle Gain in Postmenopausal Women
This study looks at how estrogen affects muscle growth when postmenopausal women exercise for 12 weeks. Researchers want to understand whether estrogen plays a role in helping muscles develop stronger during strength training.
Aarhus, JutlandAges 40 years+ - NCT05283421Recruiting
Improving tests for abnormal cervical cells after menopause
This trial is looking at better ways to diagnose changes in the cervix in women after menopause. It may help by improving how doctors decide which cervical abnormalities need attention and follow-up.
RandersAges 50 years+ - NCT07340541RecruitingPhase 2
Personalized cancer therapy trial based on tumor markers
This trial tests new treatments that are chosen based on specific markers in your tumor. Researchers want to see if these personalized therapies work better than standard options.
New Haven, ConnecticutAges 18 years+ - NCT05457972RecruitingPhase 4
Using vaginal estrogen to support breastfeeding after delivery
This study tests whether using estrogen placed in the vagina after childbirth can help breastfeeding or milk pumping go more smoothly. It’s aimed at people who are at least 6 weeks postpartum and plan to breastfeed or pump.
Cleveland, OhioAges 18–50 - NCT06184750RecruitingPhase 2
Finding the best tamoxifen dose to lower breast cancer risk
This trial tests different doses of tamoxifen to find the best one for lowering breast cancer risk in premenopausal women. It aims to see if a lower dose works as well as the standard dose with fewer side effects.
Tucson, ArizonaAges 18–55 - NCT03011684RecruitingPhase 3
Preserve eggs using tamoxifen and letrozole during new breast cancer treatment
This study tests whether taking tamoxifen and letrozole (with fertility injections) can help people with newly diagnosed, estrogen-sensitive breast cancer preserve eggs before cancer treatment starts. It may help protect future fertility by collecting eggs early, before chemotherapy or other treatments begin.
San Francisco, CaliforniaAges 18–50
Common questions
- Are there clinical trials studying Estrogen?
- Yes. Clin2 currently lists 77 recruiting studies that include Estrogen, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Estrogen trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Estrogen an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Estrogen or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.