Treatment
Estrogen clinical trials
We’re tracking 77 recruiting studies that include Estrogen, each written for real people, not researchers, below.
Recruiting studies
- NCT04601116RecruitingPhase 3
Atorvastatin for hormone-positive breast cancer to prevent recurrence
This Phase 3 study tests whether taking atorvastatin (a cholesterol-lowering medicine) can improve outcomes for women with estrogen-receptor–positive breast cancer. It may help by affecting cancer-related pathways and reducing risk of recurrence or progression.
AarhusAges 18 years+ - NCT05020860RecruitingPhase 2
Study how early breast cancer responds on imaging and under a microscope
This Phase 2 study looks at how well early breast cancer shrinks with treatment and how that matches with what doctors find after surgery under the microscope. The goal is to learn better ways to predict and assess treatment success.
Houston, TexasAges 18 years+ - NCT05333328RecruitingPhase 4
Test of ovarian function suppression for low-risk premenopausal node+ breast cancer
This trial studies whether ovarian function suppression (a treatment that lowers hormone production from the ovaries) helps women with hormone-receptor positive, HER2-negative breast cancer that has spread to lymph nodes, but who have a low-risk result on a genomic test. It may help reduce breast cancer recurrence while avoiding more intensive treatment for those who are lower risk.
Seoul, KoreaAges 20–50 - NCT05846789RecruitingPhase 2
Chemotherapy with or without tocilizumab for breast cancer
This Phase 2 trial tests whether adding tocilizumab (a drug that targets inflammation signals) to standard chemotherapy helps people with triple-negative or ER-low metastatic or locally recurring breast cancer. It’s for adults who have had up to two prior treatments for metastatic disease and who can receive standard chemo.
Atlanta, GeorgiaAges 18 years+ - NCT05868226RecruitingPhase 1
Early cancer drug study for adults with advanced tumors
This Phase 1 study tests early (first-in-program) cancer medicines in people whose cancer has not been adequately controlled. It helps researchers learn the safest dose and early signs of whether the treatment may work for different tumor types and treatments.
Birmingham, AlabamaAges 18 years+ - NCT06072807RecruitingPhase 4
Brain imaging study for ER+ breast cancer with brain tumors
This trial tests a special PET scan called FES to see if it can detect estrogen receptors in brain metastases. It may help doctors better target treatment for people with ER+ breast cancer that has spread to the brain.
New York, New YorkAges 18 years+ - NCT06150898RecruitingPhase 2
Ketorolac and pregabalin for estrogen receptor positive breast cancer before surgery
This trial tests whether two medications, ketorolac (a pain reliever) and pregabalin (a nerve pain drug), can help treat estrogen receptor (ER) positive breast cancer when taken before surgery. It may offer better pain control and possibly improve cancer outcomes.
Brussels, Brussels CapitalAges 18–70 - NCT06264882RecruitingPhase 4
Study on ovarian suppression and body changes
This study looks at how temporarily stopping ovarian function affects weight, body fat, and blood vessel health in premenopausal women. If you qualify, you might help researchers understand the risks and benefits of short-term estrogen suppression.
Aurora, ColoradoAges 20–45 - NCT06357442Recruiting
Comparing progesterone methods for young people on estrogen therapy
This study compares two ways to give progesterone to young people on estrogen replacement therapy to see how they affect the lining of the uterus. It will help find which approach may be safer and more effective for your health.
Aurora, ColoradoAges 12–25 - NCT06401889Recruiting
Skin care program for breast cancer survivors on hormone therapy
This study tests whether a skin care program can improve the appearance of your skin and your quality of life while you take an aromatase inhibitor (a hormone therapy) after breast cancer treatment. It is designed for women who are starting this type of therapy for the first time.
Jacksonville, FloridaAges 18 years+ - NCT06439693RecruitingPhase 2
Sequential therapy for newly diagnosed HER2+ breast cancer that has spread
This trial tests a sequence of targeted therapies for people newly diagnosed with HER2-positive breast cancer that has spread to other parts of the body. The goal is to find a treatment plan that can potentially cure the cancer.
Boston, MassachusettsAges 18 years+ - NCT06474988Recruiting
Skin Changes in Breast Cancer Patients on Hormone Therapy or Chemotherapy
This study measures how your skin changes physically and mechanically during breast cancer treatment. It may help doctors better manage side effects like skin dryness or tightness.
MilanAges 40–70 - NCT06546397RecruitingPhase 1
Hormone therapy for uterine healing after abortion
This trial tests if taking estrogen and progesterone after an induced abortion helps the uterus heal better. It may reduce complications and support recovery.
Hangzhou, ZhejiangAges 18–40 - NCT06583408Recruiting
Very Early Estrogen and Ovulation Registry
This registry study is for people who have stopped getting periods due to a condition called functional hypothalamic amenorrhea, which may be linked to low estrogen and ovulation problems. Researchers want to track hormone patterns over time to better understand how the condition develops.
Jacksonville, FloridaAges 18–40 - NCT06713512Recruiting
Estrogen and its effect on lung tissue in obstructive lung disease
This study looks at how the hormone estrogen affects the lungs of people with asthma or COPD. It will help researchers understand why these diseases may be different in women.
LondonAges 18–99 - NCT06851754RecruitingPhase 3
Hormone therapy for teens with early menopause
This trial tests whether hormone replacement therapy (HRT) helps protect bone health in teenagers with premature ovarian insufficiency (POI). It compares HRT to a placebo and also includes healthy volunteers for comparison.
Bethesda, MarylandAges 11–19 - NCT06867484Recruiting
Breast re-irradiation after second lumpectomy
This trial tests whether giving a second round of radiation to the breast after a lumpectomy for a recurrence is safe and effective. It is for people with a specific type of breast cancer (ER+HER2-) who meet strict criteria regarding prior radiation and tumor characteristics.
Boca Raton, FloridaAges 40 years+ - NCT06969326RecruitingPhase 3
Estrogen cream after hysterectomy for transgender men
This study tests whether using a topical estrogen cream after hysterectomy surgery can help transgender men have a better recovery. Participants will be randomly assigned to use the cream or not, and researchers will follow up by text message.
Providence, Rhode IslandAges 18 years+ - NCT07053982Recruiting
New scan to find endometriosis spots
This trial tests a new type of PET/CT scan that uses a special tracer to find endometriosis lesions. It may help surgeons see exactly where the disease is, which could lead to more complete treatment.
ToulouseAges 18 years+ - NCT07222215RecruitingPhase 2
Capacitabine with or without elacestrant for ER+ breast cancer
This trial tests if adding a new oral targeted therapy (elacestrant) to standard chemotherapy (capecitabine) works better than chemotherapy alone for people with a specific type of advanced breast cancer that is hormone-sensitive (ER-positive) and has stopped responding to hormone therapy.
Boston, MassachusettsAges 18 years+ - NCT06062498RecruitingPhase 2
Elacestrant alone or with a CDK4/6 inhibitor for advanced breast cancer
This trial compares a new hormone therapy (elacestrant) to the same therapy combined with a CDK4/6 inhibitor (palbociclib, abemaciclib, or ribociclib) for people with a specific type of advanced breast cancer (ER-positive, HER2-negative) that has a mutation in the ESR1 gene. It aims to see if the combination works better than the single drug.
Chicago, IllinoisAges 18 years+ - NCT07262138Recruiting
Active monitoring for older women with early breast cancer
This trial studies whether active monitoring (watchful waiting) can be a safe option instead of immediate surgery or other treatments for women 70 and older who have a small, slow-growing type of breast cancer. If you join, you will not have surgery or other treatments right away, but your cancer will be closely watched.
Pittsburgh, PennsylvaniaAges 70 years+ - NCT07268183Recruiting
Estrogen changes and prolactinoma tumor size
This study looks at how changes in estrogen before diagnosis affect the growth of prolactin-secreting pituitary tumors (prolactinomas). The goal is to understand why some tumors are larger than others.
Bron, RhoneAges 18 years+ - NCT07361263Recruiting
Study of oxytocin response to oral estrogens
This trial looks at how the body's oxytocin level changes after taking estrogen pills. It includes healthy people and those with a condition called AVP-deficiency (a lack of a hormone that controls water balance). The study aims to understand how estrogen affects oxytocin.
BaselAges 18–50
Common questions
- Are there clinical trials studying Estrogen?
- Yes. Clin2 currently lists 77 recruiting studies that include Estrogen, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Estrogen trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Estrogen an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Estrogen or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.