Treatment
Oxycodone clinical trials
We’re tracking 34 recruiting studies that include Oxycodone, each written for real people, not researchers, below.
Recruiting studies
- NCT07813026RecruitingPhase 4
Combining gabapentin and oxycodone: abuse effects in recreational users
This study looks at how the combination of gabapentin and oxycodone affects feelings of reward or abuse (like euphoria) in healthy people who have used opioids recreationally. It helps understand if this combination might be more or less abusable.
Overland Park, KansasAges 18–55 - NCT07153003Enrolling by invitationPhase 4
Tramadol and oxycodone vs oxycodone alone for joint pain
This trial tests if taking two pain relievers (tramadol and oxycodone) together works better than oxycodone alone to control pain after knee or hip replacement surgery. It aims to find a more effective way to manage pain with fewer side effects.
Rochester, MinnesotaAges 18 years+ - NCT05761860RecruitingEarly Phase 1
Oxytocin to lower opioid misuse risk and pain in older adults
This early-phase study tests whether oxytocin (a hormone-like medication) can reduce how “appealing” opioids feel and also reduce pain. It’s aimed at older adults who have used opioids before but are not currently dealing with chronic pain most days.
Gainesville, FloridaAges 45–85 - NCT04218409RecruitingEarly Phase 1
Tests a spray to reduce opioid use and pain
This early trial studies whether Syntocinon can lower pain and help reduce how much opioids people use. It checks safety and the best dose by giving participants the study drug under close medical monitoring.
Gainesville, FloridaAges 21–45 - NCT07709598RecruitingPhase 2/Phase 3
HL-1186 for pain after abdominal surgery
This study tests a new painkiller called HL-1186 for people having abdominal surgery. If you qualify and enroll, you will receive the drug after surgery to see if it safely helps reduce your pain better than a placebo (a pill with no medicine).
Chengdu, SichuanAges 18–75 - NCT07699601RecruitingPhase 2/Phase 3
Testing a pain tablet after orthopedic surgery
This trial tests an investigational tablet called HL-1186 for controlling pain after orthopedic surgery. It explores whether the drug can safely reduce moderate to severe pain when given after the procedure.
Changsha, HunanAges 18–75 - NCT07651722Recruiting
Pain control and gut recovery after abdominal surgery
This trial tests a combination of two pain-management approaches—a long-acting numbing medicine injected near nerves and a self-administered opioid—to see if they help your gut function better and control pain after bowel or colon surgery.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT07434427RecruitingPhase 4
Buprenorphine vs. oxycodone for pain after lung surgery
This study compares two common pain medicines given through a patient-controlled pump after lung surgery done with small incisions. The goal is to see which one works better and has fewer side effects.
Zabrze, Silesian VoivodeshipAges 18–75 - NCT07219888Enrolling by invitationPhase 4
Comparing suzetrigine and oxycodone for knee replacement pain
This study compares a new pain medicine called suzetrigine with a commonly used opioid, oxycodone, for pain after a knee replacement. The goal is to see which works better and has fewer side effects.
Louisville, KentuckyAges 21–89 - NCT07001709RecruitingPhase 4
How abiraterone affects oxycodone in prostate cancer
This study looks at how a common prostate cancer drug (abiraterone) affects how the body processes a painkiller (oxycodone). Men with prostate cancer who take abiraterone will be compared with those who do not, to see if the painkiller works differently.
Deventer, OverijsselAges 18 years+ - NCT06186141RecruitingPhase 4
Comparing morphine and oxycodone for kids' pain after surgery
This study compares two common pain medicines—morphine and oxycodone—given through a PCA pump after surgery in children. The goal is to see which one causes less nausea and vomiting, so your child can recover more comfortably.
Melbourne, VictoriaAges 6–18 - NCT05846451RecruitingEarly Phase 1
Study of how kratom and oxycodone interact in healthy adults
This early study tests how kratom can change the body’s handling of oxycodone (a prescription opioid) and how safe and measurable the effects are. It may help researchers understand drug interactions, especially for people who have used kratom and opioids before.
Spokane, WashingtonAges 21–45 - NCT03823534RecruitingPhase 3
Study pain control after preventive femur bone surgery
This Phase 3 study tests a pain medicine plan used after preventive surgery to place a metal rod inside the thigh bone (femur) before a fracture happens. The goal is to find an approach that controls post-surgery pain while being safe for the right patients.
St Louis, MissouriAges 18 years+ - NCT03685188Enrolling by invitationPhase 4
Oxycodone and sufentanil pain medicine for hip surgery
This trial tests whether using oxycodone and sufentanil helps control pain during one-sided hip surgery. It’s meant to see how well these pain medicines work and whether they are safe for patients in this setting.
Chengdu, SichuanAges 18 years+ - NCT06338865Recruiting
Lower pressure vs. standard pressure for laparoscopic gynecologic surgery
This trial compares using lower gas pressure during minimally invasive gynecologic surgery to the standard pressure. The goal is to see if lower pressure reduces pain and speeds recovery after surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT07824258RecruitingPhase 1
Pain relief study after vasectomy
This study tests whether a pain-relief method helps reduce discomfort after a vasectomy. It may help you recover more comfortably.
New York, New YorkAges 18–65 - NCT07773155RecruitingPhase 4
Pain control after hand or wrist surgery: nerve block with or without ketorolac
This study tests two different pain relief methods after hand or wrist surgery: a nerve block alone versus a nerve block plus an anti-inflammatory medication called ketorolac. The goal is to see which approach provides better pain control with fewer side effects.
Chicago, IllinoisAges 18 years+ - NCT07750639Enrolling by invitationPhase 4
Reducing painkiller use after hand surgery
This study tests a new approach to prescribing fewer opioid pain pills after hand, wrist, or elbow surgery. It aims to help reduce the risk of opioid misuse while still controlling pain after surgery.
Orlando, FloridaAges 18 years+ - NCT06690307RecruitingPhase 4
Comparing two pain medicines after laparoscopic hysterectomy
This study compares two pain medicines, oxycodone and sufentanil, given through a pump you control after a laparoscopic hysterectomy. The goal is to see which one provides better pain relief with fewer side effects.
Nantong, JiangsuAges 18–65 - NCT07348627RecruitingPhase 3
Opioid-free hip replacement study
This trial tests if using fewer opioids after hip replacement surgery can still control pain well. It uses a specific type of hip replacement called anterior total hip arthroplasty and aims to help patients recover with less reliance on strong pain medicines.
Atlanta, GeorgiaAges 18 years+ - NCT07218549RecruitingPhase 1
Study of psychoactive substances in people with past opioid use
This trial tests how safe certain psychoactive substances are and what effects they have in people who have used opioids in the past but are not currently dependent on them. It aims to gather information that could help future treatment options.
Houston, TexasAges 18–55 - NCT06878014RecruitingPhase 4
Morphine for pain relief after hip replacement surgery
This trial tests different doses of morphine given during spinal anesthesia to find the safest and most effective way to control pain after hip replacement surgery. If you are having a total hip replacement, you may be able to join.
Sosnowiec, Silesian VoivodeshipAges 18–75 - NCT06757140RecruitingPhase 1/Phase 2
Opioid and sedative-like drug interaction study
This study explores how opioids and sedative-like drugs interact in the body. It aims to understand their combined effects, which could help improve safety for people who use these drugs.
Lexington, KentuckyAges 18–55 - NCT06500793RecruitingPhase 1
Study of oxycodone with nafamostat in healthy adults
This trial tests how a new combination of oxycodone and nafamostat works in the body. It is for healthy volunteers aged 18 to 55 to help understand the drug's safety and how it is processed.
Miami, FloridaAges 18–55
What Oxycodone is being studied for
Conditions with recruiting Oxycodone studies.
Common questions
- Are there clinical trials studying Oxycodone?
- Yes. Clin2 currently lists 34 recruiting studies that include Oxycodone, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Oxycodone trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Oxycodone an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Oxycodone or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.