Treatment clinical trials

Vagus nerve stimulation for stroke recovery

This trial tests whether stimulating the vagus nerve can improve arm movement, breathing, and quality of life in people who had a stroke more than 6 months ago. It involves a non-invasive device that gently stimulates a nerve in the neck during therapy sessions.

Bismuth therapy for H. pylori ulcers in children

This trial tests whether adding bismuth to standard treatment works better for children with stomach ulcers caused by H. pylori infection. If your child has been diagnosed with an H. pylori ulcer, this study could help find the best medicine.

Shorter hormone treatment for low volume spread prostate cancer

This study tests whether a shorter course of a newer hormone pill (apalutamide or enzalutamide) works well for men whose prostate cancer has spread to just a few spots and who recently started standard hormone therapy. It may allow you to take medication for less time while still controlling the cancer.

VSV-02 for advanced solid tumors that need new options

This trial tests an experimental virus therapy called VSV-02 for people with advanced solid tumors that have not responded to standard treatments. The treatment is given directly into a tumor, aiming to attack cancer from the inside.

Capsaicin cream for diabetic nerve foot pain

This trial tests a new cream (Capsadyn®) made from chili pepper extract to see if it can reduce nerve pain in the feet caused by diabetes. If it works, it could offer a simple treatment you apply at home.

KSV01 injection for relapsed DLBCL

This study tests a new injection called KSV01 for people with a type of lymphoma (DLBCL) that has returned or not responded to previous treatments. The goal is to see if it can help shrink tumors or stop the disease from getting worse.

Combination therapy for first-line mantle cell lymphoma

This trial tests a combination of three drugs—obinutuzumab, zanubrutinib, and lenalidomide—as a first treatment for mantle cell lymphoma. The goal is to see if this approach is safe and effective for patients who have not had prior therapy.

Exercises at home for muscle and bone conditions

This study looks at how well people follow a home exercise program for muscle or bone problems. It aims to understand what helps or makes it hard to stick with the exercises.

Blood test and leaflet to guide antibiotic use for respiratory infections

This trial tests if a quick blood test (C-reactive protein, CRP) and a patient leaflet can help doctors prescribe antibiotics only when needed for adults with respiratory tract infections. It aims to reduce unnecessary antibiotic use.

Deep breathing and core exercises for ankylosing spondylitis

This trial tests whether combining deep breathing with core stability exercises helps people with ankylosing spondylitis. It may improve symptoms and quality of life.

Supervision in substance use treatment programs

This trial studies how supervision works in substance use treatment programs. It looks at the roles of supervisors and counselors to help improve treatment for people with substance use disorders.

Saliva protein levels in gum disease severity and smoking

This study looks at a protein called Mitofusin-1 in your saliva to see if its levels are linked to how serious gum disease is, whether you smoke, and how you respond to treatment. Samples will be taken once before any treatment begins.

Recovery of albumin after major liver and pancreas surgery

This trial tracks how quickly your albumin (a protein in your blood) returns to normal after major surgery on your liver, pancreas, or bile ducts, to see if that predicts your recovery. It may help doctors understand how you are healing.

Albumin for large artery stroke after clot removal

This trial tests whether giving albumin, a protein naturally found in blood, can improve recovery after a large artery stroke when given along with a procedure to remove the clot. It's for people aged 18-80 who have a stroke from a blockage in the front part of the brain and can get treatment within 24 hours.

A new plate for fixing broken jawbones

This trial tests a special plate to fix certain types of broken jawbones. It may help patients who have a recent, clean break that needs surgery.

LILRA6 car-t therapy for resistant or relapsed aml

This early-phase trial tests a new cell therapy (CAR-T) that targets a protein called LILRA6 on leukemia cells. It's designed for people whose acute myeloid leukemia (AML) has come back or hasn't responded to standard treatments.

Ivonescimab with or without ligufalimab vs pembrolizumab for head and neck cancer

This trial tests a new immunotherapy combination (ivonescimab alone or with ligufalimab) against the standard immunotherapy pembrolizumab (Keytruda) for people with head and neck cancer that has come back or spread. It may be an option if you have not had any prior immunotherapy and your tumor is PD-L1 positive.

I-arch system for early orthodontic treatment

This study tests a new orthodontic tool, the I-arch system, for straightening the lower front teeth when they are moderately crowded. It aims to see how well the I-arch works during the first stage of braces treatment.

Chemo-immunotherapy before surgery for stage III lung cancer

This trial tests combining chemotherapy with immunotherapy before surgery for people with stage III non-small cell lung cancer that has a PD-L1 level of 1% or higher. The goal is to see if this approach can improve outcomes.

Stem cells plus bypass surgery for chronic heart failure

This trial tests whether injecting stem cells from umbilical cord tissue into the heart muscle during bypass surgery can improve heart function in people with chronic heart failure. It is for patients who are already scheduled for bypass surgery and have a weakened heart pump (LVEF between 21% and 40%).

Heart health study for Ugandan teens and families

This study looks at whether a family-based program can improve heart health for adolescents in Uganda. You and your family would work together on healthy habits over the next year.

Adalimumab after surgery for esophageal cancer

This trial tests whether adding adalimumab (a medicine that helps the immune system) after surgery can prevent esophageal cancer from coming back. It's for people who have already had their cancer completely removed by surgery.

Oral deucrictibant for preventing and treating angioedema attacks in AAE-C1INH

This trial tests two forms of an oral medication to prevent and treat sudden swelling attacks in people with a rare condition called acquired angioedema due to C1 inhibitor deficiency. It aims to see if the drug can reduce attack frequency and manage acute episodes.

Tuvonralimab and Iparomlimab Based Regimens for the Neoadjuvant Treatment of Biliary Tract Cancer