PET scan study of inflammation and cholesterol-lowering treatment
Treatments studied
Part of Brain & nervous system, Genetic & congenital, Heart & circulation, Hormones & metabolism clinical trials.
This study uses PET/CT and related scans to measure inflammation in artery plaque and how cholesterol-lowering treatment changes it. It may help researchers understand which treatments reduce artery inflammation for people with heart or blood-vessel disease and high LDL (“bad”) cholesterol.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be older than 18 and able to sign consent
- You must be able to lie flat during the scans
- You likely have high cholesterol (primary high cholesterol or mixed cholesterol problems)
- You have a history of heart or blood-vessel disease (like heart attack, stroke, or blocked leg arteries) and LDL stays high despite taking the most tolerated statin
- You must have plaque in the carotid artery (neck artery) that measures at least 15 mm on ultrasound
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a special type of PET/MRI scan can help doctors see inflammation in the carotid artery after a stroke or mini-stroke. By using a radioactive tracer, the scan may identify which patients have dangerous plaque buildup that could lead to another stroke.
This study tests two newer cholesterol-lowering medications (inclisiran and alirocumab) together in people who've had heart problems or strokes and cannot tolerate standard cholesterol drugs. The goal is to see if this combination safely lowers cholesterol further and reduces future cardiovascular events.
This trial uses special PET/MR scans to look at fatty buildup in your neck arteries to see which ones might be dangerous. It could help doctors better understand your stroke risk and choose the right treatment.
This Phase 1 study tests whether a special PET scan can detect a specific inflammation signal (CCR2) in atherosclerosis—fatty plaque buildup in blood vessels. It may help future doctors better see which plaques are more inflamed and potentially more dangerous.
This study tests a new medicine called inclisiran (a small interfering RNA) to see if it can shrink or stabilize fatty plaques in neck arteries. You may qualify if you have carotid plaques and high LDL cholesterol despite statin use or if you haven't taken statins.
This trial studies plaque activity in leg arteries using a new imaging method to understand artery disease better. It may help people with peripheral artery disease get more targeted treatment.
Hear when a new Hypercholesterolemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.