Landiolol to prevent death in ventilated septic shock patients
Treatments studied
Part of Heart & circulation, Infections clinical trials.
This trial tests whether landiolol (a short-acting heart-rate–lowering medicine) can reduce deaths compared with standard care in people in septic shock who have a fast heart rate and strong heart pumping. It is meant for a very specific type of critically ill patient while they are on a breathing machine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 years or older
- Be in septic shock with ongoing low blood pressure needing medicines, plus lactate above 2 mmol/L
- Have already received at least 30 mL per kg of fluids, but not improved with fluids
- Have strong heart pumping on ultrasound (left ejection fraction above 65%) and a fast heart rate over 100
- Be on an invasive breathing machine with sedation and pain control
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 3 trial tests whether landiolol (a short-acting heart-rate–lowering medicine) can improve blood circulation in adults with septic shock whose heart rate is too fast. Doctors will also check that the medication is safe in this critical-care setting.
This trial tests whether a heart-rate–controlling medication can better manage a new fast heart rhythm that happens during sepsis shock. It may help reduce heart strain and improve safety compared with standard care.
This trial tests a short-acting medicine called landiolol to see if it can prevent dangerously fast heart rates during and after major surgery. It is for people who have heart risks and are having a planned non-cardiac surgery.
This study tests a heart-slowing medicine called esmolol (a beta-blocker) in people with septic shock and a fast heart rate. It uses ultrasound to see if the medicine is safe and helpful.
This trial tests a special fluid management strategy for people in septic shock—a serious infection that causes very low blood pressure. It aims to improve blood flow to organs and help you recover.
This study tests a medication called esmolol to see if it helps blood flow in tiny blood vessels under the tongue for people with septic shock. If you have a fast heart rate despite treatment, this trial may help your doctors better manage your condition.
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