Oral acetazolamide for worsening heart failure
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests whether taking acetazolamide by mouth can help prevent or improve worsening (decompensation) of heart failure after you needed IV water pills (diuretics). It’s mainly for adults with a recent heart-failure flare and specific heart/lab signs, while carefully excluding certain low blood pressure, kidney issues, and electrolyte or acid–base problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 or older and can sign informed consent.
- You have worsening heart failure that needed IV diuretics during this hospital stay.
- Your left-sided heart pumping may be any level, but you also have signs of heart structure changes or filling problems, and/or elevated BNP/NT-proBNP blood tests.
- You have NOT taken acetazolamide for about the last month before being admitted.
- You must not have very low blood pressure (systolic under 90 mmHg) and must not be pregnant or breastfeeding.
- You must not have certain blood/organ problems (low potassium, low sodium, metabolic acidosis, severe anemia, severe kidney failure/ dialysis/ultrafiltration, or acute kidney failure).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This study tests whether adding acetazolamide (a different type of water pill) to your current treatment helps remove extra fluid from your body more effectively when you are in the hospital for heart failure.
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This trial tests different water pill (diuretic) strategies for people hospitalized with acute heart failure and too much fluid. It is designed for patients who may not respond well to standard water pills, to find a more effective way to relieve symptoms.
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This trial compares two different water pills (acetazolamide and metolazone) added to standard treatment to help remove excess fluid in people hospitalized with acute heart failure. The goal is to find which works better to ease symptoms and improve recovery.
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