Oral acetazolamide for worsening heart failure
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests whether taking acetazolamide by mouth can help prevent or improve worsening (decompensation) of heart failure after you needed IV water pills (diuretics). It’s mainly for adults with a recent heart-failure flare and specific heart/lab signs, while carefully excluding certain low blood pressure, kidney issues, and electrolyte or acid–base problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 or older and can sign informed consent.
- You have worsening heart failure that needed IV diuretics during this hospital stay.
- Your left-sided heart pumping may be any level, but you also have signs of heart structure changes or filling problems, and/or elevated BNP/NT-proBNP blood tests.
- You have NOT taken acetazolamide for about the last month before being admitted.
- You must not have very low blood pressure (systolic under 90 mmHg) and must not be pregnant or breastfeeding.
- You must not have certain blood/organ problems (low potassium, low sodium, metabolic acidosis, severe anemia, severe kidney failure/ dialysis/ultrafiltration, or acute kidney failure).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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