Blood pressure and cholesterol treatment for Alzheimer's prevention
Treatments studied
Part of Heart & circulation, Hormones & metabolism clinical trials.
This study tests whether actively lowering blood pressure and cholesterol can slow down or prevent memory decline in people who carry a genetic risk for Alzheimer's disease. It aims to see if these treatments can help keep your brain healthy as you age.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 50 and 75 years old.
- You must carry a specific gene variant called APOE ε4 (a genetic risk factor for Alzheimer's).
- Your LDL ('bad') cholesterol must be between 100 and 250 mg/dL, and your systolic blood pressure (the top number) must be between 130 and 180 mm Hg.
- You must not have dementia or be taking any medications for dementia.
- You must be able to speak English fluently.
- If you are a woman, you must be post-menopausal (no periods for at least a year).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether setting a lower blood pressure goal can help prevent future memory and thinking problems in older adults. It compares a more intensive blood pressure plan with usual care to see if it better protects the brain over time.
This study tests whether eating more polyphenols (natural compounds in plants) can protect brain health in people at higher risk for Alzheimer's disease, especially if they currently eat a typical Western diet. Participants will be followed over time to see if changes in diet affect thinking and memory.
This study tests two approaches together: a computer-based brain training program and a stronger cholesterol-lowering medicine, to see if they can help improve memory and thinking in people with narrowed brain arteries. You would be randomly assigned to different combinations of the two, and the doctors will monitor your progress.
This study tests whether better blood pressure control can slow changes seen on brain scans in older people. It focuses on people with high blood pressure and “wear-and-tear” type brain lesions on MRI.
This study tests a new medication, CORT108297, that may help protect the brain from the harmful effects of stress in people at risk for Alzheimer's disease. It is looking for adults age 55 and older who either have mild memory problems or are healthy but have a family history, APOE4 gene, or memory concerns.
This trial tests whether acupuncture can help people with Alzheimer's disease. Researchers will compare results in people who carry the APOE e4 gene and those who don't, to see if the treatment works differently.
Hear when a new High blood pressure trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.