Clinical trials
Acute Pain clinical trials
Below are recruiting acute pain clinical trials, each written for real people, not researchers. We’re tracking 202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06864884RecruitingEarly Phase 1
Study of ARC-001 for wisdom teeth removal
This trial tests a new medicine called ARC-001 in people who are scheduled to have their wisdom teeth taken out. The goal is to see if it's safe and how it affects pain and healing.
Salt Lake City, UtahAges 18–55 - NCT06863636RecruitingPhase 3
Combination painkiller vs celecoxib for osteoarthritis flare-ups
This study tests whether a combination of two pain relievers (celecoxib and acetaminophen) works better than celecoxib alone for sudden, severe osteoarthritis pain in the knee or hip.
Mexico CityAges 40 years+ - NCT06861582Recruiting
Faster troponin test for chest pain in the ER
This study tests a faster way to measure a heart-muscle protein (troponin) in the emergency room, to see if it can help doctors decide sooner whether your chest pain is from a heart attack. If you are having chest pain that started a few hours ago, you may be able to join.
São PauloAges 18 years+ - NCT07008391Recruiting
High-sensitivity troponin test in ambulance care
This trial tests whether using a high-sensitivity troponin I test in the ambulance, along with standard care, can help emergency medical services better identify heart attacks. This might lead to faster treatment for patients with chest pain or suspected heart attack.
Stockholm, ÅrstaAges 18 years+ - NCT05141591Recruiting
Anxiety before ENT surgery and opioid use after surgery
This trial looks at whether people’s anxiety before ear, nose, and throat (ENT) surgery affects how much pain medicine (opioids) they need after surgery. It may help doctors better plan pain control based on anxiety level and possibly gender-related patterns.
Vienna, State of ViennaAges 18 years+ - NCT06684665Enrolling by invitation
How emotions and social factors affect low back pain
This study looks at how social, psychological, and emotional factors might cause problems with movement and daily life in people with back pain. It could help doctors better understand and treat your pain.
Wenzhou, ZhejiangAges 18–75 - NCT07327138Recruiting
Laughter and yoga for kids with leukemia after chemo
This study tests if fun yoga and laughter exercises at home can help children aged 2-10 with a type of leukemia feel less pain after chemotherapy. It's designed to be gentle and safe, with a parent or guardian joining in.
SidonAges 2–10 - NCT05854914Recruiting
Smartphone hypnosis to reduce pain after emergency appendix surgery
This study tests whether guided hypnosis on a smartphone can lower pain after emergency surgery for a complicated appendicitis. If you qualify, you’ll use the app during your recovery and also answer quick questions about your pain and anxiety.
NiceAges 18 years+ - NCT02355457Recruiting
Blood marker study in new heart attack symptoms
This study looks at blood “biomarkers” (signals in blood tests) in people who arrive with symptoms that could be a heart attack. It may help doctors spot and manage acute heart problems sooner and more accurately.
HamburgAges 18 years+ - NCT06158620RecruitingPhase 1/Phase 2
Nasal spray for pain after ureter stent placement
This trial tests whether a nasal spray form of the painkiller ketorolac can safely reduce pain from a ureteral stent after stone surgery. If you are having a ureteroscopy with stent placement, this might help you manage discomfort without stronger medications.
Dallas, TexasAges 18 years+ - NCT07250399Recruiting
Pain after root canal treatment with different tools
This trial compares two different ways of cleaning a tooth's root canal to see which causes less pain during and after treatment. It is for people with severe tooth pain in an upper premolar.
CairoAges 20–50 - NCT07361796Recruiting
Venlafaxine to prevent nerve pain after shingles
This trial tests whether the drug venlafaxine, usually used for depression, can help prevent long-term nerve pain (postherpetic neuralgia) after a shingles infection. If you are currently experiencing shingles pain, joining this study might reduce your chances of developing chronic pain later.
BeijingAges 18 years+ - NCT07079865Recruiting
Nerve stimulation for pain after spine fracture
This trial tests a 60-day nerve stimulation treatment to reduce pain and improve mobility after a recent spine fracture caused by osteoporosis. It may help patients who still have significant pain despite over-the-counter pain relievers.
Avenel, New JerseyAges 18 years+ - NCT05328401Recruiting
Laser acupuncture for shoulder pain after stroke
This trial tests whether laser acupuncture can reduce shoulder pain in people recovering from a stroke. It compares outcomes while making sure participants are not using certain pain medicines or shoulder injections that could affect results.
Keelung, TaiwanAges 20 years+ - NCT06963658Recruiting
Isometric Exercise and Pain Sensitivity in Chronic Low Back Pain
This study tests whether a simple, still (isometric) exercise can reduce how sensitive you are to pain. It is for adults with long-term low back pain who can safely do physical therapy exercises.
Bisha, 'Asir RegionAges 18 years+ - NCT06859723RecruitingPhase 1
Effects of high potency cannabis on daily users
This study tests how high potency cannabis affects mood, thinking, and pain sensitivity in people who smoke cannabis almost every day. It will help researchers understand both immediate and long-lasting effects.
Los Angeles, CaliforniaAges 21–55 - NCT06886906Recruiting
Movement and Pain in Older Adults
This study explores how movement and physical activity relate to pain in older adults with muscle or joint pain. It could help you understand your pain patterns and find better ways to manage them.
Indianapolis, IndianaAges 55–85 - NCT04709900Recruiting
Tests for stable chest pain using heart scans and pressure measurements
This trial studies how well different heart tests (imaging the blood flow and measuring blood pressure in the heart) work for people with stable chest pain. It may help guide safer, more accurate evaluation when you are not having a heart attack.
CopenhagenAges Any age - NCT05325580RecruitingPhase 3
IV magnesium vs placebo for sudden non-injury headaches
This trial tests whether giving magnesium sulfate through a vein in the emergency room can reduce sudden (non-injury) acute headaches compared with a placebo. It may help people whose headache comes on suddenly and is not caused by an injury.
MonastirAges 18–85 - NCT07244861Enrolling by invitation
TENS for neck muscle stiffness and pain
This study tests whether a gentle electrical stimulation device (TENS) applied to the neck can reduce muscle stiffness and pain in people with ongoing neck pain. If you have had neck pain for at least 6 weeks and are willing to avoid certain medications the day before, you may be able to join.
ErzurumAges 18–50 - NCT07203040Enrolling by invitation
Ultrasound therapy for neck pain relief and muscle stiffness
This trial tests if a gentle ultrasound treatment can reduce neck pain and stiffness. It may be an option if you have ongoing neck pain and haven't had neck procedures recently.
ErzurumAges 18–50 - NCT06994442RecruitingPhase 3
Best pain relief for children on a breathing tube
This study tests adding extra pain medicines (acetaminophen or an NSAID) to usual opioid pain treatment for children on a breathing machine. The goal is to find the safest and most effective way to manage pain.
Little Rock, ArkansasAges 2 months–17 years - NCT07620119Recruiting
AI-assisted heart attack diagnosis in patients with LBBB
This study tests whether artificial intelligence can help doctors more accurately diagnose heart attacks in patients who have a specific heart rhythm pattern called Left Bundle Branch Block (LBBB). The goal is to improve emergency care by reducing delays in identifying who needs urgent treatment.
Konya, KaratayAges 18 years+ - NCT07579312Recruiting
Blood Test for Diagnosing Belly Infections in Kids and Adults
This study tests whether a simple blood test measuring RNA levels can help doctors quickly identify intra-abdominal infections (infections inside the belly) in patients with abdominal pain. If successful, it could help doctors decide faster whether imaging or surgery is needed.
Washington D.C., District of ColumbiaAges 7 years+
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Common questions
- Are there clinical trials for acute pain?
- Yes. Clin2 currently lists 202 recruiting acute pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.