Clinical trials
Acute Pain clinical trials
Below are recruiting acute pain clinical trials, each written for real people, not researchers. We’re tracking 211 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06196307Recruiting
Early warning system for sudden chest pain
This trial is for people who come to the emergency room with new or worsening chest pain not caused by an injury. It aims to build an early warning system to better classify and treat chest pain.
Beijing, ChaoyangAges 18 years+ - NCT05721027RecruitingPhase 4
Ibuprofen alone or with a steroid for new sciatica pain
This trial compares ibuprofen alone versus ibuprofen plus dexamethasone (a steroid) for short-term relief of acute nerve-related low back pain that shoots into the buttock or leg. It aims to see which approach reduces pain and improves function after an emergency visit.
The Bronx, New YorkAges 18–70 - NCT05345015Recruiting
Radio waves for muscle or low back pain and function
This trial tests whether a high-frequency radio-wave treatment can reduce pain and improve movement in adults with a muscle strain (hamstring) or acute or chronic low back pain. It may help you feel less pain and function better, depending on your specific injury and medical details.
KavalaAges 18–65 - NCT07588490Recruiting
TENS for sudden severe lower back pain in the emergency room
This trial tests a pain-relief device called TENS (a small machine that sends mild electrical pulses through your skin) for people with sudden, severe lower back pain in the emergency department. Researchers want to see if TENS can help reduce your pain quickly without extra medications.
BrusselsAges 18 years+ - NCT07375914Recruiting
New approach for managing acute low back pain in the ER
This trial tests a comprehensive program that looks at your physical, mental, and social needs to treat sudden low back pain in the emergency room. It may help you get better care and avoid long-term pain.
ParisAges 18–55 - NCT05141591Recruiting
Anxiety before ENT surgery and opioid use after surgery
This trial looks at whether people’s anxiety before ear, nose, and throat (ENT) surgery affects how much pain medicine (opioids) they need after surgery. It may help doctors better plan pain control based on anxiety level and possibly gender-related patterns.
Vienna, State of ViennaAges 18 years+ - NCT05534945Recruiting
Finds the best epidural pain dose after laparotomy surgery
This study tests different doses of epidural pain medicine to see what works best for pain control after laparotomy surgery. You might benefit from carefully tailored pain relief, but you must meet safety and communication requirements.
Montreal, QuebecAges 18–85 - NCT07575555Recruiting
Lipedema's role in knee arthritis in women
This study compares women with knee arthritis who do or don't have lipedema (a condition causing painful fat buildup, usually in the legs) to understand how lipedema affects knee joint health. Results may help doctors better treat knee arthritis in women with lipedema.
Izmir, İzmirAges 30–65 - NCT06861582Recruiting
Faster troponin test for chest pain in the ER
This study tests a faster way to measure a heart-muscle protein (troponin) in the emergency room, to see if it can help doctors decide sooner whether your chest pain is from a heart attack. If you are having chest pain that started a few hours ago, you may be able to join.
São PauloAges 18 years+ - NCT06863636RecruitingPhase 3
Combination painkiller vs celecoxib for osteoarthritis flare-ups
This study tests whether a combination of two pain relievers (celecoxib and acetaminophen) works better than celecoxib alone for sudden, severe osteoarthritis pain in the knee or hip.
Mexico CityAges 40 years+ - NCT06864884RecruitingEarly Phase 1
Study of ARC-001 for wisdom teeth removal
This trial tests a new medicine called ARC-001 in people who are scheduled to have their wisdom teeth taken out. The goal is to see if it's safe and how it affects pain and healing.
Salt Lake City, UtahAges 18–55 - NCT07008391Recruiting
High-sensitivity troponin test in ambulance care
This trial tests whether using a high-sensitivity troponin I test in the ambulance, along with standard care, can help emergency medical services better identify heart attacks. This might lead to faster treatment for patients with chest pain or suspected heart attack.
Stockholm, ÅrstaAges 18 years+ - NCT06684665Enrolling by invitation
How emotions and social factors affect low back pain
This study looks at how social, psychological, and emotional factors might cause problems with movement and daily life in people with back pain. It could help doctors better understand and treat your pain.
Wenzhou, ZhejiangAges 18–75 - NCT05854914Recruiting
Smartphone hypnosis to reduce pain after emergency appendix surgery
This study tests whether guided hypnosis on a smartphone can lower pain after emergency surgery for a complicated appendicitis. If you qualify, you’ll use the app during your recovery and also answer quick questions about your pain and anxiety.
NiceAges 18 years+ - NCT07327138Recruiting
Laughter and yoga for kids with leukemia after chemo
This study tests if fun yoga and laughter exercises at home can help children aged 2-10 with a type of leukemia feel less pain after chemotherapy. It's designed to be gentle and safe, with a parent or guardian joining in.
SidonAges 2–10 - NCT02355457Recruiting
Blood marker study in new heart attack symptoms
This study looks at blood “biomarkers” (signals in blood tests) in people who arrive with symptoms that could be a heart attack. It may help doctors spot and manage acute heart problems sooner and more accurately.
HamburgAges 18 years+ - NCT06158620RecruitingPhase 1/Phase 2
Nasal spray for pain after ureter stent placement
This trial tests whether a nasal spray form of the painkiller ketorolac can safely reduce pain from a ureteral stent after stone surgery. If you are having a ureteroscopy with stent placement, this might help you manage discomfort without stronger medications.
Dallas, TexasAges 18 years+ - NCT07250399Recruiting
Pain after root canal treatment with different tools
This trial compares two different ways of cleaning a tooth's root canal to see which causes less pain during and after treatment. It is for people with severe tooth pain in an upper premolar.
CairoAges 20–50 - NCT07079865Recruiting
Nerve stimulation for pain after spine fracture
This trial tests a 60-day nerve stimulation treatment to reduce pain and improve mobility after a recent spine fracture caused by osteoporosis. It may help patients who still have significant pain despite over-the-counter pain relievers.
Avenel, New JerseyAges 18 years+ - NCT07361796Recruiting
Preventing nerve pain after shingles with venlafaxine
This trial tests if the antidepressant venlafaxine can prevent long-term nerve pain (postherpetic neuralgia) in people who currently have shingles. If you have moderate to severe shingles pain, this study may help find a way to stop the pain from becoming chronic.
BeijingAges 18 years+ - NCT05328401Recruiting
Laser acupuncture for shoulder pain after stroke
This trial tests whether laser acupuncture can reduce shoulder pain in people recovering from a stroke. It compares outcomes while making sure participants are not using certain pain medicines or shoulder injections that could affect results.
Keelung, TaiwanAges 20 years+ - NCT06526572Recruiting
Pain measurement with brain waves in tooth infection
This trial tests a new way to measure pain from a tooth infection using brain wave recordings (EEG). It may help people whose numbing injection doesn't work well.
Cleveland, OhioAges 18–50 - NCT06963658Recruiting
Isometric Exercise and Pain Sensitivity in Chronic Low Back Pain
This study tests whether a simple, still (isometric) exercise can reduce how sensitive you are to pain. It is for adults with long-term low back pain who can safely do physical therapy exercises.
Bisha, 'Asir RegionAges 18 years+ - NCT06859723RecruitingPhase 1
Effects of high potency cannabis on daily users
This study tests how high potency cannabis affects mood, thinking, and pain sensitivity in people who smoke cannabis almost every day. It will help researchers understand both immediate and long-lasting effects.
Los Angeles, CaliforniaAges 21–55
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Common questions
- Are there clinical trials for acute pain?
- Yes. Clin2 currently lists 211 recruiting acute pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.