Clinical trials
Advanced or Metastatic Non-small Cell Lung Cancer clinical trials
Below are recruiting advanced or metastatic non-small cell lung cancer clinical trials, each written for real people, not researchers. We’re tracking 5,550 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07222397Recruiting
Laser treatment for deep wrinkles around the mouth
This study tests a special laser to treat deep lines and wrinkles around the mouth. It may help if you are between 50 and 80 years old and have fair to light brown skin.
Houston, TexasAges 50–80 - NCT06860477RecruitingPhase 2
Freezing therapy plus targeted drugs vs. chemotherapy for advanced bile duct cancer
This trial tests whether a combination of cryoablation (freezing tumors) and two drugs (lenvatinib and tislelizumab) works better than a standard chemotherapy regimen (FOLFOX) for people with advanced intrahepatic cholangiocarcinoma (a type of bile duct cancer in the liver) that has not responded to or has stopped responding to one prior therapy.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06914674RecruitingPhase 2
Tamoxifen for advanced pancreatic SPTP
This trial tests whether tamoxifen, a hormone therapy drug, can shrink or slow down advanced solid pseudopapillary tumors of the pancreas (SPTP) that have estrogen and progesterone receptors. It may be an option for people whose tumors cannot be removed by surgery or have come back after other treatments.
ShanghaiAges 14–80 - NCT07216794RecruitingPhase 2
Alendronate trial to reduce hidden HIV
This study tests if alendronate, a bone-strengthening medicine, can shrink the reservoir of HIV that stays in your body even when on treatment. You must have well-controlled HIV on antiretroviral therapy for at least one year but no more than ten years, and meet specific health requirements.
San Francisco, CaliforniaAges 18–65 - NCT07213609RecruitingPhase 1/Phase 2
Study of GSK5460025 for advanced solid tumors
This trial tests a new drug, GSK5460025, alone or with other cancer treatments, for people with advanced solid tumors that have spread or cannot be removed by surgery. It may help those whose cancer has a specific genetic feature (dMMR or MSI-H) or who have not responded to standard treatments.
Aurora, ColoradoAges 18 years+ - NCT07217821Recruiting
Music and imagery for chronic pain
This study tests a step-by-step approach using music and guided imagery to help people with long-term muscle or joint pain. It's done from home using a device, so you don't need to travel.
Indianapolis, IndianaAges 18 years+ - NCT07218666RecruitingPhase 2
Zanzalintinib for aggressive prostate cancer
This trial tests a new drug, zanzalintinib, in men with a fast-growing type of prostate cancer that has spread and stopped responding to standard hormone therapies. It aims to see if the drug can help shrink tumors or slow the disease.
Milwaukee, WisconsinAges 18 years+ - NCT07215182RecruitingPhase 2
New PET scan method for advanced melanoma
This trial tests a new type of PET scan that may find cancer more clearly and quickly than current scans. It's for people with advanced melanoma that has spread and cannot be removed by surgery.
Herlev, Capital RegionAges 18 years+ - NCT06710379RecruitingPhase 1
Testing ADRX-0405 for advanced solid tumors
This trial tests a new drug called ADRX-0405 in people with advanced solid tumors like prostate, stomach, or lung cancer. The goal is to see how safe it is and if it shrinks tumors.
Duarte, CaliforniaAges 18 years+ - NCT04705467Recruiting
3D scanning of needles during gynecologic radiation treatment
This study uses 3D imaging to help guide needle-based radiation treatment for certain gynecologic cancers. If you are already scheduled to receive this type of brachytherapy, the trial may help make the treatment planning more accurate.
London, OntarioAges 18 years+ - NCT07204340RecruitingPhase 1
TLN-372 for advanced KRAS-mutant solid tumors
This trial tests a new drug called TLN-372 for people with advanced solid tumors that have a KRAS mutation. It aims to see if the drug is safe and effective for these cancers.
Birmingham, AlabamaAges 18 years+ - NCT07209111RecruitingPhase 2
Testing Calderasib for advanced solid tumors with KRAS G12C mutation
This trial tests a new drug, Calderasib (MK-1084), for people with advanced solid tumors that have a specific KRAS G12C mutation and aren't getting better with standard treatments. The goal is to see if the drug can help shrink or control the cancer.
Baltimore, MarylandAges 18 years+ - NCT07207707RecruitingPhase 1
KQB548 for advanced solid tumors with KRAS G12D mutation
This trial tests a new drug called KQB548 for people with certain advanced cancers (pancreatic, colorectal, or lung) that have a specific genetic change called KRAS G12D. It's for those whose cancer has continued to grow despite previous treatments.
La Jolla, CaliforniaAges 18 years+ - NCT07209306Recruiting
Psychological help for migrants in Italy: The ADVANCE trial
This trial tests two WHO-designed psychological programs (called SH+ and DWM) to help migrants in Italy cope with stress, anxiety, and depression. You will be randomly assigned to one of the programs to see if they improve your mental health and well-being.
Verona, ItalyAges 18 years+ - NCT07211373Enrolling by invitation
Suicide prevention study for college students
This study tests a technology-based program to help undergraduate students who have recently had suicidal thoughts or behaviors. It aims to find better ways to support students in distress.
Amherst, MassachusettsAges 18 years+ - NCT06355583RecruitingPhase 2
Gut bacteria transplant before stem cell transplant
This trial tests whether giving a transplant of healthy gut bacteria (fecal microbiota transplant) before a stem cell transplant can improve outcomes for people with certain blood cancers or bone marrow disorders.
Birmingham, EnglandAges 18 years+ - NCT06923345RecruitingPhase 2
Modified long-course radiation and chemo with immunotherapy for rectal cancer
This trial tests a treatment plan involving radiation, chemotherapy, and an immunotherapy drug (a PD-1 inhibitor) for people with a specific type of high-risk rectal cancer. The goal is to see if this combination helps shrink the tumor before surgery.
Guangzhou, GuangdongAges 18–75 - NCT05564091Recruiting
Add a minimally invasive canaloplasty step to cataract surgery
This trial compares standard cataract surgery alone versus cataract surgery plus a procedure to improve fluid drainage in the eye. It is intended for people with mild to moderate open-angle glaucoma, to see if adding this step helps control eye pressure and preserve vision.
Sugar Land, TexasAges 55 years+ - NCT05749432RecruitingPhase 1
Testing a new medicine for advanced solid tumors
This early-phase study (Phase 1) tests Hemay181, a new cancer medicine, in people with advanced solid tumors that have not been controlled by standard treatment. The goal is to see how the medicine works in the body and whether it can shrink or control tumors safely.
Beijing, Beijing MunicipalityAges 18–65 - NCT05786196Recruiting
Testing canaloplasty surgery for mild to moderate glaucoma
This study tests how well a specific glaucoma surgery (canaloplasty) works on its own for people with mild to moderate primary open-angle glaucoma. It may help if drops (eye medicines) do not work well for you or you need fewer eye drops.
DüsseldorfAges 22 years+ - NCT07195916RecruitingPhase 1
Testing a new drug for advanced solid tumors and blood cancers
This trial tests a new drug called INCA036873, which targets CD70 on cancer cells, for people with advanced solid tumors or certain blood cancers that have not responded to prior treatments. The goal is to see if it is safe and effective against these tough-to-treat cancers.
Duarte, CaliforniaAges 18 years+ - NCT07193550RecruitingPhase 2
Testing Zanzalintinib for Advanced Bone Sarcomas
This trial tests a new drug called zanzalintinib for people with advanced or metastatic bone sarcomas that have not responded to standard treatments. It aims to see if the drug can help shrink or slow the growth of these tumors.
Houston, TexasAges 18 years+ - NCT07193654RecruitingPhase 2
Combined stupp therapy and spinal chemo for advanced glioblastoma
This trial tests adding a chemotherapy drug (thiotepa) directly into the spinal fluid for people with a newly diagnosed glioblastoma that has spread to the brain's lining or ventricles. It aims to see if this extra treatment can help control the cancer.
Hangzhou, ZhejiangAges 18–75 - NCT07199764RecruitingPhase 2
Maintenance therapy using combination immunotherapy for pancreatic cancer
This trial tests a combination of immunotherapy drugs (targeting CD40 and other immune cells) as a maintenance treatment for people with advanced pancreatic cancer that has not grown or has shrunk after initial chemotherapy. The goal is to see if this approach can keep the cancer from progressing longer.
Philadelphia, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for advanced or metastatic non-small cell lung cancer?
- Yes. Clin2 currently lists 5,550 recruiting advanced or metastatic non-small cell lung cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic non-small cell lung cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic non-small cell lung cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Metastatic Non-squamous Non Small Cell Lung Cancer
- Advanced Non-squamous Non-small-cell Lung Cancer
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
- Non Small Cell Lung Cancer
- Non-squamous Non-small Cell Lung Cancer
- Locally Advanced Non-Small Cell Lung Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.