Clinical trials
Advanced or Metastatic Non-small Cell Lung Cancer clinical trials
Below are recruiting advanced or metastatic non-small cell lung cancer clinical trials, each written for real people, not researchers. We’re tracking 5,673 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07307456RecruitingPhase 2
Toripalimab and BCG for high-risk bladder cancer
This trial tests a combination of two treatments after bladder tumor surgery: a drug called toripalimab (given through a vein) plus BCG therapy (given into the bladder) for people with high-risk non-muscle-invasive bladder cancer. The goal is to see if this combination can help prevent the cancer from coming back.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07213609RecruitingPhase 1/Phase 2
Study of GSK5460025 for advanced solid tumors
This trial tests a new drug, GSK5460025, alone or with other cancer treatments, for people with advanced solid tumors that have spread or cannot be removed by surgery. It may help those whose cancer has a specific genetic feature (dMMR or MSI-H) or who have not responded to standard treatments.
Aurora, ColoradoAges 18 years+ - NCT07438782RecruitingPhase 1
Study of a new drug for advanced solid tumors
This trial tests a new drug, GSK5533524, alone or with other treatments, for people with advanced solid tumors that have stopped responding to standard therapies. It aims to find out if the drug is safe and shows early signs of working.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05307705RecruitingPhase 1
Testing LOXO-783 for PIK3CA-mutated cancers
This trial tests an experimental drug (LOXO-783) for people with advanced breast cancer or other solid tumors that have a specific change in the PIK3CA gene. The goal is to see if the drug can shrink or slow the growth of the cancer.
Scottsdale, ArizonaAges 18 years+ - NCT06070376Recruiting
Comparing two stents for esophageal cancer swallowing problems
This study compares two types of stents (metal tubes) placed in the esophagus to help people with advanced esophageal cancer swallow more easily. Both stents are designed to keep the esophagus open and improve quality of life.
São Paulo, São PauloAges 18 years+ - NCT07708935Recruiting
Study of young patients with solid tumors in China
This study looks at young people (40 or younger at diagnosis) with solid tumors in China. It aims to collect real-world information about their treatments and outcomes to find patterns that could help improve care.
ShanghaiAges 18–80 - NCT07706985RecruitingPhase 3
Immunotherapy for advanced nasopharyngeal cancer
This trial tests a new combination of chemotherapy and immunotherapy drugs for advanced nasopharyngeal cancer that has not spread to distant parts of the body. The goal is to see if this approach works better than standard treatment.
Guangzhou, GuangdongAges 18–70 - NCT06399991Recruiting
Improving mental health care in Malawi clinics
This study is testing a new way to help clinics in Malawi better support patients with mental health needs. If you are an adult patient at a participating clinic who has recently had symptoms of depression or anxiety, you may be eligible.
ChiradzuluAges 18 years+ - NCT07705438Recruiting
PET scan to predict if immunotherapy works in TNBC
This trial tests a new type of PET scan (Granzyme B-PET) to see if it can predict how well immunotherapy will work for people with triple-negative breast cancer that has spread. If it works, doctors might be able to tell sooner whether treatment is helping.
ShanghaiAges 18 years+ - NCT07602777RecruitingPhase 1/Phase 2
Testing Risvutatug Rezetecan for Advanced Bone and Soft Tissue Sarcomas
This study tests a new cancer drug called risvutatug rezetecan for people with advanced sarcomas (bone or soft tissue cancers) that have stopped responding to prior treatments. The drug works by delivering a cancer-killing agent directly to tumor cells.
Toronto, OntarioAges Any age - NCT03016819RecruitingPhase 3
Test drugs anlotinib and catequentinib for advanced sarcoma
This Phase 3 study tests two anti-cancer medicines (anlotinib and catequentinib) for people with certain advanced soft-tissue sarcomas, including alveolar soft part sarcoma, synovial sarcoma, and leiomyosarcoma. It is designed for tumors that cannot be removed and that have either grown despite treatment or no longer respond to standard options.
Phoenix, ArizonaAges 18 years+ - NCT03067051RecruitingPhase 1/Phase 2
Test of a prostate cancer light-activated treatment device
This study tests the safety and early effectiveness of the SpectraCure P18 system, which uses light-activated medicine to treat prostate cancer that has come back locally after radiation. It may help some people avoid or delay more invasive treatment, while researchers carefully watch side effects.
New York, New YorkAges 18 years+ - NCT03125343Recruiting
Watch-and-wait after rectal cancer treatment for select patients
This study looks at whether some people with rectal cancer can safely avoid immediate surgery after (chemo)radiation, instead closely monitoring their response. It may help some patients reduce treatment burden if the cancer fully responds.
GothenburgAges 18 years+ - NCT03135327Recruiting
Eye scans study to compare brain and eye health
This study uses detailed eye imaging to look for patterns that may go along with conditions like Alzheimer’s disease, memory problems, multiple sclerosis, or eye/vascular issues. It may help researchers better understand how eye findings relate to health and disease.
Miami, FloridaAges 18–99 - NCT03291652Recruiting
Imaging study of high-risk brain plaque in stroke
This study uses MRI and ultrasound to look closely at brain artery plaques that may release clots and cause stroke. It aims to better understand which plaque features signal higher “embolus” risk, which could guide future care.
Hong KongAges 30–85 - NCT03398369Recruiting
Imaging study to guide heart failure device treatment
This study uses advanced heart imaging to better understand heart function in people who may benefit from a cardiac resynchronization therapy (CRT) device. It aims to find ways to improve how doctors choose treatment and tailor care.
Charlottesville, VirginiaAges 20–90 - NCT03398161RecruitingPhase 2
Very low-dose skin radiation for mycosis fungoides spots
This trial tests whether ultra low-dose radiation can control specific skin lesions from mycosis fungoides (a type of lymphoma that affects the skin). It may help shrink or control targeted spots while using a lower radiation amount.
Houston, TexasAges 18 years+ - NCT03561766Recruiting
Pregnancy birth-cohort study for early pregnancy participants
This study follows pregnant people from early pregnancy to help researchers better understand health and outcomes over time. It’s mainly for those who plan to receive care and deliver at Shengjing Hospital in the Shenyang area.
Shenyang, LiaoningAges 18 years+ - NCT03649880RecruitingPhase 2
Testing a special PET scan for brain tumor activity
This trial studies whether a brain PET scan using a medicine called FMISO can help show how active certain brain tumors are. It mainly aims to see if the scan is practical and useful in planning care for people with suspected or known brain tumors.
Portland, OregonAges 18 years+ - NCT03667170RecruitingPhase 2
Study drug for certain colon cancers with MSI-H or dMMR
This Phase 2 trial tests KN035 in people with advanced or spread-out tumors that have specific genetic markers (MSI-H or dMMR). If you qualify, the study team will look at how well the drug works and how it affects side effects in that group.
Beijing, Beijing MunicipalityAges 18 years+ - NCT03785288RecruitingPhase 3
Testing different schedules of vaginal radiation after hysterectomy
This trial compares different “fractionation” schedules (how often and how many treatments) of vaginal brachytherapy radiation given after surgery for certain early-stage endometrial cancer. It may help find a plan that works well while aiming to control side effects.
Baltimore, MarylandAges 18 years+ - NCT03800693RecruitingPhase 2
Shorter vs longer oxaliplatin infusions for gut cancer
This Phase 2 study compares giving oxaliplatin by IV for 2 hours versus 6 hours, along with the standard FOLFOX6 chemotherapy. It aims to see if the shorter infusion works as well and is manageable for people with gastrointestinal cancers.
Atlanta, GeorgiaAges 18 years+ - NCT03855800Recruiting
Test to detect risky changes in pancreatic cysts
This study looks for molecular (lab) signals that may show advanced or higher-risk changes in certain pancreatic cysts. It may help doctors better sort which cysts are more concerning and may need closer attention.
Rochester, MinnesotaAges 18–120 - NCT03899428RecruitingPhase 2
Immune therapy versus targeted therapy for advanced liver cancer
This trial compares an immune “checkpoint” medicine to a targeted cancer medicine in people with advanced liver cancer who have hepatitis B in the blood. It aims to lower hepatitis B surface antigen (HBsAg) levels and see which approach works better and is safest.
Hong Kong, Hong Kong SARAges 18 years+
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Common questions
- Are there clinical trials for advanced or metastatic non-small cell lung cancer?
- Yes. Clin2 currently lists 5,673 recruiting advanced or metastatic non-small cell lung cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic non-small cell lung cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic non-small cell lung cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Metastatic Non-squamous Non Small Cell Lung Cancer
- Advanced Non-squamous Non-small-cell Lung Cancer
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
- Non Small Cell Lung Cancer
- Non-squamous Non-small Cell Lung Cancer
- Locally Advanced Non-Small Cell Lung Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.