Clinical trials
Advanced or Metastatic Solid Tumors clinical trials
Below are recruiting advanced or metastatic solid tumors clinical trials, each written for real people, not researchers. We’re tracking 4,769 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03941756Recruiting
Lymph bypass before underarm node surgery to prevent swelling
This study looks at whether adding a lymph “bypass” procedure before underarm lymph node surgery can lower the chance of arm or chest swelling (lymphedema) after cancer treatment. It compares people having lymph node surgery for breast cancer with plans for radiation, and a melanoma comparison group.
Houston, TexasAges 18 years+ - NCT03967834Recruiting
Study of immune features in rare soft tissue sarcoma
This study looks at immune system “fingerprints” using tumor tissue from people with rare soft tissue sarcoma. It may help researchers understand what drives these cancers and guide future treatments.
BesançonAges 18 years+ - NCT03606967RecruitingPhase 2
Individualized vaccine added to standard treatment for metastatic triple-negative breast cancer
This Phase 2 trial tests whether adding a personalized cancer vaccine to durvalumab (an immunotherapy), tremelimumab (another immunotherapy), and chemotherapy can improve outcomes for people with metastatic triple-negative breast cancer. It may help your immune system recognize your specific tumor features.
Orange, CaliforniaAges 18 years+ - NCT07883655Recruiting
Finding biological markers to improve care for spinal muscular atrophy
This study looks for natural substances in the blood that may help doctors better understand and treat spinal muscular atrophy. It involves blood samples and other biological specimens from patients with SMA, including newborns detected through screening.
GenovaAges Any age - NCT07510451Recruiting
Predicting low blood pressure during major aortic surgery
This trial tests a new monitoring tool that predicts drops in blood pressure before they happen during major aortic surgery. It may help doctors keep your blood pressure more stable during the procedure.
PoznanAges 18 years+ - NCT06043713RecruitingPhase 1
T-cell therapy for KRAS G12V solid tumors
This trial tests a personalized T-cell therapy designed to recognize and attack cancer cells with a specific KRAS G12V mutation. It is for people with metastatic solid tumors that have this mutation and a specific immune type (HLA-A*11:01).
Seattle, WashingtonAges 18 years+ - NCT07748208RecruitingPhase 2
Drug combination for advanced breast cancer with type 2 diabetes
This trial combines two or three drugs (inavolisib, fulvestrant, and sometimes palbociclib) to treat hormone receptor positive, HER2 negative advanced breast cancer that has a PIK3CA mutation. The goal is to find out if this combination is safe and effective for people who also have type 2 diabetes.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06345729RecruitingPhase 3
Combination drug therapy for advanced lung cancer
This trial tests a new pill (calderasib) combined with an immunotherapy drug (pembrolizumab) for people with a specific type of advanced non-small cell lung cancer. It aims to see if the combination can shrink tumors or slow their growth.
Bakersfield, CaliforniaAges 18 years+ - NCT07697456RecruitingPhase 2
Study of advanced therapies for Crohn's or ulcerative colitis
This study tests advanced treatments for people with moderate to severe Crohn's disease or ulcerative colitis who haven't responded to at least one previous therapy. It aims to find better options for managing these conditions.
Dothan, AlabamaAges 18–75 - NCT07436858RecruitingPhase 1
Imaging HER2 in advanced lung cancer with a special PET scan
This study tests an imaging technique that uses a special tracer to attach to HER2 (a protein on some cancer cells) and make it visible on a PET/CT scan. The goal is to see if the tracer can help doctors understand where HER2 is in the body, which may guide future treatment options for advanced lung cancer.
Amsterdam, North HollandAges 18 years+ - NCT06771739Recruiting
Paying patients with early-stage cancer extra money
This trial is testing whether giving patients with early-stage cancer extra money to pay for non-medical needs helps them. If you are getting treatment at PeaceHealth and have some financial worries, you may be able to join.
Bellingham, WashingtonAges 18 years+ - NCT07526896Recruiting
Testing a new heart pacing method for people with heart failure
This study tests a new way to place a heart device lead to help the heart beat in sync for people with heart failure and a specific abnormal heart rhythm. The goal is to see if this method improves outcomes compared with standard treatment.
Minneapolis, MinnesotaAges 18 years+ - NCT07472517RecruitingPhase 3
Obrixtamig plus standard therapy for advanced small cell lung cancer
This trial tests whether adding a new drug, obrixtamig, to the usual first treatment for extensive-stage small cell lung cancer can help people live longer or slow the cancer's growth. The usual treatment is a combination of atezolizumab, carboplatin, and etoposide.
Mobile, AlabamaAges 18 years+ - NCT07418177RecruitingPhase 1/Phase 2
Stem cell transplant for late-stage age-related macular degeneration
This trial tests a new treatment for advanced age-related macular degeneration (AMD) where doctors transplant lab-grown retinal cells (from stem cells) under the retina to try to replace damaged cells and improve or preserve vision. It is for people with severe vision loss from either dry AMD (large area of dead tissue) or old wet AMD that has stopped leaking.
Nanjing, JiangsuAges 50–85 - NCT05934331RecruitingPhase 2
Combination therapy for advanced gastrointestinal tumors
This trial tests a new drug called LM-302 combined with other cancer treatments for people with advanced stomach, esophageal, or other gastrointestinal cancers that have stopped responding to standard first-line treatment. The goal is to see if the combination is safe and effective.
ShanghaiAges 18–80 - NCT07254585RecruitingPhase 2
Study of new drug combinations for advanced head and neck cancer
This trial tests two new drug combinations for people with head and neck cancer that has come back or spread. It aims to see if these combinations are safe and work better than current options.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06885034RecruitingPhase 1/Phase 2
Testing a new drug for advanced bowel or pancreatic cancer
This trial is testing an experimental drug (GSK5764227) either alone or with other treatments for people with advanced colon, rectal, or pancreatic cancer that cannot be removed with surgery. The goal is to see if the drug is safe and effective for these cancers.
Los Alamitos, CaliforniaAges 18 years+ - NCT07880184Recruiting
Gum healing around new lower molar implants
This study compares two ways of managing the space between a new lower molar implant and the bone. One method uses only the gum tissue, while the other uses a special graft material. The goal is to see which approach helps the implant heal better.
Al Mansurah, Dakahlia GovernorateAges 18–60 - NCT07880600Recruiting
MRI-based model to predict chemotherapy benefit for triple-negative breast cancer
This trial uses a special MRI-based computer model to predict how well chemotherapy will work before surgery for triple-negative breast cancer. It aims to help doctors tailor treatment to each patient's likely response.
Fuzhou, FujianAges 18 years+ - NCT07538115Recruiting
Better Heart Monitoring During Sedation for Digestive Procedures
This study compares two ways of monitoring your heart and vital signs during a sedated procedure to examine your digestive tract (ERCP). Researchers want to see if more detailed monitoring helps keep you safer during the procedure.
ÇorumAges 18 years+ - NCT07610837RecruitingPhase 2
Testing AZD2389 for fatty liver disease with scarring
This study tests whether a new drug called AZD2389 is safe and well-tolerated in adults with steatotic liver disease (fatty liver) that has progressed to advanced scarring. The trial aims to see if this drug might help slow or improve liver damage in people with this condition.
Chandler, ArizonaAges 18 years+ - NCT07773987RecruitingPhase 2
Immunotherapy and targeted radiation for head and neck cancer
This trial combines immunotherapy with a special type of radiation that spares healthy lymph nodes, aiming to boost the body's immune response against the tumor. It is for patients with certain types of head and neck cancer that have not spread too far and can be surgically removed.
Milwaukee, WisconsinAges 18 years+ - NCT07198074RecruitingPhase 3
Testing Avastin added to chemo plus Keytruda for certain endometrial cancer
This study tests adding Avastin (bevacizumab) to the standard combination of chemotherapy (carboplatin and paclitaxel) plus immunotherapy (Keytruda) for advanced or recurrent endometrial cancer with a specific genetic makeup (pMMR and TP53 mutation). The goal is to see if adding Avastin helps shrink tumors or slow their growth.
Birmingham, AlabamaAges 18 years+ - NCT07631325RecruitingPhase 1/Phase 2
Combination treatment for advanced melanoma that stopped responding to immunotherapy
This trial tests a new combination of drugs (axelopran and nivolumab) for people with advanced melanoma that stopped responding to earlier immunotherapy. The goal is to see if this combination can help your immune system fight the cancer again.
Pittsburgh, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for advanced or metastatic solid tumors?
- Yes. Clin2 currently lists 4,769 recruiting advanced or metastatic solid tumors studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic solid tumors trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic solid tumors trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Solid Tumors
- Advanced/Metastatic Solid Tumors
- Locally Advanced (Unresectable) or Metastatic Solid Tumors
- Locally Advanced/Metastatic Solid Tumors
- Patients With Advanced Solid Tumors
- Mesothelin-positive Advanced Malignant Solid Tumors
- Recurrent or Metastatic Solid Tumors
- Advanced Solid Tumor
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.