Clinical trials
Advanced or Metastatic Solid Tumors clinical trials
Below are recruiting advanced or metastatic solid tumors clinical trials, each written for real people, not researchers. We’re tracking 4,858 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07327788RecruitingPhase 2
Study of QL1706, bevacizumab, and chemo infusion for liver cancer with portal vein clot
This trial tests a combination of three treatments for people with advanced liver cancer that has spread into the main portal vein. The goal is to see if this therapy can shrink tumors and improve outcomes.
Guangzhou, GuangdongAges 18 years+ - NCT06638554Recruiting
Using video visits to help people get screened for lung cancer
This trial tests whether telehealth (video visits) can help more people get screened for lung cancer. It may be a good fit if you are between 50 and 80, have a history of smoking, and have not had a lung cancer screening in the last two years.
Philadelphia, PennsylvaniaAges 50–80 - NCT06106802RecruitingPhase 2
Testing lazertinib and tepotinib for EGFR lung cancer that progressed on lazertinib
This trial tests a combination of two targeted drugs, lazertinib and tepotinib, for people with advanced EGFR-mutant non-small cell lung cancer whose tumors show MET overactivity (high MET levels or MET gene copies) and have grown despite prior treatment with lazertinib. It aims to see if adding tepotinib can overcome that resistance.
Seoul, Gangnam-guAges 19 years+ - NCT06102928Recruiting
Anlotinib plus Aumolertinib for first-line treatment of advanced EGFR-mutant lung cancer
This trial tests a combination of two targeted drugs (anlotinib and aumolertinib) as the first treatment for advanced lung cancer with a specific EGFR mutation (L858R). The goal is to see if the combination works better than standard care.
Kunming, YunnanAges 18 years+ - NCT05443126RecruitingPhase 1/Phase 2
Testing a new RET drug for advanced lung cancer
This Phase 1/2 study tests lunbotinib, a new medicine that targets a specific lung-cancer change called RET. It aims to see how well it works and how safe it is for adults with advanced RET-altered non-small cell lung cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT07026422RecruitingPhase 2
Combination immunotherapy with chemoradiation for high-risk rectal cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus standard chemotherapy and radiation before surgery for people with a specific type of high-risk rectal cancer. The goal is to see if adding these drugs can improve treatment results.
Jinan, ShandongAges 18–75 - NCT07118202Recruiting
TheraBionic device for advanced liver cancer
This trial tests a device called TheraBionic P1 for people with advanced liver cancer that has not responded to other treatments. It may be an option if you have tried at least two prior therapies or cannot take standard treatments.
Bay City, MichiganAges 22 years+ - NCT06885385RecruitingPhase 2
Study of JS207 with or without JS015 and chemo for colorectal cancer
This trial tests a new drug combination (JS207 with or without JS015) along with chemotherapy for people with advanced colorectal cancer that has not spread to other parts of the body. It aims to see if the treatment is safe and helps shrink tumors.
Beijing, Beijing MunicipalityAges 18–75 - NCT07169552RecruitingPhase 2
HC010 for first-line PD-L1 positive advanced lung cancer
This trial tests a new drug called HC010 as a first treatment for people with advanced non-small cell lung cancer that is PD-L1 positive. It aims to see if the drug can help shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06989398Recruiting
ASCEND supervisor training for Dutch small businesses
This trial tests a training program for supervisors in Dutch companies with 10–250 employees. It aims to improve supervisor skills and employee well-being.
AmsterdamAges 18 years+ - NCT07613502Recruiting
Bio Leg: Advancing Mobility (BAM)
This study tests a new prosthetic leg designed to help people with above-knee amputations walk better. It may be a good fit if you already use a C-leg and can walk with a single point cane.
Jacksonville, FloridaAges 40–70 - NCT07670013RecruitingPhase 2
SKB264 and glecirasib for advanced KRAS G12C lung cancer
This trial tests a new combination of two drugs (SKB264 and glecirasib) for people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. It aims to see if this combination can shrink tumors or slow their growth.
Hangzhou, ZhejiangAges 18–75 - NCT07674732RecruitingPhase 2
Shorter radiation with immunotherapy for rectal cancer
This trial tests a shorter course of radiation followed by a combination of chemotherapy, immunotherapy, and a targeted drug (bevacizumab) for locally advanced rectal cancer that is mismatch repair proficient (pMMR) or microsatellite stable (MSS). The goal is to see if this approach can shrink the tumor enough for surgery while avoiding more extensive radiation.
Guangzhou, GuangdongAges 18–75 - NCT07648160Recruiting
Advanced Imaging Technology for Radiation Cancer Treatment
This study tests a new imaging camera that uses special dye to help doctors see tumors better during radiation therapy. It may help doctors target cancer more precisely while protecting healthy tissue.
Toronto, OntarioAges 18 years+ - NCT07589244RecruitingPhase 2/Phase 3
VRT106 with Camrelizumab and Apatinib for Advanced Liver Cancer
This study tests a combination of three drugs—VRT106 (a new oncolytic virus therapy), camrelizumab (an immune-boosting drug), and apatinib (a targeted cancer drug)—to treat advanced hepatocellular carcinoma (HCC), a type of liver cancer. The goal is to see if this combination works better than standard treatments.
Guangzhou, GuangdongAges 18–75 - NCT07500714Recruiting
Digital therapy for depression using AI
This study uses a smartphone app and artificial intelligence to deliver a special type of talk therapy for people with moderate to severe depression. It aims to provide personalized care without needing to change your current treatment.
Taichung, TaichungAges 18–75 - NCT07481448Recruiting
Long-term study of complex hip replacements
This study follows patients who have had a complex hip replacement to see how they do over time. It may help if your hip surgery was more complicated than usual, such as after prior surgeries, injuries, or certain medical conditions.
Leuven, Vlaams-BrabantAges Any age - NCT07425080Recruiting
Light treatment for IVF eggs to improve development
This trial tests whether giving brief light exposure to eggs during IVF can help more become healthy embryos. You may be eligible if you are using your own eggs for IVF and plan to transfer a genetically normal embryo soon.
New York, New YorkAges 18–48 - NCT07324785Recruiting
Link between sugar substances and stomach problems in diabetes
This study looks at how sugar-related substances (called advanced glycation end products) might affect stomach muscle function in people with diabetes who have gastroparesis (slow stomach emptying). It compares them to people without diabetes to better understand the link.
Yangzhou, JiangsuAges 18–75 - NCT07227480Recruiting
Lung cancer screening help via text message
This study uses text messages to help people get their yearly lung cancer screening. If you're between 50–80, have a significant smoking history, and haven't completed your annual screening yet, you may be able to join from home.
Rochester, New YorkAges 50–80 - NCT07155850Recruiting
Testing YntraDose before chemotherapy for advanced pancreas cancer
This trial tests a new treatment called YntraDose, given directly into the pancreas tumor before standard chemotherapy. It is for people with locally advanced pancreatic cancer that cannot be removed by surgery.
RomaAges 18 years+ - NCT07103668RecruitingPhase 3
Study of a new drug for advanced stomach cancer after prior treatments
This trial tests an experimental therapy for people with advanced stomach or gastroesophageal junction cancer that has not responded to at least two prior treatments. The therapy targets a specific protein (CLDN18.2) found on cancer cells. The goal is to see if this approach can help control the disease.
BeijingAges 18 years+ - NCT07171996Recruiting
Radioactive seed therapy for spinal tumors
This trial tests a procedure where tiny radioactive seeds are placed into spinal tumors to relieve pain and control growth. It is for people with cancer that has spread to the bone and who are able to undergo the procedure safely.
Jinan, ShandongAges 18–55 - NCT07051330Recruiting
Personalized training for depression symptoms
This study tests a personalized training program for people with mild to moderate depression symptoms. It uses a smartphone app and text messages to help improve mood and well-being.
Madison, WisconsinAges 18 years+
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Common questions
- Are there clinical trials for advanced or metastatic solid tumors?
- Yes. Clin2 currently lists 4,858 recruiting advanced or metastatic solid tumors studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic solid tumors trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic solid tumors trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Solid Tumors
- Advanced/Metastatic Solid Tumors
- Locally Advanced (Unresectable) or Metastatic Solid Tumors
- Locally Advanced/Metastatic Solid Tumors
- Patients With Advanced Solid Tumors
- Mesothelin-positive Advanced Malignant Solid Tumors
- Recurrent or Metastatic Solid Tumors
- Advanced Solid Tumor
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.