Clinical trials
Amputee clinical trials
Below are recruiting amputee clinical trials, each written for real people, not researchers. We’re tracking 27 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06753110Recruiting
Long-term safety of OPRA implant for arm amputees
This study checks the long-term safety and how well the OPRA implant (a bone-anchored prosthetic) works for people who have an arm amputation. It is for those who already have the implant and had their second surgery at least six months ago.
Melbourne, VictoriaAges Any age - NCT06424249Recruiting
Virtual reality vs. standard rehab for balance after below-knee amputation
This study compares virtual reality exercises to standard physical therapy for improving balance in people with one leg amputated below the knee. It may help you regain better balance and confidence in walking.
Le Grau-du-RoiAges 18–80 - NCT04839497RecruitingPhase 2
Safety and benefit of injecting fibroblast cells in leg amputees’ skin
This Phase 2 study tests whether injecting a patient’s own (autologous) fibroblast cells into the end of a transtibial (below-knee) amputation is safe and may improve outcomes. You may qualify if you have a certain type of prosthesis timing and healthy skin on the stump, and you can follow frequent visit and wound-care instructions.
Baltimore, MarylandAges 18–75 - NCT04430218Recruiting
Peripheral interfaces for better prosthetic arm control
This trial tests a surgically placed device that connects to arm nerves to improve control and feeling in a prosthetic arm. It may help people with upper limb amputations who already use or are prescribed a myoelectric prosthesis.
Cleveland, OhioAges 21 years+ - NCT07875075Recruiting
Core muscle and balance study for lower limb amputees
This study looks at how core muscle function and balance work in people with a single leg amputation who use a prosthesis. It aims to understand how these factors affect daily activities and may help improve rehabilitation.
Balçova, İzmirAges 20–60 - NCT06433648Recruiting
Powered knee study for above-knee amputee walkers
This study looks at how a powered (motorized) prosthetic knee joint affects walking in people with one above-knee amputation. It aims to find out if the powered knee makes walking easier or more natural.
Chicago, IllinoisAges 18–95 - NCT07840781Recruiting
Building a performance model for amputee football players
This study aims to understand what makes amputee football players perform well, so it can help improve training and performance. If you play amputee football regularly, you may be able to join and contribute to this research.
AdanaAges Any age - NCT07691957Recruiting
Nerve study for healthy and amputee volunteers
This study uses a special technique to measure how nerves in the arm send signals to the brain. It compares healthy volunteers and people with an upper-limb amputation to better understand sensation and potentially improve prosthetic devices.
Pisa, PisaAges 18–60 - NCT07685496Recruiting
How shoes affect walking for below-knee amputees
This study looks at how different types of footwear affect walking in people with a below-knee amputation. If you use a specific energy-returning prosthetic foot and can walk without aids, you may be able to join and help improve understanding of what shoes work best.
Manchester, Greate ManchesterAges 18–65 - NCT06648798Recruiting
Comparing a new fast-fit prosthetic leg to your current one
This trial is testing a new quick-to-make, custom below-knee prosthetic leg (called the UniLeg). It compares how well it works for daily walking versus your current prosthetic. The goal is to see if the new leg can be made faster and fit better, helping you stay active.
La Jolla, CaliforniaAges 18–75 - NCT07613502Recruiting
Bio Leg: Advancing Mobility (BAM)
This study tests a new prosthetic leg designed to help people with above-knee amputations walk better. It may be a good fit if you already use a C-leg and can walk with a single point cane.
Jacksonville, FloridaAges 40–70 - NCT07486063RecruitingEarly Phase 1
Motorized leg prosthetics for above-knee amputees
This study tests whether a motorized (powered) prosthetic knee and ankle can help people with above-knee amputations walk better. If you already use a mechanical or microprocessor-controlled leg, you may be able to try a new powered version.
Salt Lake City, UtahAges 18–80 - NCT07448350Recruiting
TENS therapy for better sensation after leg amputation
This study tests if a gentle electrical stimulation method called TENS can help people who have lost a leg below or above the knee feel more natural sensations in their missing limb and reduce phantom limb pain.
Rome, RomeAges 18–80 - NCT07418645Recruiting
Touch feedback system for arm amputees
This study tests a new system that gives you touch sensations through a prosthetic hand. It aims to help you feel more connected to the device and improve how you use it.
Pisa, PIAges 18–80 - NCT07420192Recruiting
A study on nerve surgery for pain after leg amputation
This trial tests a surgery called RPNI to treat painful nerve growths (neuromas) in people who have lost a leg. The goal is to reduce severe pain and improve the ability to use a prosthetic limb.
Ankara, AnkaraAges 18–70 - NCT07216183RecruitingPhase 1
Skin sensor study for lower leg amputees
This study tests a new wireless skin sensor that sticks to your residual limb (the part of your leg below the knee where you wear your prosthetic). The goal is to track how your skin is doing inside the socket. If you qualify, you'll visit North Carolina State University to try the sensor and be photographed during research activities.
Raleigh, North CarolinaAges 18–75 - NCT07191795Recruiting
Using phantom sensations from socket changes as feedback while walking
This trial tests whether changing how your prosthetic socket fits can create helpful phantom limb sensations that improve your walking. It may help people with major lower-limb amputations walk more naturally.
NancyAges 18 years+ - NCT07164846Recruiting
FES suit for recovery after injury or amputation
This trial tests a special suit that uses mild electrical stimulation to help improve muscle strength, walking, and body functions. It may help people who are at least one week past an amputation or a nervous system injury like stroke or spinal cord injury.
Jacksonville, FloridaAges 18 years+ - NCT07032233Recruiting
Strength, Balance, and Function in Above-Knee Amputees
This study looks at how the length of the remaining part of your leg (residual limb) affects your strength, balance, and walking ability. If you have a transfemoral amputation (above the knee) and use a prosthesis, this trial may help researchers better understand your function.
Ankara, AnkaraAges 18–50 - NCT06635655Recruiting
Testing a new prosthetic knee for mental ease
This study tests whether a new prosthetic knee system helps reduce mental effort while walking for people with above-knee amputations. If you use a prosthetic leg and are comfortable with a smartphone, you may be able to join.
Multiple LocationsAges 18–84 - NCT06194838Recruiting
Mechanical vs. powered knee for above-knee amputees
This study compares a non-powered (mechanical) knee to a powered (battery-assisted) knee for people with above-knee amputations who walk at a moderate level (K2). It will help find out which knee type works better for your daily activities and mobility.
Austin, TexasAges 18 years+ - NCT05990062Recruiting
Better fitting prosthetic arms for amputees
This study is testing a new way to design prosthetic arms to make them fit better and work more naturally. It may help people who have used a prosthetic arm before and are looking for a more comfortable and functional device.
Pittsburgh, PennsylvaniaAges Any age - NCT04947462Recruiting
Improved control of prosthetic arms with hand nerve signals
This study tests a new way to connect nerve signals from your amputated arm to a prosthetic hand, which may help you control it more naturally and feel what the hand is touching.
Cleveland, OhioAges 18 years+ - NCT04750876Recruiting
Psychological and physical therapy follow-up after leg amputation
This trial tests whether adding both psychological support and physical therapy check-ins before and after leg amputation improves recovery and rehab planning. It may help patients feel better and regain function during the transition to rehabilitation care.
La Roche-sur-YonAges 18 years+
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Common questions
- Are there clinical trials for amputee?
- Yes. Clin2 currently lists 27 recruiting amputee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.