Clinical trials
Amputee clinical trials
Below are recruiting amputee clinical trials, each written for real people, not researchers. We’re tracking 30 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06849934Enrolling by invitation
Testing software for knee movement in below-knee amputees
This study tests whether a computer program called Kinovea can accurately measure how your knee moves while walking. If you have a below-knee amputation, use a prosthetic, and meet a few health criteria, you may be able to help improve how amputees are fitted and trained.
AnkaraAges 18–65 - NCT04430218Recruiting
Peripheral interfaces for better prosthetic arm control
This trial tests a surgically placed device that connects to arm nerves to improve control and feeling in a prosthetic arm. It may help people with upper limb amputations who already use or are prescribed a myoelectric prosthesis.
Cleveland, OhioAges 21 years+ - NCT04839497RecruitingPhase 2
Safety and benefit of injecting fibroblast cells in leg amputees’ skin
This Phase 2 study tests whether injecting a patient’s own (autologous) fibroblast cells into the end of a transtibial (below-knee) amputation is safe and may improve outcomes. You may qualify if you have a certain type of prosthesis timing and healthy skin on the stump, and you can follow frequent visit and wound-care instructions.
Baltimore, MarylandAges 18–75 - NCT06424249Recruiting
Virtual reality vs. standard rehab for balance after below-knee amputation
This study compares virtual reality exercises to standard physical therapy for improving balance in people with one leg amputated below the knee. It may help you regain better balance and confidence in walking.
Le Grau-du-RoiAges 18–80 - NCT06948695Recruiting
Running study for people with one leg amputation below the knee
This trial studies how running with a sports blade affects your body's movement and energy use. It may help improve training and blade design for runners with a below-knee amputation.
Saint-EtienneAges 18–65 - NCT07578051Recruiting
Two approaches to gait training for above-knee amputees
This study compares two methods of physical therapy for people with above-knee (thighbone) amputations: one focuses on improving specific movements, the other on practicing everyday walking tasks. Researchers want to see which approach helps patients walk better with a prosthetic leg.
Islamabad, Punjab ProvinceAges 18–40 - NCT06753110Recruiting
Long-term safety of OPRA implant for arm amputees
This study checks the long-term safety and how well the OPRA implant (a bone-anchored prosthetic) works for people who have an arm amputation. It is for those who already have the implant and had their second surgery at least six months ago.
Melbourne, VictoriaAges Any age - NCT03135847Enrolling by invitation
Using feedback to improve prosthetic movement in amputees
This study tests whether movement “feedback” can help adults with arm or leg amputations control a prosthetic better. It may be most helpful if you can comfortably wear a prosthetic socket and can understand and consent to the study.
Ages 18–75 - NCT04947462Recruiting
Improved control of prosthetic arms with hand nerve signals
This study tests a new way to connect nerve signals from your amputated arm to a prosthetic hand, which may help you control it more naturally and feel what the hand is touching.
Cleveland, OhioAges 18 years+ - NCT07685496Recruiting
How shoes affect walking for below-knee amputees
This study looks at how different types of footwear affect walking in people with a below-knee amputation. If you use a specific energy-returning prosthetic foot and can walk without aids, you may be able to join and help improve understanding of what shoes work best.
Manchester, Greate ManchesterAges 18–65 - NCT04750876Recruiting
Psychological and physical therapy follow-up after leg amputation
This trial tests whether adding both psychological support and physical therapy check-ins before and after leg amputation improves recovery and rehab planning. It may help patients feel better and regain function during the transition to rehabilitation care.
La Roche-sur-YonAges 18 years+ - NCT06486571Recruiting
Study of a better robotic hand with feeling
This trial tests a new way to control a robotic hand using sensors on your skin and to give you feeling back through mild electrical pulses. It may help people with upper limb amputations have a more natural sense of touch and control.
Budrio, BOAges 18–65 - NCT07448350Recruiting
TENS therapy for better sensation after leg amputation
This study tests if a gentle electrical stimulation method called TENS can help people who have lost a leg below or above the knee feel more natural sensations in their missing limb and reduce phantom limb pain.
Rome, RomeAges 18–80 - NCT05990062Recruiting
Better fitting prosthetic arms for amputees
This study is testing a new way to design prosthetic arms to make them fit better and work more naturally. It may help people who have used a prosthetic arm before and are looking for a more comfortable and functional device.
Pittsburgh, PennsylvaniaAges Any age - NCT07195461RecruitingEarly Phase 1
Magnetic beads helping control a robotic leg
This trial tests a new system that uses tiny magnetic beads to help a robotic leg move more naturally. It aims to improve function for people who need a below-knee amputation or already have one that needs fixing.
Boston, MassachusettsAges 22–65 - NCT03947450RecruitingPhase 2
Injection of your own skin cells into below-knee amputation site
This Phase 2 study tests whether injecting a patient’s own fibroblast cells (skin-support cells) into the wound area after a below-knee amputation can help the stump skin heal and work better. It’s intended for people who already have (or are close to having) a prosthetic fitting.
Baltimore, MarylandAges 18–65 - NCT06648798Recruiting
Comparing a new fast-fit prosthetic leg to your current one
This trial is testing a new quick-to-make, custom below-knee prosthetic leg (called the UniLeg). It compares how well it works for daily walking versus your current prosthetic. The goal is to see if the new leg can be made faster and fit better, helping you stay active.
La Jolla, CaliforniaAges 18–75 - NCT07613502Recruiting
Bio Leg: Advancing Mobility (BAM)
This study tests a new prosthetic leg designed to help people with above-knee amputations walk better. It may be a good fit if you already use a C-leg and can walk with a single point cane.
Jacksonville, FloridaAges 40–70 - NCT03409133Recruiting
Neural feedback training for people with leg amputations
This study tests whether a nerve-based “feedback” system can help people with below-knee or above-knee amputations during standing and walking. It focuses on whether the training and device setup are safe and workable for participants over the study period.
Cleveland, OhioAges 18 years+ - NCT04953364Recruiting
Tech-based self-management support after a leg amputation
This study tests a technology-based program to help people manage rehabilitation after a lower-limb amputation. It may help by giving structured support for day-to-day care and prosthesis use.
Vancouver, British ColumbiaAges 50 years+ - NCT06194838Recruiting
Mechanical vs. powered knee for above-knee amputees
This study compares a non-powered (mechanical) knee to a powered (battery-assisted) knee for people with above-knee amputations who walk at a moderate level (K2). It will help find out which knee type works better for your daily activities and mobility.
Austin, TexasAges 18 years+ - NCT06433648Recruiting
Powered knee study for above-knee amputee walkers
This study looks at how a powered (motorized) prosthetic knee joint affects walking in people with one above-knee amputation. It aims to find out if the powered knee makes walking easier or more natural.
Chicago, IllinoisAges 18–95 - NCT07691957Recruiting
Nerve study for healthy and amputee volunteers
This study uses a special technique to measure how nerves in the arm send signals to the brain. It compares healthy volunteers and people with an upper-limb amputation to better understand sensation and potentially improve prosthetic devices.
Pisa, PisaAges 18–60 - NCT06635655Recruiting
Testing a new prosthetic knee for mental ease
This study tests whether a new prosthetic knee system helps reduce mental effort while walking for people with above-knee amputations. If you use a prosthetic leg and are comfortable with a smartphone, you may be able to join.
Multiple LocationsAges 18–84
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Common questions
- Are there clinical trials for amputee?
- Yes. Clin2 currently lists 30 recruiting amputee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.