Clinical trials
Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 190 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05352958Recruiting
Ultrasound checks breathing muscle function in ALS
This study uses a quick ultrasound test to check how well the breathing muscle (the diaphragm) works in people with amyotrophic lateral sclerosis (ALS). It may help doctors monitor breathing changes over time and guide care.
DijonAges 18 years+ - NCT05407324RecruitingPhase 2
Dazucorilant for ALS patients at higher risk of faster progression
This Phase 2 study tests whether dazucorilant can slow or improve outcomes in people with amyotrophic lateral sclerosis (ALS) who are likely to progress more quickly. You may be able to join if you meet specific ALS type and risk-score requirements and your health tests and medications fit the study rules.
Phoenix, ArizonaAges 18 years+ - NCT05474235Recruiting
ALS and motor neuron disease studies for patients, family, and controls
This study looks at people with amyotrophic lateral sclerosis (ALS), people who might have ALS, and also people related to someone with ALS. It may help researchers better understand ALS and related “motor neuron” conditions, and it involves participation that may include blood tests.
Jacksonville, FloridaAges 18 years+ - NCT05819931Recruiting
Breathing support sessions for ALS using MIE
This study looks at breathing support sessions using a machine called MIE to help people with amyotrophic lateral sclerosis (ALS). It may help reduce breathing complications for people who haven’t benefited from similar breathing sessions in the last year.
Toulouse, OccitanieAges 18–100 - NCT06021938Recruiting
Virtual Reality for Breathlessness in ALS
This trial tests if using immersive virtual reality can help reduce ongoing shortness of breath in people with ALS who already use a breathing mask (non-invasive ventilation). It may offer a drug-free way to feel more comfortable.
Paris, FranceAges 18 years+ - NCT06083584Recruiting
Using RNA test to help diagnose ALS
This study is developing a new RNA test to improve the accuracy of diagnosing amyotrophic lateral sclerosis (ALS). It aims to see if this test can help doctors make a clearer and faster diagnosis.
BordeauxAges 18 years+ - NCT06228001Recruiting
Movement monitoring in ALS patients
This study uses a wearable device to track movement patterns in people with ALS. It aims to better understand how the disease affects movement over time, which may help improve care.
LeuvenAges 18 years+ - NCT06318598Recruiting
ALS and motor neuron disease biomarker study
This study looks for biological markers in people with ALS or other motor neuron diseases to better understand the different types of the disease. It may help find new ways to treat or manage these conditions.
Milan, MIAges 18 years+ - NCT06344260RecruitingPhase 2
Neural stem cell therapy for ALS: a phase 2 trial
This trial tests whether injecting neural stem cells into the spine can slow down ALS. It is for people with rapidly progressing ALS who have good lung function and a caregiver to help with visits.
San Giovanni Rotondo, FoggiaAges 18–65 - NCT06450691Recruiting
ALS Study: Using Skin Cells to Understand the Disease
This study collects a small skin sample (biopsy) from people with ALS, those who carry an ALS gene mutation but have no symptoms, and healthy volunteers. The sample is used to grow cells in the lab to better understand how ALS develops.
ParisAges 18 years+ - NCT06551649Recruiting
Test of cell-based treatment for ALS and MS
This study tests a therapy made from human amniotic cells to help reduce brain inflammation and damage. It may be an option for people with ALS or multiple sclerosis who meet the age and health requirements, as well as healthy volunteers to serve as a comparison group.
RomaAges 20–60 - NCT06556394RecruitingPhase 1
Testing RAG-17 for ALS with SOD1 gene mutation
This trial tests a new drug, RAG-17, for people with ALS who have a specific SOD1 gene mutation. The goal is to see if it's safe and how it affects the body, which may help slow the disease.
BeijingAges 18 years+ - NCT06608004Recruiting
Taste and smell impact on nutrition in ALS
This study looks at how sense of smell and taste affect the nutritional health of people with ALS. If you have early-stage ALS and want to help doctors learn how to support better eating, this may be for you.
DijonAges 18 years+ - NCT06649955Recruiting
Controlling nerve activity in ALS with brain stimulation
This study tests a non-invasive brain stimulation technique (called transcutaneous spinal direct current stimulation and transcranial magnetic stimulation) to see if it can calm overactive nerves in people with ALS. You may be a good fit if you have ALS that started less than 3 years ago and your breathing is still strong.
Boston, MassachusettsAges 18–80 - NCT06668649Recruiting
Polish fatigue scale study for MS, ALS, or stroke
This study tests a Polish version of a scale that measures how tired people feel. It's for people with MS, ALS, or stroke, or healthy volunteers.
Krakow, Lesser Poland VoivodeshipAges 18 years+ - NCT06726577RecruitingPhase 1/Phase 2
A new drug for ALS: phase 1/2 safety and effectiveness trial
This trial tests a new drug called TP04HN106 for people with ALS. It aims to see if it is safe and if it might slow down the disease. You may qualify if your breathing is still fairly good and you have been on a stable dose of riluzole.
Suzhou, JiangsuAges 18 years+ - NCT06782724RecruitingPhase 2
Psilocybin therapy for distress in advanced illness
This trial tests whether a single dose of psilocybin (a psychedelic medicine) can help reduce depression and distress in people with advanced lung disease, ALS, multiple sclerosis, or Parkinson's. You would receive preparation, the drug, and follow-up support in a safe, supervised setting.
PragueAges 18 years+ - NCT06820008Recruiting
Using smartphones to track physical changes in ALS
This study uses smartphone apps and digital tools to track physical changes in people with ALS. It aims to better understand how the disease affects daily function, which could help improve future care.
Dublin, DublinAges 18 years+ - NCT06834269Recruiting
Magnetic stimulation for ALS: a study on slowing progression
This study tests a gentle, non-invasive magnetic stimulation applied to the head to see if it can slow the progression of ALS. It uses a special device that creates a static magnetic field, and researchers will also look for biomarkers in your body that may help predict how the disease will progress.
Roma, RMAges 18 years+ - NCT06885918Recruiting
ALS Research Collaborative study
This study is a research collaborative that collects information from people with ALS or their families. It aims to better understand the disease and find markers that could help develop treatments.
Watertown, MassachusettsAges 18 years+ - NCT07006571Recruiting
At-home brain stimulation for ALS
This study tests if a gentle electrical stimulation device applied at home can help slow ALS progression. It is for people with ALS who were diagnosed within the last 2 years and have a caregiver to assist with the device.
Trieste, TriesteAges 18 years+ - NCT07071935RecruitingPhase 2
Early ventilation study for newly diagnosed ALS
This trial tests whether starting non-invasive ventilation (breathing support) early in ALS helps people breathe easier and live better. If you've been diagnosed with ALS in the last 6 months and haven't used a breathing machine before, you may qualify.
Hershey, PennsylvaniaAges 18 years+ - NCT07091799Recruiting
Blood test to diagnose ALS using P2X4 markers
This study looks at a protein called P2X4 on immune cells in your blood to see if it can help diagnose ALS. You would give a blood sample to help researchers find a new way to identify ALS.
BordeauxAges 18 years+ - NCT07100119RecruitingPhase 1
Study of LY4256984 for people with sporadic ALS
This trial tests a new medicine called LY4256984 for people with sporadic ALS (ALS not caused by a known genetic mutation). The goal is to see if the drug is safe and how it affects the body. It may offer a new treatment option for people recently diagnosed with ALS.
LeuvenAges 18–75
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Common questions
- Are there clinical trials for amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 190 recruiting amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.