Clinical trials
Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 186 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07341984Recruiting
Exercise study for people with ALS
This study tests whether a personalized exercise program, done 3 to 5 times a week for 30 minutes each, can help people with ALS maintain strength and function. It aims to see if tailored physical therapy is safe and beneficial.
Sankt GallenAges Any age - NCT07295990Recruiting
Tongue exercises for people with ALS
This trial tests whether simple tongue-strengthening exercises can help people with ALS who have mild swallowing trouble. If you have ALS and notice your tongue getting weaker, this study may help you keep your swallowing strength.
Davie, FloridaAges 18–99 - NCT07290062RecruitingPhase 1
Gene therapy injection for ALS safety study
This trial tests a single injection of a gene therapy called INS1202 into the spinal fluid. It is for people with ALS, including those with a specific genetic form (SOD1 mutation). The goal is to see if it is safe and how it affects the body.
La Jolla, CaliforniaAges 18–79 - NCT06885918Recruiting
ALS Research Collaborative study
This study is a research collaborative that collects information from people with ALS or their families. It aims to better understand the disease and find markers that could help develop treatments.
Watertown, MassachusettsAges 18 years+ - NCT07259980Recruiting
Long-term safety of tofersen for SOD-1 ALS
This study checks the long-term safety of the drug tofersen (also known as Qalsody) for people with a specific genetic type of ALS caused by SOD1 mutations. It aims to make sure the drug is safe over time by watching participants from registry networks.
Boston, MassachusettsAges 18 years+ - NCT07257302Recruiting
Breathing muscle training for ALS patients
This study tests whether a special breathing exercise called Lung Insufflation Capacity (LIC) training can help people with ALS maintain or improve their breathing muscle strength. Participants must be age 20 or older, have a confirmed ALS diagnosis, and not be using a breathing machine at the start of the training.
Kodaira, TokyoAges 20 years+ - NCT07233148Recruiting
ALS, MND, or PLS registry study
This observational study creates a registry for people with ALS, MND, or PLS. It helps researchers better understand these conditions and find possible treatments.
Park City, UtahAges 18–110 - NCT07224269RecruitingEarly Phase 1
Terazosin for energy in ALS patients
This study tests whether a medication called terazosin can boost energy levels in people with ALS (Lou Gehrig's disease). The goal is to see if it helps slow down the disease by supporting cell energy.
Iowa City, IowaAges 18–80 - NCT07221240RecruitingPhase 1
Amisodin safety study for healthy adults with ALS
This trial tests a new drug called Amisodin in healthy adults who also have ALS. It checks if the drug is safe and how the body processes it.
Baltimore, MarylandAges 18–55 - NCT07204977RecruitingPhase 1
Acamprosate for ALS with C9orf72 gene change
This trial tests a medication called acamprosate to see if it can slow down ALS in people who have a specific genetic change (C9orf72). If you have this gene change and ALS, this study might offer a new treatment option.
Bethesda, MarylandAges 18–99 - NCT07187388Recruiting
Electrical stimulation for jaw pain in motor neuron disease
This study tests whether gentle electrical stimulation around the jaw can ease facial pain, improve jaw movement, and help oral health in people with certain motor neuron diseases like ALS or PLS. It may be a good fit if you have jaw pain and meet a few health conditions.
Davie, FloridaAges 18 years+ - NCT07175935Recruiting
ALS patient registry in Thailand
This study will create a registry of people with ALS in Thailand. The goal is to track the disease and to improve the care and treatment for future patients.
Pathum Wan, BangkokAges Any age - NCT06318598Recruiting
ALS and motor neuron disease biomarker study
This study looks for biological markers in people with ALS or other motor neuron diseases to better understand the different types of the disease. It may help find new ways to treat or manage these conditions.
Milan, MIAges 18 years+ - NCT07118319RecruitingPhase 1
Stem cell therapy safety trial for ALS
This trial tests a new treatment made from stem cells (called XS228CN) injected into the spine. It is primarily a safety study, but doctors will also watch for any signs the treatment may slow ALS progression.
Beijing, Beijing MunicipalityAges 18–75 - NCT07100119RecruitingPhase 1
Study of LY4256984 for people with sporadic ALS
This trial tests a new medicine called LY4256984 for people with sporadic ALS (ALS not caused by a known genetic mutation). The goal is to see if the drug is safe and how it affects the body. It may offer a new treatment option for people recently diagnosed with ALS.
LeuvenAges 18–75 - NCT05352958Recruiting
Ultrasound checks breathing muscle function in ALS
This study uses a quick ultrasound test to check how well the breathing muscle (the diaphragm) works in people with amyotrophic lateral sclerosis (ALS). It may help doctors monitor breathing changes over time and guide care.
DijonAges 18 years+ - NCT07091799Recruiting
Blood test to diagnose ALS using P2X4 markers
This study looks at a protein called P2X4 on immune cells in your blood to see if it can help diagnose ALS. You would give a blood sample to help researchers find a new way to identify ALS.
BordeauxAges 18 years+ - NCT07082192RecruitingPhase 2/Phase 3
Testing CB03-154 for adults with ALS
This trial tests a new medicine, CB03-154, to see if it can help people with ALS. Researchers are comparing different doses to find the safest and most effective one.
Beijing, Beijing MunicipalityAges 18–65 - NCT06228001Recruiting
Movement monitoring in ALS patients
This study uses a wearable device to track movement patterns in people with ALS. It aims to better understand how the disease affects movement over time, which may help improve care.
LeuvenAges 18 years+ - NCT06083584Recruiting
Using RNA test to help diagnose ALS
This study is developing a new RNA test to improve the accuracy of diagnosing amyotrophic lateral sclerosis (ALS). It aims to see if this test can help doctors make a clearer and faster diagnosis.
BordeauxAges 18 years+ - NCT07071935RecruitingPhase 2
Early ventilation study for newly diagnosed ALS
This trial tests whether starting non-invasive ventilation (breathing support) early in ALS helps people breathe easier and live better. If you've been diagnosed with ALS in the last 6 months and haven't used a breathing machine before, you may qualify.
Hershey, PennsylvaniaAges 18 years+ - NCT07023835RecruitingPhase 2
Testing usnoflast for ALS
This trial tests an experimental oral medication called usnoflast for people with ALS. It aims to see if the drug can slow the disease's progression.
La Jolla, CaliforniaAges 18 years+ - NCT07006571Recruiting
At-home brain stimulation for ALS
This study tests if a gentle electrical stimulation device applied at home can help slow ALS progression. It is for people with ALS who were diagnosed within the last 2 years and have a caregiver to assist with the device.
Trieste, TriesteAges 18 years+ - NCT06782724RecruitingPhase 2
Psilocybin therapy for distress in advanced illness
This trial tests whether a single dose of psilocybin (a psychedelic medicine) can help reduce depression and distress in people with advanced lung disease, ALS, multiple sclerosis, or Parkinson's. You would receive preparation, the drug, and follow-up support in a safe, supervised setting.
PragueAges 18 years+
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Common questions
- Are there clinical trials for amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 186 recruiting amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.