Clinical trials
Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 186 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05744310Recruiting
Long-term ventilation support and quality of life in ALS
This study looks at how long-term breathing support (a ventilation device used over time) affects quality of life for people with ALS and their families. It also asks family members and children about day-to-day well-being during this treatment period.
Bodø, NordlandAges 8 years+ - NCT04882904Recruiting
Tracking movement in people with ALS and healthy volunteers
This study continuously measures activity and movement in people with ALS and in control participants. It aims to better understand how muscle disease changes day-to-day function, which may help improve future monitoring or care.
Liège, LiègeAges 18 years+ - NCT05116943Recruiting
ALS and related brain disease biospecimen biobank
This study builds a blood and spinal fluid (lumbar puncture) sample library from people with ALS, ALS-FTD, or similar neurodegenerative diseases. Your samples help researchers study these conditions, even if you are not receiving a new treatment.
Jacksonville, FloridaAges 18 years+ - NCT05370079Recruiting
Control group for people with specific serious illnesses
This trial includes a “control” group of people with certain diseases to compare outcomes against another group. If you qualify, you may receive the standard approach used in usual care rather than the experimental treatment.
BronAges 18 years+ - NCT05336760Recruiting
ALS study of swallowing comfort, quality of life, and PEG views
This study looks at swallowing problems in people with ALS and how they affect quality of life, including people’s attitudes toward PEG (a feeding tube). It may help researchers understand what support and information could improve comfort and day-to-day living.
LjubljanaAges 18 years+ - NCT05067179Recruiting
ALS patient data and tissue study
This study collects information from people diagnosed with ALS and, if applicable, studies ALS tissue samples. It aims to improve understanding of ALS using patient records and donated materials, which may help future treatments.
Chicago, IllinoisAges 18–90 - NCT05104710Recruiting
Testing brain–muscle coordination as a marker in ALS
This study measures how well your nerves and muscles work together to see if it can serve as an early sign (a “biomarker”) of ALS. It may help doctors track ALS more accurately, especially in people who already seem to have ALS based on nerve testing.
Irvine, CaliforniaAges 20–90 - NCT04961450Enrolling by invitation
Study tracking brain illness markers in motor neuron and frontotemporal disease
This study looks for “biomarkers” (measurable signs in blood or other samples) in people with motor neuron disease and frontotemporal dementia spectrum conditions. It also compares those findings with matched caregivers, to understand what might be happening in these diseases.
Beijing, Beijing MunicipalityAges 18–80 - NCT03865420Recruiting
Genetic risk study for families affected by ALS
This study looks at genetic risk for amyotrophic lateral sclerosis (ALS) in families. It may help researchers understand who carries ALS-related gene changes and how that affects future care.
New York, New YorkAges 18–105 - NCT04816227Recruiting
Study of immune cells in ALS and related movement problems
This study looks at immune cells (called macrophages) from people with ALS and certain related movement or nerve conditions. It aims to better understand how the disease works and may help researchers design future treatments.
ParisAges 18 years+ - NCT04715399Recruiting
Research study collecting data for neurodegenerative diseases
This study collects health information from people with neurodegenerative diseases, some family members, and healthy controls to help researchers better understand these conditions. It may help future diagnosis and research, and participation may include noninvasive checks and other procedures depending on your situation.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04302870RecruitingPhase 2/Phase 3
Test medicines for motor neurone disease using adaptive trial design
This study tests treatments for motor neurone disease (MND) and assigns people to different treatment arms in an adaptive way. It may help doctors find out which medicine works best and for whom.
Portadown, County ArmaghAges 18 years+ - NCT04220190RecruitingPhase 2/Phase 3
Study drug made from your immune cells for ALS
This trial tests RAPA-501, a treatment made using your own immune cells, to slow progression of ALS. It may help by changing how your immune system responds in ALS.
Boston, MassachusettsAges 18 years+ - NCT03567213Recruiting
CortiCom brain signal system for communication in severe paralysis
This trial tests a system that records brain signals to help people with severe paralysis and little or no speech communicate. It involves a surgical implant and frequent study visits to see if the system can work safely and reliably for communication.
Baltimore, MarylandAges 22–70 - NCT03174938Recruiting
BioFINDER 2 study for healthy aging and memory problems
This study uses brain scans and a spinal fluid test to better understand memory and thinking changes in different groups, from people with healthy thinking to early or established dementia. If you qualify, it may help researchers learn what’s driving these conditions and how they progress.
ÄngelholmAges 20–100 - NCT02795052Recruiting
Stem cell treatment trial for nerve injury
This study tests whether bone-marrow stem cells can improve nerve function in people with nerve damage that usually doesn’t recover with current care. It also checks whether the treatment is safe and whether people can be followed over time with repeated nerve exams.
Westport, ConnecticutAges 18 years+ - NCT00136500Recruiting
Research study for people with ALS and family risk
This study looks at people affected by ALS (a nerve disease) and, in some cases, family members who may be at genetic risk. It may help researchers better understand ALS and related conditions and improve how they’re studied.
Miami, FloridaAges 18 years+ - NCT00912041Recruiting
Test of a brain-to-computer device for quadriplegia
This study tests whether a tiny brain computer interface can help people with quadriplegia (loss of movement in all four limbs) communicate or control technology. It’s mainly a feasibility study, meaning the goal is to see if the device can work safely and reliably in real life.
Sacramento, CaliforniaAges 18–80
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Common questions
- Are there clinical trials for amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 186 recruiting amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.