Clinical trials
Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 189 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07187388Recruiting
Electrical stimulation for jaw pain in motor neuron disease
This study tests whether gentle electrical stimulation around the jaw can ease facial pain, improve jaw movement, and help oral health in people with certain motor neuron diseases like ALS or PLS. It may be a good fit if you have jaw pain and meet a few health conditions.
Davie, FloridaAges 18 years+ - NCT07221240RecruitingPhase 1
Amisodin safety study for healthy adults with ALS
This trial tests a new drug called Amisodin in healthy adults who also have ALS. It checks if the drug is safe and how the body processes it.
Baltimore, MarylandAges 18–55 - NCT07223723RecruitingPhase 4
Long-term safety of tofersen for SOD1 ALS in China
This study tests the long-term safety of an investigational drug called tofersen (Qalsody) for people in China who have a specific type of ALS caused by a change in the SOD1 gene. If you qualify, you will receive the drug and be monitored for side effects over time.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07233148Recruiting
ALS, MND, or PLS registry study
This observational study creates a registry for people with ALS, MND, or PLS. It helps researchers better understand these conditions and find possible treatments.
Park City, UtahAges 18–110 - NCT07259980Recruiting
Long-term safety of tofersen for SOD-1 ALS
This study checks the long-term safety of the drug tofersen (also known as Qalsody) for people with a specific genetic type of ALS caused by SOD1 mutations. It aims to make sure the drug is safe over time by watching participants from registry networks.
Boston, MassachusettsAges 18 years+ - NCT07290062RecruitingPhase 1
Gene therapy injection for ALS safety study
This trial tests a single injection of a gene therapy called INS1202 into the spinal fluid. It is for people with ALS, including those with a specific genetic form (SOD1 mutation). The goal is to see if it is safe and how it affects the body.
La Jolla, CaliforniaAges 18–79 - NCT07295990Recruiting
Tongue exercises for people with ALS
This trial tests whether simple tongue-strengthening exercises can help people with ALS who have mild swallowing trouble. If you have ALS and notice your tongue getting weaker, this study may help you keep your swallowing strength.
Davie, FloridaAges 18–99 - NCT07341984Recruiting
Exercise study for people with ALS
This study tests whether a personalized exercise program, done 3 to 5 times a week for 30 minutes each, can help people with ALS maintain strength and function. It aims to see if tailored physical therapy is safe and beneficial.
Sankt GallenAges Any age - NCT07369076RecruitingPhase 1/Phase 2
Testing NB-4746 for people with ALS
This study tests an investigational drug called NB-4746 for people with ALS. The goal is to see if it can slow the progression of the disease. It is for people diagnosed within the last couple of years who are still able to eat and breathe on their own.
Concord, New South WalesAges 18–80 - NCT00317616Recruiting
Study for people at high risk of ALS before symptoms start
This study follows healthy people from families with a known ALS-causing gene mutation to look for early body or brain changes before symptoms begin. It may help researchers find ways to predict ALS risk earlier so future treatments can start sooner.
Miami, FloridaAges 18 years+ - NCT01772602Recruiting
Join a national ALS patient registry in the U.S.
This study is a national registry that collects information from people with amyotrophic lateral sclerosis (ALS) to better understand the disease. Joining may help researchers learn about patterns of symptoms and care over time.
Atlanta, GeorgiaAges 18 years+ - NCT02567136Recruiting
Imaging study for people with ALS using MRI
This trial uses MRI scans to look for “imaging biomarkers” (scan patterns that may help track ALS). It may help researchers better understand disease changes over time and how ALS progresses.
Minneapolis, MinnesotaAges 21–75 - NCT02869048Recruiting
Study blood and immune signals in ALS and healthy controls
This trial studies the “innate immune system” (your body’s first-line immune response) in people with ALS and in comparison groups. It may help researchers understand what drives ALS and how immune changes could relate to symptoms.
AarhusAges 18 years+ - NCT03217396Recruiting
Study blood and MRI markers in people with multiple sclerosis
This study looks for signs of “synapse damage” in multiple sclerosis using blood tests and brain imaging (MRI). The goal is to find biomarkers that may help better understand MS and how it changes over time.
Pozzilli, IserniaAges 18–65 - NCT06051123Recruiting
Probiotics for ALS and related disorders
This trial tests whether probiotics (healthy bacteria) can help people with ALS. You'll take a probiotic or placebo daily for several months, and researchers will track your symptoms and gut health.
Fredericton, New BrunswickAges 18 years+ - NCT07401121RecruitingPhase 1
Study of CTx1000 for people with ALS
This trial tests a new drug, CTx1000, for people with ALS. It aims to see if the drug is safe and tolerable, and may offer a new treatment option.
Sydney, New South WalesAges 18–80 - NCT07414212RecruitingPhase 1/Phase 2
Testing EH-301 and NAC with Riluzole for ALS
This trial tests whether adding two supplements (EH-301 and N-acetylcysteine) to the standard ALS medicine Riluzole can help slow the disease. It is for people diagnosed with ALS within the last 18 months who still have good breathing and daily function.
San Sebastián, GuipuzcoaAges 18–75 - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT07491484Recruiting
Physical function and quality of life in ALS patients
This trial measures how physical function affects daily life and well-being in people with ALS. It aims to understand how movement abilities impact patient-reported outcomes.
Salisbury, MarylandAges 18 years+ - NCT07491562Recruiting
Testing a neck brace for ALS-related neck weakness
This study tests a special neck brace (exoskeleton) designed to help people with ALS who have neck weakness. It will see if the device helps support your head and makes daily tasks easier.
Salt Lake City, UtahAges Any age - NCT07502677Recruiting
Can a sleep test detect breathing trouble in ALS?
This study tests a new wearable device called SleepImage to see how well it detects breathing problems during sleep in people with ALS. The goal is to catch early signs of respiratory failure before they become serious, helping doctors decide when to start breathing support.
LondonAges 18 years+ - NCT07543367Recruiting
Brain implant to restore arm movement in ALS
This study tests a surgically implanted brain-computer interface (BCI)—a device that reads signals directly from your brain to help control a computer cursor or robotic arm. It's designed for people with ALS whose arms are paralyzed and who haven't responded to standard treatments.
Jacksonville, FloridaAges 22 years+ - NCT07660614RecruitingPhase 1/Phase 2
Testing a new drug for people with ALS
This trial studies an experimental drug called LTX-002 for people with ALS. It aims to see if the drug is safe and can slow down the disease.
LübeckAges 18–75 - NCT07539662Enrolling by invitation
Cord Blood Stem Cell Transplant for ALS
This trial tests whether a transplant of special cells from donated umbilical cord blood can help slow or improve symptoms of ALS (amyotrophic lateral sclerosis, also called Lou Gehrig's disease). The cells may help repair nerve damage and reduce disease progression.
TianjinAges 35–50
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Common questions
- Are there clinical trials for amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 189 recruiting amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.