Clinical trials
Primary Lateral Sclerosis clinical trials
Below are recruiting primary lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 24 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04363684Recruiting
Study of frontotemporal dementia and related syndromes over time
This study follows people with frontotemporal dementia (FTLD) and related conditions, and collects health and (for some people) body fluid information, to understand how these illnesses change over time. It may help researchers track disease signs and find better ways to measure progression.
Birmingham, AlabamaAges 18 years+ - NCT03489278Recruiting
Support procedures study for ALS using electronic health records
This study is about improving the research process for people with ALS by using electronic health records from participating clinics. If you have ALS and receive care at an Epic-using center, you may be asked to help with consent and study procedures.
Irvine, CaliforniaAges 18 years+ - NCT05204017Recruiting
Study platform to better understand and treat ALS
This study uses a comprehensive analysis platform to better understand ALS (and related conditions) and help find ways to “remedy and eliminate” it. If you have ALS or are a healthy control who can safely complete questionnaires and possibly an MRI, you may be able to contribute data that researchers use to improve care.
Edmonton, AlbertaAges 18 years+ - NCT07187388Recruiting
Electrical stimulation for jaw pain in motor neuron disease
This study tests whether gentle electrical stimulation around the jaw can ease facial pain, improve jaw movement, and help oral health in people with certain motor neuron diseases like ALS or PLS. It may be a good fit if you have jaw pain and meet a few health conditions.
Davie, FloridaAges 18 years+ - NCT07233148Recruiting
ALS, MND, or PLS registry study
This observational study creates a registry for people with ALS, MND, or PLS. It helps researchers better understand these conditions and find possible treatments.
Park City, UtahAges 18–110 - NCT02567136Recruiting
Imaging study for people with ALS using MRI
This trial uses MRI scans to look for “imaging biomarkers” (scan patterns that may help track ALS). It may help researchers better understand disease changes over time and how ALS progresses.
Minneapolis, MinnesotaAges 21–75 - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT07224269RecruitingEarly Phase 1
Terazosin for energy levels in ALS
This study tests whether a blood pressure medicine called terazosin can boost energy production in cells of people with ALS, potentially slowing the disease. It involves taking the medication daily for a period and monitoring safety and effects.
Iowa City, IowaAges 18–80 - NCT04008329Recruiting
Study of people with amyotrophic lateral sclerosis
This study follows people living with amyotrophic lateral sclerosis (ALS) over time. It may help researchers better understand ALS and track changes that could guide future treatments.
Fuzhou, FujianAges Any age - NCT07118319RecruitingPhase 1
Stem cell therapy safety trial for ALS
This trial tests a new treatment made from stem cells (called XS228CN) injected into the spine. It is primarily a safety study, but doctors will also watch for any signs the treatment may slow ALS progression.
Beijing, Beijing MunicipalityAges 18–75 - NCT06553976Recruiting
Research network for hereditary spastic paraplegia
This trial aims to build a research network and gather information from people with two genetic types of hereditary spastic paraplegia (SPG4 and SPG5A). It will help doctors better understand these conditions and improve care.
Miami, FloridaAges Any age - NCT03225144Recruiting
Study of gene and disease changes in ALS and frontotemporal dementia
This study looks at complex brain and body changes in people with ALS and frontotemporal dementia (FTD), or related disorders. If you have one of these diagnoses—or a known gene mutation that can cause ALS/FTD—you may be able to help researchers learn how the conditions progress.
Bethesda, MarylandAges 18–110 - NCT07726563Recruiting
Plasmapheresis for ALS with NRIP2 antibody
This trial tests whether a blood filtering treatment called plasmapheresis can help people with ALS who have a specific antibody (NRIP2) in their blood. It aims to see if removing this antibody can slow the disease and improve symptoms.
Taipei City, TaipeiAges 20 years+ - NCT07567664Enrolling by invitation
Brain Changes in Neurodegenerative Diseases: A Tracking Study
This research study tracks how brain damage progresses in rare neurodegenerative diseases like frontotemporal dementia, primary progressive aphasia, PSP, CBS, and ALS. Researchers use brain imaging and tests to understand how these diseases spread in the brain, which could help develop better treatments.
Milan, LombardyAges 20–85 - NCT04715399Recruiting
Research study collecting data for neurodegenerative diseases
This study collects health information from people with neurodegenerative diseases, some family members, and healthy controls to help researchers better understand these conditions. It may help future diagnosis and research, and participation may include noninvasive checks and other procedures depending on your situation.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06891716RecruitingEarly Phase 1
PET scan for TDP-43 proteinopathies
This study tests a new PET scan dye that may help see TDP-43 protein buildup in the brain, which is linked to certain dementias and ALS. It aims to improve diagnosis and tracking of these conditions.
AmsterdamAges 40–70 - NCT03567213Recruiting
CortiCom brain signal system for communication in severe paralysis
This trial tests a system that records brain signals to help people with severe paralysis and little or no speech communicate. It involves a surgical implant and frequent study visits to see if the system can work safely and reliably for communication.
Baltimore, MarylandAges 22–70 - NCT06578195Recruiting
Assess all ALS study
This study follows people with ALS and healthy volunteers over time to understand the disease better. You can join from home using a smartphone or computer.
Birmingham, AlabamaAges 18 years+ - NCT04302870RecruitingPhase 2/Phase 3
Test medicines for motor neurone disease using adaptive trial design
This study tests treatments for motor neurone disease (MND) and assigns people to different treatment arms in an adaptive way. It may help doctors find out which medicine works best and for whom.
Portadown, County ArmaghAges 18 years+ - NCT05632757Recruiting
Studying support for ALS patients and their family caregivers
This study looks at how much burden (stress and day-to-day strain) ALS creates for both the patient and the main caregiver. It may help shape better ways to support families facing ALS over time.
MarseilleAges 18 years+ - NCT07521930Recruiting
Brain implant to restore communication and movement control
This trial tests a surgically implanted brain device designed to help people with severe paralysis or movement disorders regain the ability to communicate and control their limbs. The device reads signals from your brain and translates them into commands that could help you interact with computers or assistive technology.
Baltimore, MarylandAges 18–80 - NCT06765499Recruiting
Silkworm pupa powder for nutrition and frailty in motor neuron disease
This trial tests whether silkworm pupa powder can improve nutrition and reduce frailty in people with motor neuron disease (like ALS). It looks for volunteers who are frail, have a confirmed diagnosis, and are willing to provide blood, stool, and urine samples.
Hangzhou, ZhejiangAges 18–80 - NCT06849609RecruitingEarly Phase 1
Gene therapy VGN-R13 for ALS safety and tolerability
This study tests a new gene therapy called VGN-R13 for people with ALS. It aims to see if the treatment is safe and tolerable, and if it can slow down the disease. You may be able to join if your ALS symptoms started recently and your lung function is still fairly good.
Wuhan, HubeiAges 18 years+ - NCT02795052Recruiting
Stem cell treatment trial for nerve injury
This study tests whether bone-marrow stem cells can improve nerve function in people with nerve damage that usually doesn’t recover with current care. It also checks whether the treatment is safe and whether people can be followed over time with repeated nerve exams.
Westport, ConnecticutAges 18 years+
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Common questions
- Are there clinical trials for primary lateral sclerosis?
- Yes. Clin2 currently lists 24 recruiting primary lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a primary lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a primary lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.