Clinical trials
ARDS (Moderate or Severe) clinical trials
Below are recruiting ards (moderate or severe) clinical trials, each written for real people, not researchers. We’re tracking 1,484 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05456893Recruiting
Testing blood and stool markers in active ulcerative colitis treatments
This study checks biomarkers (signals in blood and/or stool) in adults with moderate-to-severe ulcerative colitis. It compares patients starting targeted medicines and looks for marker patterns that may reflect how the disease is behaving.
Nancy, LorraineAges 18 years+ - NCT05529927RecruitingPhase 2
Dexamphetamine given long-acting to reduce cocaine use
This Phase 2 study tests whether a long-acting form of dexamphetamine can reduce cocaine use in people with moderate to severe cocaine use disorder. It also checks safety, including heart and mental health side effects, while you attend study visits regularly.
The HagueAges 18 years+ - NCT05539196Recruiting
Registry for Exablate treatment in Parkinson’s with medication problems
This trial is a real-world registry that follows people with Parkinson’s who are planning to get an Exablate 4000 procedure (a focused ultrasound treatment) for one-sided symptoms that are difficult to control with medication. It mainly checks outcomes and safety over time, helping doctors understand how well this treatment works in everyday care.
Baltimore, MarylandAges 30–99 - NCT05591924Recruiting
Bioinformatics study in adults with very early severe ICU illness
This trial studies how early severe illness in the ICU can be understood and tracked using health data (bioinformatics/informatics). It may help improve care decisions for people who arrive to the ICU soon after an emergency department visit.
London, OntarioAges 18 years+ - NCT05667090Recruiting
High-dose vitamin D3 to ease chronic pain in dialysis patients
This study tests whether taking a very high dose of vitamin D3 can reduce moderate to severe chronic pain in people on hemodialysis. It may help by improving vitamin D-related pathways that could affect pain, but you must also meet specific health and testing requirements.
TaipeiAges 20 years+ - NCT05732727RecruitingPhase 3
Stronger BP lowering using diuretics in kidney disease
This Phase 3 trial compares a plan that uses diuretics (water pills) to lower blood pressure more, versus usual blood pressure care, in people with uncontrolled hypertension and moderate-to-severe chronic kidney disease. It may help your blood pressure control while monitoring safety closely because kidney function changes how medicines work.
AngersAges 18 years+ - NCT05778188RecruitingPhase 2
RLS-0071 for newborns with moderate or severe HIE
This trial studies whether RLS-0071 is safe and can help some newborns with moderate or severe hypoxic-ischemic encephalopathy (HIE), a brain injury caused by low oxygen around birth. Babies in the study also receive standard whole-body cooling (therapeutic hypothermia), and the researchers will watch for side effects and early signs of benefit.
Little Rock, ArkansasAges Up to 10 hours - NCT05790239RecruitingPhase 2
MDMA therapy sessions for veterans with PTSD
This Phase 2 trial tests whether therapy assisted by MDMA can reduce symptoms of moderate to severe post-traumatic stress disorder (PTSD) in eligible veterans. It includes supervised therapy sessions and extra study visits with video recording to track changes over time.
Los Angeles, CaliforniaAges 18 years+ - NCT05819463Recruiting
Study care for moderate to severe atopic dermatitis
This trial looks at treatment and medical care for teens and adults with moderate to severe atopic dermatitis (eczema). It may help by testing ways to manage symptoms better based on severity and current treatment needs.
BaselAges 12 years+ - NCT05837897RecruitingPhase 3
Vedolizumab for adults with moderate-to-severe Crohn’s
This Phase 3 study tests whether vedolizumab can better control moderate-to-severe Crohn’s disease in adults whose symptoms haven’t improved enough with other treatments. You’d need to meet specific symptom scores, recent colonoscopy findings, and safety checks (including infections and vaccination status).
Hefei, AnhuiAges 18–80 - NCT05855252Recruiting
Study on monitoring and outcomes after moderate to severe head injury
This observational study follows adults with moderate to severe traumatic brain injury to understand care and outcomes. It collects information from the first 48 hours in the ICU and may help improve how clinicians monitor and treat patients in the critical early period.
Kogarah, New South WalesAges 18 years+ - NCT05896800Recruiting
Inhaled nitric oxide for moderate to severe COPD symptoms
This study tests whether inhaled nitric oxide gas can improve outcomes in people with moderate-to-severe chronic obstructive pulmonary disease (COPD). It may help reduce breathing problems by targeting how airways and blood vessels respond in the lungs.
Nanjing, JiangsuAges 40–75 - NCT05903352RecruitingPhase 3
Personalized antibiotic duration for hospital pneumonia patients
This trial compares how long antibiotics should be given to people hospitalized with moderately severe community-acquired pneumonia. It uses your early improvement to see which antibiotic duration works best and safely.
GarchesAges 18 years+ - NCT05923073RecruitingPhase 3
Guselkumab for children with active Crohn’s disease
This Phase 3 trial tests guselkumab to treat children with moderately to severely active Crohn’s disease and ongoing inflammation in the bowel. If you qualify, the study will check whether the medicine can improve symptoms and healing, especially in children who did not respond to other treatments.
Los Angeles, CaliforniaAges 2–17 - NCT05928039RecruitingPhase 4
Choosing the best first biologic for Crohn’s in the ileum
This Phase 4 trial tests which type of biologic medicine works best as the first treatment for people with moderate-to-severe Crohn’s that mainly affects the ileum. It may help you and your care team choose a more effective first option, based on which strategy leads to better control of symptoms and intestinal inflammation.
Calgary, AlbertaAges 18 years+ - NCT05995353RecruitingPhase 3
Risankizumab for children with moderate to severe Crohn's
This study tests a new medicine called risankizumab for children with moderate to severe Crohn's disease. It is given as an IV infusion or a shot under the skin to see if it can reduce inflammation and improve symptoms.
Phoenix, ArizonaAges 2–17 - NCT05995964RecruitingPhase 2
Study of two new medicines for eczema
This study tests two new study medicines (PF-07275315 and PF-07264660) for people with moderate to severe eczema that hasn't responded well to other treatments, including biologics. The goal is to see if these medicines can help reduce itching and clear the skin.
Birmingham, AlabamaAges 18 years+ - NCT06023030Recruiting
Observing how upadacitinib works for Crohn's disease in Japan
This study is for people with moderate to severe Crohn's disease who are starting a medication called upadacitinib. Researchers will watch how the disease changes over time and check for any side effects. It's an observational study, meaning you'll keep getting your regular treatment.
Anjo-shi, Aichi-kenAges 15 years+ - NCT06029972RecruitingPhase 2
Experimental drug for moderate to severe ulcerative colitis
This trial tests an experimental medication (tilpisertib fosmecarbil) for people with moderate to severe ulcerative colitis who have already tried at least one advanced therapy but it didn't work well enough. The study aims to see if this new drug can help reduce inflammation and improve symptoms.
Sun City, ArizonaAges 18–75 - NCT06030076Recruiting
Switching to tildrakizumab for moderate to severe psoriasis
This trial is for adults with moderate to severe plaque psoriasis who are currently on a biologic treatment (like Humira, Stelara, or Cosentyx) and are switching to tildrakizumab. It looks at how your quality of life and symptoms change after the switch.
Graz, StyriaAges 18 years+ - NCT06038071Recruiting
Family MUAC check-ups after recovery from malnutrition
This trial checks on children who have recovered from malnutrition to see how well they stay well. It uses a simple arm measurement to track their nutrition over time.
Sekota, AmharaAges 6 months–4.9 years - NCT06055361RecruitingPhase 1
Studying a new injection for moderate to severe eczema
This trial tests an investigational drug called BxC-I17e, given as an injection under the skin, for people with moderate to severe atopic dermatitis (eczema) that hasn't improved enough with standard creams. The goal is to see if it is safe and works well.
North Little Rock, ArkansasAges 18 years+ - NCT06062212Recruiting
Effects of lung pressure on recovery in severe ARDS on ECMO
This trial looks at how changes in lung pressure during breathing might affect recovery in patients with severe ARDS who are on a heart-lung bypass machine (ECMO). It could help doctors improve treatment for people with this serious lung condition.
Beijing, Beijing MunicipalityAges 18–75 - NCT06062888RecruitingPhase 2/Phase 3
Testing fresh frozen plasma for traumatic brain injury
This trial tests whether giving fresh frozen plasma (a blood product) soon after a traumatic brain injury can help people recover better. It is for adults aged 18 to 65 with moderate to severe TBI confirmed by CT scan.
Chicago, IllinoisAges 18–65
Hear when a new ARDS (Moderate or Severe) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for ards (moderate or severe)?
- Yes. Clin2 currently lists 1,484 recruiting ards (moderate or severe) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ards (moderate or severe) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ards (moderate or severe) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.