Clinical trials
Arthroplasty clinical trials
Below are recruiting arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 436 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06963320RecruitingPhase 2
Preventing blood clots after knee replacement with H001
This trial tests whether an experimental capsule (H001) can prevent dangerous blood clots after knee replacement surgery. It is for people who are scheduled for a first-time total knee replacement and are willing to take the study drug instead of standard blood thinners.
Shanghai, Shanghai MunicipalityAges 18–74 - NCT05863741Recruiting
Knee surgery planning using a 3D next-step guidance system
This trial studies whether a NextAR system’s planning and gait (walking) analysis can improve how knee replacement surgery is done and how you walk afterward. It’s for adults with severe knee osteoarthritis who are eligible for total knee replacement.
FremantleAges 18 years+ - NCT06956950RecruitingPhase 2/Phase 3
Magnesium Added to Numbing Medicine for Hip Replacement Pain
This study tests whether adding magnesium sulfate to a numbing medicine (bupivacaine) can provide better pain relief after hip replacement surgery. The medicine is given as a shot in the back near the hip muscles.
Tanta, El-GharbiaAges 18 years+ - NCT06943053Recruiting
Waterproof bandage study for knee replacement recovery
This study compares two types of waterproof bandages used after total knee replacement surgery to see which one works better at keeping the wound dry and clean.
Pathum Thani, Khlong luangAges 55 years+ - NCT06917365Recruiting
Testing a new liner for SERF hip replacements
This trial is testing a new liner (the inner part) for a specific brand of hip replacement called SERF. It's looking at how well it works in people who need a total hip replacement.
DijonAges 18 years+ - NCT07214311RecruitingPhase 2/Phase 3
A trial of PLG0206 to prevent knee joint infection after surgery
This trial tests if a new drug called PLG0206 can stop a knee joint infection from coming back after a surgery called DAIR. DAIR cleans the infected area and keeps the artificial knee in place, and this study wants to see if adding PLG0206 helps prevent the infection from returning.
Sarasota, FloridaAges 18–80 - NCT03839758Recruiting
Personalized implant study for shoulder arthritis
This study looks at a personalized implant/instrument setup for people having shoulder replacement due to wear-and-tear arthritis (and bone tissue death). It aims to see whether customizing the surgery approach improves outcomes over time, including up to 2 years.
Montreal, QuebecAges 18–99 - NCT06627699Recruiting
Study of the Freedom Total Knee System for knee replacement
This study is for people getting a total knee replacement for the first time. It looks at how well the Freedom Total Knee System works in everyday life.
Leawood, KansasAges 18 years+ - NCT06831045Recruiting
Bikini vs Straight Incision for Hip Replacement
This study compares two types of skin cuts (a bikini-line incision vs a straight side incision) for total hip replacement through the front of the hip. It is designed for people with a BMI of 30 or higher to see which incision heals better and leads to fewer wound problems.
Miami, FloridaAges 18 years+ - NCT06807866RecruitingPhase 4
Duloxetine for pain after hip replacement surgery
This trial tests if duloxetine, a medication that helps with nerve pain, can reduce pain after hip replacement surgery. It may help patients who are having a first-time total hip replacement.
Miami, FloridaAges 18 years+ - NCT05649007Recruiting
Monitoring the Saphir hip stem after new hip replacement
This study watches how a specific hip replacement part (the Saphir stem) performs after primary hip surgery in everyday care. It helps doctors and manufacturers learn about safety and outcomes after the device is already in use.
ToulouseAges 18 years+ - NCT07348614RecruitingPhase 4
Knee manipulation: best numbing method for less pain
This study tests different numbing techniques to see which works best for pain during a knee manipulation procedure. It may help you have less pain and a smoother recovery.
Durham, North CarolinaAges 18–75 - NCT06626490Recruiting
Follow-up study of the Prevision hip stem
This study follows patients who got a Prevision hip stem during revision hip surgery to see how well different versions of the stem perform. The goal is to help doctors choose the best options for you.
HanoverAges 18 years+ - NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+ - NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age - NCT06448325Recruiting
Hip replacement fracture risk prediction
This study looks at past hip replacement patients to develop a score that predicts who might have another fracture later. It may help doctors prevent future breaks.
Milan, ItaliaAges 60 years+ - NCT06323980Recruiting
Study of a new stemless shoulder replacement
This trial tests a new shoulder replacement system that does not require a stem (a long piece that goes into the arm bone). It is for patients with severe shoulder arthritis or rotator cuff problems. The study will see how well the device works and how it compares to other treatments.
Irvine, CaliforniaAges 22 years+ - NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT06576583RecruitingPhase 2
Cartilage graft for kneecap arthritis
This trial tests a new graft made from lab-grown cartilage to treat knee pain under the kneecap. It compares the graft to standard surgery for people with moderate-to-severe kneecap arthritis who haven't improved with other treatments.
ViennaAges 18–70 - NCT06896240Recruiting
Fiber smoothie trial for knee replacement patients
This trial tests if drinking a special fiber smoothie for 2 weeks before knee revision surgery can reduce inflammation and improve recovery. It is for people who are scheduled for knee replacement and have certain chronic health conditions.
New York, New YorkAges 40–80 - NCT06143306RecruitingPhase 4
Adding a second numbing shot for shoulder replacement pain
This study tests whether adding an extra numbing shot (pectoserratus block) to the standard shoulder block reduces pain after total shoulder replacement. It may help you recover more comfortably and use fewer pain medicines.
Minneapolis, MinnesotaAges 18–85 - NCT07587203Enrolling by invitation
Numbing medication for shoulder surgery and breathing
This trial compares two types of numbing medications (liposomal bupivacaine and standard bupivacaine) given as a nerve block for shoulder surgery. Researchers want to see which one works better for pain relief and causes fewer problems with your breathing afterward.
Nanjing, JiangsuAges 18–80 - NCT07506330Enrolling by invitation
Surgical environment and surgeon stress study
This study looks at how different surgical environments affect the stress levels of orthopaedic surgeons. It compares doing joint replacements the traditional way versus using a robot, to see which approach might be easier on the surgeon.
LondonAges 18–65 - NCT07481448Recruiting
Long-term study of complex hip replacements
This study follows patients who have had a complex hip replacement to see how they do over time. It may help if your hip surgery was more complicated than usual, such as after prior surgeries, injuries, or certain medical conditions.
Leuven, Vlaams-BrabantAges Any age
Hear when a new Arthroplasty trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for arthroplasty?
- Yes. Clin2 currently lists 436 recruiting arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.