Clinical trials
Arthroplasty clinical trials
Below are recruiting arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 450 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07362589Enrolling by invitation
Does pain education before knee or hip replacement help?
This study tests whether a special education session before knee or hip replacement surgery can help reduce anxiety, pain, and the need for pain medicine after surgery. If you are scheduled for joint replacement and can take part in a short learning session, you may be eligible.
Istanbul, KayişdağiAges 18 years+ - NCT07354542Recruiting
Relaxation therapy for pain and sleep after joint replacement
This trial tests if different relaxation methods, such as breathing exercises or virtual reality, can help reduce pain and improve sleep after hip or knee replacement surgery. It is designed for people who have had a joint replacement and are able to use a mobile phone or tablet.
Bartın, CenterAges 18 years+ - NCT05111405Recruiting
Compare two surgeries for thumb CMC arthritis
This trial compares two different operations for thumb CMC (carpometacarpal) arthritis. It looks at which surgery works better when other non-surgery treatments have not helped you.
Calgary, AlbertaAges 50 years+ - NCT07350252RecruitingPhase 4
Nerve blocks with local pain relief for knee replacement
This study tests if adding a nerve block to standard local pain relief medicine helps control pain better after knee replacement surgery. It may lead to less pain and faster recovery.
TrelleborgAges 18 years+ - NCT07348614RecruitingPhase 4
Knee manipulation: best numbing method for less pain
This study tests different numbing techniques to see which works best for pain during a knee manipulation procedure. It may help you have less pain and a smoother recovery.
Durham, North CarolinaAges 18–75 - NCT07309796Recruiting
Strengthening exercises after reverse shoulder replacement
This study tests whether specific strengthening exercises for the shoulder muscles that help lift your arm can improve recovery after a reverse total shoulder replacement. You will be randomly assigned to receive these exercises or standard care, and your progress will be tracked.
KırşehirAges 65–90 - NCT06877936Recruiting
Shoulder replacement imaging study
This study uses a special low-dose X-ray machine (EOS®) to take 3D pictures of your shoulder after reverse total shoulder replacement. The goal is to better understand how the replacement parts move and fit together. It may help improve future surgeries.
LyonAges 18 years+ - NCT07288970Recruiting
Comparing two numbing injections for knee replacement pain
This study compares two types of numbing injections (nerve blocks) to see which provides better pain relief after total knee replacement surgery. If you are 65 or older and having your first knee replacement, you may be able to join.
PoznanAges 65–100 - NCT07286513Enrolling by invitation
Study of a new knee replacement implant
This study follows patients who receive a specific type of knee replacement implant called the Persona® SoluTion® PPS, to see how well it works over time. If your surgeon recommends this implant and you meet standard health requirements, you may be able to join.
Denver, ColoradoAges 18 years+ - NCT07284615Recruiting
Nerve Block vs. Wound Injection for Hip Replacement Pain
This trial compares two pain-relief methods after hip replacement surgery: a nerve block (numbing the hip area) versus a numbing injection into the wound. The goal is to see which provides better pain control.
Cinisello Balsamo, MilanoAges 18 years+ - NCT07282561Recruiting
Nutrition and virtual rehab for older adults with shoulder issues
This study tests whether a virtual reality shoulder exercise program combined with nutritional support helps older adults recover better after surgery. It focuses on people who are frail and have shoulder problems needing surgery.
RomeAges 60 years+ - NCT07282782RecruitingPhase 4
Vancomycin for knee replacement surgery
This trial is testing the antibiotic vancomycin to prevent infections after total knee replacement. It may help if you are having your first knee replacement and are not severely overweight or diabetic.
San Diego, CaliforniaAges 18 years+ - NCT06888908Recruiting
Blood volume changes during hip replacement surgery
This trial measures how blood volume and fluids shift in the body during and after hip replacement surgery. It helps doctors better understand fluid management for patients having this procedure.
CopenhagenAges 18 years+ - NCT07271849RecruitingPhase 4
Timing of Nalbuphine for Pain and Blood Pressure in Older Knee Surgery Patients
This study tests whether giving the pain medicine nalbuphine at different times during knee replacement surgery affects blood pressure and pain control in older adults. It may help find the best timing to reduce pain and keep vital signs stable.
Jinan, ShandongAges 65–90 - NCT04468178Recruiting
Testing a new shoulder implant and checking its position over time
This study looks at how well a specific shoulder replacement implant works for people with worn-out (arthritic) shoulder joints. It also checks how well the implant stays in the right position as you heal after surgery.
Hanover, Lower SaxonyAges 18–80 - NCT06758297Recruiting
AI motivational talk after knee replacement
This study tests whether an artificial intelligence-guided motivational conversation can help reduce fear of moving after knee replacement surgery, and improve how much you can move.
Samsun, SamsunAges 18 years+ - NCT06899932Recruiting
Genutech knee replacement survival study
This study tracks how long Genutech knee replacements last in people with knee arthritis. It is for adults whose arthritis did not improve with non-surgical treatments like physical therapy or medication.
Barcelona, BarcelonaAges 18 years+ - NCT05030220Recruiting
Testing testosterone and a skin bacteria during shoulder surgery
This study looks at how testosterone levels and a common skin bacteria (Cutibacterium) may relate to outcomes around elective shoulder replacement surgery. Results could help improve how doctors prevent and understand infection risk or healing after surgery.
Seattle, WashingtonAges 18–89 - NCT07239817Recruiting
Nerve block and local anesthetic for hip replacement surgery
This study tests whether a nerve block plus local anesthetic can improve pain control during and after hip replacement surgery for a broken hip. It may help reduce the need for stronger pain medications and improve recovery.
MilanAges 18 years+ - NCT07227064RecruitingPhase 3
Methadone for pain relief after hip replacement surgery
This study tests whether a single dose of methadone given during hip replacement surgery can better control pain and reduce the need for other opioid painkillers afterward. It may help you recover with less pain and fewer side effects.
Charleston, South CarolinaAges 18–75 - NCT07225751Recruiting
MagnetOs Bone Graft vs. Your Own Bone for Foot Fusion
This study tests a new bone graft material (MagnetOs) against using your own bone for hindfoot or ankle fusion surgery. The goal is to see if the new material works just as well for helping bones heal together.
Sacramento, CaliforniaAges 18–75 - NCT05206838Recruiting
Treating gluteus medius tendon weakness after hip replacement
This trial looks at treating a specific hip muscle-tendon problem (gluteus medius insufficiency) after total hip replacement. It may help people who have had ongoing limping despite surgery by using an Achilles tendon–based approach.
MölndalAges 40–80 - NCT07214311RecruitingPhase 2/Phase 3
Preventing repeat knee infection after joint-saving surgery
This trial tests a new medicine called PLG0206 to help prevent a knee infection from coming back after a procedure to clean the joint while keeping the artificial knee in place. If you qualify, you'll receive the study medicine or a placebo along with standard antibiotics.
Sarasota, FloridaAges 18–85 - NCT07213778RecruitingPhase 3
Comparing a new drug to aspirin for blood clot prevention after knee replacement
This trial tests a new medicine called REGN7508 against aspirin to prevent blood clots after total knee replacement surgery. It may help if you are having a planned knee replacement and are in good health.
La Mesa, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for arthroplasty?
- Yes. Clin2 currently lists 450 recruiting arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.