Autoimmune Diabetes clinical trials

Tool to help decide diagnosis and treatment in immune disorders

This trial tests a tool (a way of collecting health information) to help doctors make better diagnosis, prognosis, and treatment decisions for children with certain immune problems. It also includes healthy children (like relatives) as comparison groups, to see how well the tool works.

Real-world test of automated insulin delivery in primary care

This study tests if an automated insulin delivery system (the iLet bionic pancreas) works well in real-world primary care settings for people with type 1 or type 2 diabetes. It aims to see if this technology can help manage blood sugar more easily.

Comparing oxidative stress in type 1 diabetes and LADA

This study looks at oxidative stress—a type of cell damage—in people with type 1 diabetes or LADA. It may help explain how these conditions affect the body and guide future care.

Coping skills program for type 1 diabetes distress

This study tests a program to help adults with type 1 diabetes who feel stressed or overwhelmed by their condition. You'll join virtual group sessions to learn coping skills and track how your distress changes over time.

Study linking diabetes genes to better care

This trial is studying people with certain types of diabetes, including diabetes that starts after age 30 or in pregnancy, to help improve clinical care. You may be invited if your diabetes type fits the study’s genetic and antibody criteria.

Type 1 Diabetes and Blood Vessel Health Study

This study looks at how blood vessels and nerves work in people with Type 1 diabetes compared to healthy volunteers. It may help explain how diabetes affects heart and blood vessel health.

Building exercise habits for type 1 diabetes

This study helps adults with type 1 diabetes who don't exercise much build a safe and lasting exercise routine. You'll learn how to start moving more while managing your insulin and blood sugar levels.

Vaccine to prevent type 1 diabetes in high-risk babies

This study tests whether a vaccine given to very young babies (3–4 months old) can prevent type 1 diabetes. It is designed for babies who have a high genetic risk and a family history of the disease.

Diet and activity counseling for infants at risk for type 1 diabetes

This study tests whether a program of diet and activity advice for families can lower the risk of type 1 diabetes in infants who have a higher genetic chance of developing it. It aims to find simple, everyday ways to help protect your child.

Study family genetics in type 1 diabetes

This study looks at genetic patterns in families where someone has type 1 diabetes (an autoimmune condition). It may help researchers understand why type 1 diabetes happens and who is at risk.

Insulin delivery and eating behaviors in type 1 diabetes

This study looks at how different insulin delivery methods (like injections or pumps) affect eating behaviors in people with type 1 diabetes. By joining, you may help researchers learn how to improve care and quality of life.

Antibiotics to prevent infection after hip or knee replacement

This trial studies whether giving antibiotics before and/or after surgery can lower the chance of a serious joint infection after elective hip or knee replacement. It’s aimed at people at higher risk for infection.

Automated insulin system for LADA diabetes

This trial tests a hybrid closed-loop insulin pump system for people with LADA (a slow-progressing form of autoimmune diabetes). It aims to see if the system can improve blood sugar control and reduce hypoglycemia.

Study of immune changes in people with type 1 diabetes and other diabetes

This study looks at immune (defense system) and blood-sugar changes in people with type 1 diabetes, and in some other diabetes or autoimmune hormone conditions. It includes people who will have a specific abdominal surgery so doctors can safely study lymph node tissue.

Study kidney samples to understand autoimmune, inflammatory, and diabetic disease

This trial collects and studies kidney tissue samples to better understand what drives kidney problems linked to autoimmune, inflammation, and diabetes. Your participation may help researchers develop better ways to diagnose and treat these conditions.

Study to improve blood sugar and reduce inflammation

This study looks at how an intervention may improve blood sugar control and lower inflammation in the body. You may be able to take part unless you have a specific condition called celiac disease.

Study of stem cells for several short- and long-term illnesses

This early-stage study tests whether injections of mesenchymal stem cells can be safe and helpful for certain chronic (long-term) and acute (short-term) conditions. You might be considered if you can consent, are able to return for follow-up visits, and do not have key reasons that would make stem-cell treatment unsafe.

Metabolic study to improve insulin sensitivity in type 1 diabetes

This study tests a new medication to see if it can improve how your body responds to insulin and boost your cells' energy (mitochondrial function). It is for adults with type 1 diabetes who are already on insulin and have good overall health.

Support program for adults with type 1 diabetes

This trial tests an online support platform to help adults with type 1 diabetes manage their condition. If you live in Canada, have internet access, and can read English or French, you may be able to join.

A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

Online training for teens with type 1 diabetes moving to adult care

This trial tests an online training program to help teens with type 1 diabetes make the transition from pediatric care to adult care. It may help you feel more prepared for changes in how diabetes is managed as you get older.

Music therapy over video for depression and hormone disorder

This trial tests if telehealth music therapy can help adults who have both an endocrine autoimmune disease and depression. You'll join sessions from home using Zoom.

Glucose monitoring for young adults at risk of DKA

This study tests a real-time glucose monitor (RT-CGM) to help young adults with insulin-treated diabetes recognize dangerously high or fast-changing blood sugars. It may help lower the risk of diabetic ketoacidosis (DKA), a serious complication that can lead to urgent care or hospital stays.

Rituximab plus cyclosporine for membranous kidney disease

This trial tests whether rituximab (an immune-targeting medicine) plus cyclosporine (another immune medicine) can better control protein leakage in the urine for people with idiopathic membranous nephropathy. It may help reduce long-lasting kidney damage risk when standard treatments like ACE inhibitor or ARB don’t control the protein level.