Clinical trials
Biologics clinical trials
Below are recruiting biologics clinical trials, each written for real people, not researchers. We’re tracking 622 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04690972Recruiting
Collection of blood and tissue samples for liver disease research
This study builds a research library of biological samples (like tissue and blood) from people with chronic liver disease. It aims to create better lab and preclinical models of tumors and long-term liver problems, which may help future treatments.
StrasbourgAges 18 years+ - NCT04706481Recruiting
Use of stored, de-identified samples for research
This trial is for people who already agreed to let researchers use their stored biological samples and medical information that has been removed of personal identifiers. It may help future studies by allowing researchers to analyze existing samples without using new samples from you.
Hong KongAges Any age - NCT04692493RecruitingPhase 3
Testing two treatment paths for active rheumatoid arthritis
This Phase 3 study compares two ways to treat active rheumatoid arthritis: a TNF-blocking biologic versus a targeted pill treatment. It may help people who are not doing well on (or cannot tolerate) certain biologic therapies to find a better, more practical option.
Auburn, AlabamaAges 18 years+ - NCT04698421Recruiting
Blood and tissue sample collection for rare autoimmune nerve diseases
This study collects biological samples (like blood or other specimens) from people with rare neurological conditions that may involve the immune system. Your samples may help researchers better understand these diseases.
ToulouseAges 6–99 - NCT04650568Enrolling by invitation
Stem cell treatment after ACL ligament surgery
This trial studies whether adding mesenchymal stem cells during ACL (knee ligament) reconstruction helps the knee heal better. You might be eligible if your ACL injury is recent and you’re having a specific type of graft surgery.
Chicago, IllinoisAges 18–60 - NCT04621357Recruiting
Testing how brain swelling affects recovery after brain bleeding
This study looks at brain swelling (“cerebral edema”) after a spontaneous brain bleed and how it relates to outcomes. It mainly involves people who can have early care and MRI scans, to better understand what affects recovery.
LilleAges 18 years+ - NCT04509050Recruiting
Testing a highly effective CF medicine in young children
This study looks at how well a highly effective cystic fibrosis (CF) medicine works in infants and young children, and what biological changes it causes. It may help families understand whether the medicine improves CF function and related measures early in life.
Birmingham, AlabamaAges Up to 10 years - NCT04396899RecruitingPhase 1/Phase 2
Stem cell heart patch for advanced heart failure
This early-phase study tests a lab-made heart tissue (“engineered myocardium”) placed surgically to help the heart work better in people with advanced heart failure. It mainly checks safety first, and also looks for signs the patch can improve heart function in selected patients.
Göttingen, Lower SaxonyAges 18–80 - NCT04476563Recruiting
Study liver injury from checkpoint cancer immunotherapy
This study looks at why some people develop liver inflammation after checkpoint inhibitor cancer treatment, called checkpoint inhibitor–induced liver injury (ChILI). It compares people with ChILI to similar cancer patients who are starting the same type of immunotherapy, to better understand and track these liver injury events.
NottinghamAges 18 years+ - NCT04442100Recruiting
Testing a new easy-change heart valve replacement system
This study tests a biological (tissue) heart valve replacement system designed to be easier to change later. It may help people who need valve surgery because their valve is narrowed or damaged.
Tomsk, Tomsk OblastAges 60 years+ - NCT04297085Recruiting
Study of why blood clots in veins come back
This study follows people who have had a vein blood clot (or related venous clot) to understand what factors may make the clot happen again. It may help clinicians find better ways to prevent repeat clots.
BrestAges Any age - NCT04207814Recruiting
Studying causes of repeated pregnancy loss in otherwise unexplained cases
This study looks for possible reasons why some pregnancies end in miscarriage or stillbirth when no clear cause is found. It involves tests and information from both partners, which may help guide future care for couples like yours.
BrestAges 18–40 - NCT04174066Recruiting
Study on kidney damage in children and adults with MGLS or FSGS
This trial collects medical data and blood/urine samples from patients with minimal change disease or focal segmental glomerulosclerosis (FSGS) to better understand how the immune system damages kidney cells.
NiceAges 1 year+ - NCT04159675Recruiting
Burosumab and vitamin D for kids needing skull surgery
This study tests whether burosumab and vitamin D affect bone cells before and around the time of craniosynostosis surgery in children. It may help researchers understand treatment options for rare calcium and phosphate bone disorders that can affect skull growth.
BronAges 4 months–18 years - NCT03268668Recruiting
Study brain clot makeup and blood markers after stroke
This study looks at the composition of a stroke blood clot and compares it with blood test results to understand treatment response, stroke cause, and prognosis. It may help doctors better predict outcomes and improve care after ischemic stroke.
BordeauxAges 18 years+ - NCT03237702Recruiting
Study uses urine tests to understand prostate cancer
This study collects a small urine sample around the time of a prostate biopsy to look for chemical “signals” that may explain dangerous prostate cancer behavior. Your results are not shared with you, but the information may help researchers improve understanding and future care.
TaipeiAges 30–100 - NCT04115267Recruiting
Registry study tracking side effects from radiation and medicines
This study follows people with cancer to better understand which treatments cause certain side effects when radiation is combined with targeted (molecular) medicines. Your participation may help doctors predict and manage side effects more safely in the future.
Montreal, QuebecAges 18 years+ - NCT04014348Recruiting
Study links neighborhood stress to heart health in women
This study looks at whether stressful neighborhood conditions are connected to heart-health blood markers and everyday health behaviors. It mainly enrolls healthy women in Washington, DC to help researchers understand how environment may affect cardiovascular risk.
Bethesda, MarylandAges 19–45 - NCT04011982Recruiting
Study of tissue analysis after pancreatic cancer surgery
This trial studies and analyzes tissue samples from people who had surgery for exocrine pancreatic (pancreatic duct-type) cancer. It may help researchers better understand the disease biology and improve future care.
LyonAges 18 years+ - NCT04018118Recruiting
Study of the course of high eosinophil blood disease
This study follows people with long-term high eosinophils (a type of white blood cell) and related conditions to learn how the illness changes over time. It helps doctors understand patterns of organ involvement and outcomes, which may improve future care.
LilleAges Any age - NCT03967600Recruiting
Study of hidradenitis suppurativa skin features
This study looks at the physical and biological (body-related) characteristics of hidradenitis suppurativa. It may help researchers understand the condition better and improve future care.
San Francisco, CaliforniaAges 13 years+ - NCT03943316Recruiting
Testing new cancer treatments on cells from ovarian cancer fluid
This laboratory study uses ovarian cancer fluid collected during surgery to test possible new treatments on cancer and immune cells. It may help researchers find better treatment options in ovarian cancer.
Albuquerque, New MexicoAges 18 years+ - NCT03968913RecruitingEarly Phase 1
Biologic shot to prevent knee arthritis after ACL injury
This early-phase trial tests a biologic medicine (anakinra) given after an ACL injury to try to prevent or reduce later osteoarthritis (wear-and-tear arthritis). It enrolls young adults who recently tore their ACL and are planning a specific type of ACL reconstruction.
Los Angeles, CaliforniaAges 18–35 - NCT03610906Enrolling by invitation
Study of blood/tissue targets in suspected childhood brain tumors
This study looks at biological “targets” (things in the body) to help guide future medical treatments for children and teens with suspected craniopharyngioma. It will collect and analyze tissue samples from planned care to understand what therapies might work best.
Aurora, ColoradoAges 4 weeks–21 years
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Common questions
- Are there clinical trials for biologics?
- Yes. Clin2 currently lists 622 recruiting biologics studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a biologics trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a biologics trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.