Clinical trials
Bipolar II Disorder clinical trials
Below are recruiting bipolar ii disorder clinical trials, each written for real people, not researchers. We’re tracking 63 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06920940Recruiting
Ketogenic diet for bipolar disorder in teens
This study tests whether a ketogenic diet (a very low-carb, high-fat diet) can help teens with bipolar disorder who are currently feeling depressed or have mixed symptoms. Participants will receive medical and dietitian support while trying the diet for up to 12 weeks.
Los Angeles, CaliforniaAges 12–21 - NCT07127913Recruiting
Closed-loop brain stimulation for hard-to-treat bipolar depression
This trial tests a closed-loop deep brain stimulation system for people with bipolar II disorder whose depression has not responded to standard treatments. The device sends targeted electrical pulses to the brain based on real-time activity, aiming to reduce depression symptoms.
San Francisco, CaliforniaAges 22–70 - NCT07172516RecruitingPhase 3
Study of azetukalner vs placebo for bipolar depression
This trial tests whether the study drug azetukalner can help reduce depression symptoms in people with bipolar I or II disorder who are currently having a depressive episode. You would be randomly assigned to receive either the drug or a placebo (inactive pill) to see which works better.
Tucson, ArizonaAges 18–74 - NCT07211217Recruiting
Time-restricted eating for bipolar depression
This study tests if eating only during a specific daily window can help with weight loss and mood in people with bipolar disorder who are currently depressed and overweight.
Boston, MassachusettsAges 18–65 - NCT07213466RecruitingPhase 4
Personalized weight-loss medication for bipolar disorder
This study wants to see if a personalized approach with FDA-approved weight-loss medications can help people with bipolar disorder who are overweight or have obesity, while staying on their mood stabilizer treatment. It might be a good fit if you have bipolar disorder and struggle with your weight.
Rochester, MinnesotaAges 18–65 - NCT07221864Recruiting
Emotions and brain activity in bipolar disorder
This study uses brain scans to understand emotions in bipolar disorder. It compares people with bipolar who are currently depressed or in a mixed state to healthy volunteers, and involves up to two visits to the research center.
Tulsa, OklahomaAges 18–65 - NCT07286175RecruitingPhase 2
Study of brenipatide for bipolar disorder
This trial tests an experimental drug called brenipatide for people with bipolar I or II disorder. It aims to see if the drug can help manage mood episodes when added to your current stable medications.
Orange, CaliforniaAges 18–75 - NCT07679204Recruiting
Personality and life satisfaction in bipolar and depression
This study looks at how personality traits and life satisfaction affect people with bipolar II disorder or major depression. You will fill out questionnaires about your feelings and daily life.
ElâzığAges 18 years+ - NCT07412132RecruitingPhase 3
Testing lacosamide for hard-to-treat bipolar depression
This study tests if a medication called lacosamide can help people with bipolar depression that has not improved with at least two other treatments. It's for those with moderate to severe depression in bipolar I or II.
São Paulo, São PauloAges 18–65 - NCT07622927Recruiting
Family conversations about bipolar disorder risk in youth
This study helps families talk about bipolar disorder when a parent or caregiver has it. Researchers are creating and testing a new tool to help young people understand their risk and recognize early warning signs, with the goal of getting help sooner if needed.
Dallas, TexasAges 7 years+ - NCT07217860Enrolling by invitationPhase 3
Long-term safety study of azetukalner for bipolar depression
This study is looking at the long-term safety of azetukalner for people with bipolar I or II depression who have already completed a previous trial of this drug. It is an open-label study, meaning everyone will receive the active medication.
Little Rock, ArkansasAges 18–75 - NCT07151846Enrolling by invitation
Using phone data to predict depression
This study uses your smartphone and a Fitbit to track mood patterns and see if they can predict depression. You may join as someone with a mood disorder, as a healthy volunteer, or as someone at higher risk for mood problems.
Seoul, Seongbuk-guAges 19–75 - NCT07437833Recruiting
Self-regulation exercises for women with ADHD and stable bipolar disorder
This study tests how six different self-regulation techniques affect your body and brain during one session. It's designed for women with both ADHD and stabilized bipolar disorder who have been off psychiatric medications for at least two years.
PoznanAges 18–35 - NCT06560749Recruiting
Exercise to help thinking in bipolar disorder
This study tests whether a regular exercise program can help improve thinking and memory problems that often come with bipolar disorder. You must have stable mood and no recent changes to your medications.
São Paulo, São PauloAges 18–60 - NCT05153369Recruiting
DBT-based care for youth at risk for bipolar disorder
This study tests a structured, “DBT-informed” care program for young people who either have bipolar disorder or are at family risk for it. It may help by offering closer, organized support aimed at preventing or reducing mood problems.
Toronto, OntarioAges 13–23 - NCT06081426Recruiting
Ketogenic diet for bipolar disorder brain study
This study looks at how a ketogenic diet (very low carb, high fat) might affect brain function in people with bipolar disorder. Participants will follow the diet and have brain scans and blood tests to see how it helps mood and energy levels.
Pittsburgh, PennsylvaniaAges 18–40 - NCT07540338RecruitingPhase 1/Phase 2
New Lithium Capsule Study for Bipolar I
This study compares a new lithium capsule (AL001) to a standard lithium capsule in people with Bipolar I Disorder. It aims to see how well your body absorbs each capsule and whether AL001 is safer or more tolerable.
Boston, MassachusettsAges 18–65 - NCT02242110Recruiting
Brief treatment to reduce trauma nightmares in bipolar adults
This trial tests a short therapy to help adults who have frequent trauma-related nightmares. It focuses on people with bipolar disorder whose nightmares have been happening regularly for at least a month.
Tulsa, OklahomaAges 18 years+ - NCT06951698RecruitingPhase 3
Testing KarXT for bipolar I mania
This trial tests a new medicine, KarXT, to see if it can safely treat manic episodes in people with bipolar I disorder. It is for patients who are currently hospitalized for a manic episode that started within the last 3 weeks.
Bentonville, ArkansasAges 18–65 - NCT06929273RecruitingPhase 3
Long-term safety study of KarXT for bipolar I mania
This study tests the long-term safety of KarXT for people with bipolar I disorder who are having a manic or mixed episode. It is for people who either completed a previous KarXT study or are new to the study and have moderate to severe mania symptoms.
Glendale, ArizonaAges 18–65 - NCT06951711RecruitingPhase 3
KarXT for mania in bipolar I disorder
This study tests a new medication called KarXT to see if it helps calm manic episodes in people with bipolar I disorder. You would need to be in the hospital for a manic episode and stop other psychiatric medications temporarily.
Little Rock, ArkansasAges 18–65 - NCT06555406Recruiting
Healthy lifestyle study for bipolar disorder with sleep issues
This study tests a healthy lifestyle program for people with bipolar disorder who have sleep or schedule problems. It aims to see if changing daily habits can help improve mood and sleep.
Berkeley, CaliforniaAges 18–65 - NCT06729541Recruiting
Precision treatments for common mental disorders
This study is developing more personalized treatments for schizophrenia, depression, or bipolar disorder. It may help find the best treatment approach for your specific situation.
Beijing, Beijing MunicipalityAges 18–65 - NCT06134349Recruiting
Bipolar Lithium Imaging Scan Study
This study uses MRI scans to look at how lithium affects the brain in people with bipolar disorder. It may help researchers understand why lithium works and how to use it better.
Leiden, South HollandAges 18 years+
Hear when a new Bipolar II Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for bipolar ii disorder?
- Yes. Clin2 currently lists 63 recruiting bipolar ii disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar ii disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar ii disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.