Clinical trials
Brain Diseases clinical trials
Below are recruiting brain diseases clinical trials, each written for real people, not researchers. We’re tracking 328 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07417280Recruiting
Focused ultrasound for neurological disorders
This trial tests a gentle ultrasound treatment (LIFUS) for people with various brain conditions like epilepsy, tumours, or movement disorders. It aims to see if this non-invasive approach can help where other treatments are being used.
Toronto, OntarioAges 18–85 - NCT06683378RecruitingPhase 1
Parkinson's study: nerve implant during DBS surgery
This trial tests if implanting a small piece of your own leg nerve into the brain can improve Parkinson's symptoms. It is done at the same time as deep brain stimulation (DBS) surgery.
Lexington, KentuckyAges 45–75 - NCT07299240Recruiting
Arm cuff exercise for better sleep in Parkinson's
This trial tests if a simple, non-invasive arm cuff treatment can improve sleep and other non-motor symptoms in people with early Parkinson's disease. It involves using a blood pressure-like cuff on your arm to briefly restrict blood flow, then release it, hoping to train your body's protective systems.
Nanjing, JiangsuAges 50–70 - NCT05907317RecruitingPhase 3
Protecting the brains of very young newborns on breathing machines
This Phase 3 study tests ways to protect brain health in newborns who are very premature or recently born and need a breathing machine through a tube. It may help reduce the risk of brain injury while they receive intensive care.
MadridAges birth–4 weeks - NCT05661084Recruiting
Non-surgery brain stimulation for dementia thinking and movement
This study tests whether a non-invasive brain stimulation device (tES) can improve thinking and movement problems in people with dementia. You (and your caregiver, if needed) will be asked to follow the study plan and attend visits so researchers can measure results and safety.
Boston, MassachusettsAges 55 years+ - NCT05085704Recruiting
Brain scans to study metabolism in healthy and diabetic people
This study uses MRI brain scans at different strengths to measure how the brain uses energy (metabolism) in health and in people with genetically confirmed G1D. It may help researchers understand brain energy changes related to metabolic disease and diabetes.
New York, New YorkAges 16–80 - NCT07636304Enrolling by invitationEarly Phase 1
Brain stimulation for inflammatory bowel disease remission
This study tests whether a non-invasive device that stimulates the vagus nerve (a major nerve in your neck) can affect brain function in people whose IBD is in remission. Researchers want to understand if this stimulation might help reduce inflammation or improve symptoms in the future.
Gdansk, Pomeranian VoivodeshipAges 18 years+ - NCT07323121Recruiting
Flickering light therapy for sleep problems in Parkinson's
This study tests whether a special flickering light (40 Hz) can help improve sleep in people with Parkinson's disease. Participants will be exposed to the light at home, and researchers will track changes in sleep quality.
Nanjing, JiangsuAges 50–75 - NCT03020381Recruiting
Study of walking patterns to predict dementia and falls
This study looks at how your walking (gait) might help predict future dementia and risk of falls. You may be asked to walk tests and have health information collected to see who is at higher risk.
London, OntarioAges 60–85 - NCT07752784RecruitingPhase 3
Tau brain imaging in people with mild thinking changes or Alzheimer's
This study uses a special PET scan to take pictures of abnormal tau protein in the brain. It aims to see if the scan results match what is found in brain tissue after death, which could help improve diagnosis of Alzheimer's and related conditions.
Beijing, Beijing MunicipalityAges 50 years+ - NCT07595666Enrolling by invitation
New PET scanner versus standard PET for head and neck imaging
This study compares a newer PET/CT scanner (called NeuroEXPLORER) with standard PET/CT scanners for imaging the head and neck region. The goal is to see if the new scanner provides better or clearer images to help diagnose conditions.
Leuven, Vlaams-BrabantAges 4 weeks+ - NCT07096336Recruiting
Vitamin D3 and brain waves in Parkinson's study
This study tests whether taking vitamin D3 can improve brain wave patterns in men with Parkinson's disease who have low vitamin D levels. It may help understand if vitamin D supports brain health.
Dhaka, ShahbagAges 51–70 - NCT06875765Recruiting
Long-term brain imaging study for Parkinson's patients
This study uses brain scans to look at nerve endings in people with Parkinson's disease over time. It may help researchers understand how the disease progresses.
LeuvenAges 30 years+ - NCT07521384Enrolling by invitation
Real-World Study of Intranasal Cell Therapy for Brain Injuries
This study follows people who receive intranasal stem cell or exosome therapy (tiny packages from special cells) for brain or neurological conditions like stroke, brain injury, or cerebral palsy. Researchers track how well the treatment works by measuring inflammation markers in the blood and monitoring clinical improvements over time.
Monterrey, Nuevo LeónAges 4–80 - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT07496918RecruitingPhase 2
Brain effects of light and sound stimulation at 40 Hz
This study tests whether special lights and sounds (at a specific 'gamma' frequency) can safely affect brain activity. It is an early trial looking at how the brain responds to these gentle sensory stimulations.
Cambridge, MassachusettsAges 18–100 - NCT07041450Recruiting
Screening for Alzheimer's treatment using digital tests and blood tests
This study is testing whether simple digital memory tests and blood tests can help find people who might qualify for anti-amyloid treatments (medications that target Alzheimer's-related proteins). It aims to make screening easier and faster, without needing a spinal tap or PET scan.
Greenfield Park, QuebecAges 55–90 - NCT05697159Recruiting
7-tesla brain MRI to study how filgotinib eases RA pain
This trial uses a very high-strength brain MRI to understand how the RA medicine filgotinib may reduce pain. If you have active rheumatoid arthritis and can safely complete the scan, the study may help researchers better target pain relief in RA.
GlasgowAges 18–74 - NCT06669546Recruiting
Quiet sounds during deep sleep for memory in older adults
This study tests whether playing a soft, silent sound (or no sound) during deep sleep can improve memory, brain activity, and blood markers. It is for older adults (60-85) who have mild memory issues but are otherwise healthy.
BernAges 60–85 - NCT07673770Recruiting
Brain stimulation to improve memory in dementia
This study tests whether a safe, non-invasive brain stimulation technique called TMS (transcranial magnetic stimulation) can help improve memory and thinking in people with dementia. By measuring your brain waves first, researchers hope to tailor the stimulation to your specific needs.
Hamilton, OntarioAges 55 years+ - NCT06016387RecruitingPhase 2
Drug combo with radiation for HER2+ breast cancer spread to spinal lining
This trial tests a combination of three targeted drugs (tucatinib, trastuzumab, and capecitabine) along with radiation to the brain or spine for people whose HER2-positive breast cancer has spread to the lining of the brain or spinal cord. The goal is to see if this treatment is safe and effective.
Ottawa, OntarioAges 18 years+ - NCT06399952Recruiting
Natural history study for Baker Gordon syndrome
This study follows people with Baker Gordon syndrome over time to better understand the condition. Participants and their caregivers share medical records and complete tests and questionnaires.
Columbia, MissouriAges birth–99 years - NCT07390539RecruitingPhase 1
CAR T cells targeting B7-H3 for brain tumors
This trial tests a new type of immune therapy (CAR T cells) that targets a protein called B7-H3 found on some brain tumors. It is for children and young adults with certain brain or spinal cord tumors that have come back after standard treatment, and aims to see if the treatment is safe and effective.
Boston, MassachusettsAges 2–21 - NCT06335836Recruiting
Social connections and brain health in memory decline
This study looks at how being socially isolated or socially active affects memory and brain health in people who feel their thinking is getting worse. You may join if you notice a slow decline in memory or thinking, but otherwise have normal test results.
Nanjing, China, JiangsuAges 45–85
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Common questions
- Are there clinical trials for brain diseases?
- Yes. Clin2 currently lists 328 recruiting brain diseases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain diseases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain diseases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.