Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,059 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04286516Recruiting
Brain and robot training for arm movement after stroke
This study tests whether brain stimulation and robotic/arm training can improve arm movement in people who had a stroke. It may help strengthen movement and coordination by targeting brain pathways related to arm control.
Pittsburgh, PennsylvaniaAges 45–90 - NCT04306432Recruiting
Check how cognitive tests change after brain tumor radiation
This trial studies how radiation therapy affects thinking and memory in adults with certain brain tumors. It may help doctors understand which patients are more likely to have cognitive side effects and how to measure them over time.
Copenhagen, Capital RegionAges 18–100 - NCT04349852Recruiting
Memory and attention training for adults after brain injury
This trial tests a therapy that helps improve verbal working memory and attention in adults who had a traumatic brain injury (TBI). It may help by training thinking skills that are often affected after an injury, but it’s only for people who meet timing and mental health substance-use requirements.
New York, New YorkAges 18 years+ - NCT04383808Recruiting
PET/MRI scan with a small injected tracer
This study tests a new brain PET “insert” that can work at the same time as MRI to create brain images. If you’re healthy and can receive an approved injected tracer (FDG or Neuraceq), you may be able to help confirm the device works safely and clearly.
Palo Alto, CaliforniaAges 21 years+ - NCT04397978Recruiting
Radiation for 4–10 brain metastases with a few tumor limits
This trial tests a local treatment approach (focused radiation) for people with multiple brain metastases. It may help by targeting several spots in the brain while keeping treatment within certain size and safety limits.
LeuvenAges 18 years+ - NCT04400266RecruitingPhase 4
Buspirone and melatonin for depression after a brain injury
This trial studies whether the medicines buspirone and melatonin can reduce depression symptoms in people who had a mild or moderate traumatic brain injury (TBI) at least 3 months ago. It may help if you have ongoing depression after TBI and can safely take study medications and attend regular visits, including MRI scans.
Boston, MassachusettsAges 18–64 - NCT04421365Recruiting
Brain–computer interface study for voice spasms from laryngeal dystonia
This study tests how a brain–computer interface reads brain signals to understand and possibly support people with a specific voice condition called adductor laryngeal dystonia. It also compares results with healthy people to help researchers see how brain activity differs during voice tasks.
Boston, MassachusettsAges 18–80 - NCT04449068Recruiting
Tourette research using records from deep brain stimulation patients
This study is collecting information about people with severe Tourette syndrome who are not adequately helped by medication and may receive deep brain stimulation. It helps researchers understand outcomes and care patterns for this treatment over time using an observational database.
ParisAges 15 years+ - NCT04499755RecruitingPhase 3
Nucleo CMP Forte for moderate to severe brain injury in children
This trial studies whether a supplement called Nucleo CMP Forte can improve outcomes after a moderate or severe traumatic brain injury in children. It may help families see if adding this treatment makes recovery better and safer.
TantaAges Up to 18 years - NCT04511013RecruitingPhase 2
Trial for BRAF-mutant melanoma spread to the brain
This Phase 2 study tests whether a 3-drug plan (encorafenib + binimetinib + nivolumab) works better than ipilimumab + nivolumab for melanoma that has spread to the brain. If you qualify, you’ll get either treatment and have frequent brain scans to track how well it controls the tumors.
Birmingham, AlabamaAges 18 years+ - NCT04524637Recruiting
Testing a clotting test in recent traumatic brain injury
This trial tests whether a special blood clotting test called thromboelastography can help assess clotting problems after a head injury. It may help doctors better understand bleeding risk and related complications early after trauma.
ShanghaiAges 18–80 - NCT04654975Recruiting
Metastatic brain tumors after esophagus surgery study
This study looks at people who had esophageal cancer surgery and later developed brain metastases. It may help doctors better understand who benefits from treatment planning after the original cancer surgery.
Houston, TexasAges Any age - NCT04692337Recruiting
Ommaya device for easier testing of brain tumor fluid
This study places a small device in the brain area (called an Ommaya reservoir) so doctors can collect brain fluid to test tumor markers over time. It may help researchers learn more about brain tumors, while also fitting alongside your planned brain surgery at Mayo Clinic.
Rochester, MinnesotaAges 18 years+ - NCT04758624Recruiting
Study brain changes after deep brain stimulation for tremor
This study looks at how brain “wiring” (connectivity) and brain function change over time in people with essential tremor after successful deep brain stimulation. You might benefit by helping researchers better understand what DBS does in the brain, which can improve care for others with tremor.
Manhasset, New YorkAges 18–85 - NCT04805255Recruiting
Study brain-targeted radiation for limited brain metastases
This study looks at people with a small number of brain metastases who are treated with a focused, staged form of radiation after surgery or to treat the cancer. It may help doctors better understand how well this approach works and who benefits most.
TaoyuanAges 18–84 - NCT04833335Recruiting
MRI scans to tell tumor spread from radiation injury
This trial studies how a special MRI can help doctors tell whether brain lesions after Gamma Knife treatment are growing tumors or radiation injury. It may help you avoid unnecessary treatment if the findings suggest radionecrosis instead of progression.
ParisAges 18 years+ - NCT04847284Recruiting
Radiation during brain tumor surgery for brain metastases
This trial tests giving targeted radiation while surgeons are operating to treat brain metastases. It may help control the cancer locally at the time of surgery, especially for certain single lesions.
BarcelonaAges 18 years+ - NCT04855396Recruiting
Study of blood markers during hyperbaric oxygen brain injury care
This trial looks at blood “biomarkers,” or lab measurements, while people receive hyperbaric oxygen treatment for brain injury as part of the main HOBIT study. It may help researchers understand who benefits and why by improving how treatment responses are tracked.
San Diego, CaliforniaAges 16–65 - NCT04869059Recruiting
tDCS for mild brain injury memory word finding
This trial tests whether a noninvasive brain stimulation treatment (tDCS) can improve word-retrieval problems after a mild or moderate concussion-like brain injury. It may help if testing shows trouble finding the right words when speaking.
Dallas, TexasAges 18–75 - NCT04898491Recruiting
Pain behavior scale study for adults who cannot speak
This study checks whether a “pain behavior” checklist works well and gives consistent results in adults who can’t communicate verbally and who have an artificial airway. It may help clinicians better recognize pain in people who cannot tell them directly.
Madrid, MadridAges 18 years+ - NCT04905264Recruiting
Studying factors and care quality after severe brain injury
This study looks at how outcomes and care quality vary for people with serious acquired brain injuries while in a rehabilitation unit. It may help clinicians understand what care works best and why.
AlessandriaAges 18 years+ - NCT04923542RecruitingPhase 1/Phase 2
Targeted drug plus focused brain radiation for breast cancer
This study tests whether abemaciclib (a targeted pill) given with focused radiation to brain tumors can control hormone receptor–positive, HER2-negative breast cancer in the brain. It’s designed to see if the combination helps shrink or slow the growth of brain metastases while keeping side effects manageable.
Tampa, FloridaAges 18 years+ - NCT06888817RecruitingPhase 3
Bevacizumab vs steroids for brain radiation injury
This trial tests if bevacizumab works better than steroids for people with brain swelling caused by radiation. If you have this condition and meet certain health requirements, you may join.
AmsterdamAges 18 years+ - NCT07698665Recruiting
Ketamine vs dexmedetomidine in scalp block for brain tumor surgery
This trial compares two medicines, ketamine and dexmedetomidine, added to a scalp nerve block during brain tumor removal surgery. The goal is to see which provides better pain control and recovery after surgery.
Cairo, GovernorateAges 20–60
Hear when a new Brain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,059 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.