Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,059 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05755919Recruiting
Brain mapping during epilepsy surgery with special brain electrodes
This study looks at how to map brain function in people having epilepsy surgery by recording brain signals using special electrodes placed on or inside the brain. It may help doctors better understand which brain areas cause seizures.
Detroit, MichiganAges 6 months–21 years - NCT05756985Recruiting
Providing fresh brain tissue to better understand glioblastoma
This study aims to improve understanding of glioblastoma (and gliosarcoma) by preserving live, usable brain-tissue samples during brain surgery. If you’re having repeat tumor surgery or your scans suggest these cancers, the study may ask to collect tissue for research.
Miami, FloridaAges 18 years+ - NCT05764538RecruitingPhase 2
Drug trial for brain fog after COVID-19
This Phase 2 trial tests DAOIB to improve “brain fog” and thinking problems that happen after COVID-19. You may be screened if your symptoms started after a COVID infection and have lasted for months, and if your health tests are normal.
Kaohsiung CityAges 18–100 - NCT05765162Recruiting
Research study on safer, more tailored anesthesia
This study looks at safer anesthesia—meaning medicines used during procedures—using a more personalized approach. It may help make anesthesia safer for adults having medical procedures.
Nykøbing FalsterAges 18–100 - NCT05766059Recruiting
Noninvasive brain stimulation to aid stroke or phantom limb pain rehab
This trial tests new, noninvasive brain stimulation techniques to help recovery after stroke weakness or after arm amputation with phantom limb pain. If you fit the type and timing of your condition, the study may help improve pain or hand/arm function without surgery.
Milan, LombardyAges 18–85 - NCT05769010RecruitingPhase 2
HER2-positive or low breast cancer brain metastasis drug study
This Phase 2 study tests SHR-A1811 in people with HER2-positive (or HER2-low) advanced breast cancer that has spread to the brain. It aims to shrink brain tumors and control the cancer in the brain, especially when there was no need for urgent local treatment like radiation or surgery.
Zhengzhou, HenanAges 18–75 - NCT05770544RecruitingPhase 2/Phase 3
Entrectinib for ROS1 fusion cancers with matching gene test
This trial studies entrectinib, a targeted pill, in people whose cancer has a specific gene change called ROS1 fusion. It may help by shrinking tumors that depend on this ROS1 gene switch, and the study requires starting with a new tissue sample and treatment monitoring.
BelfastAges Any age - NCT05771844Recruiting
Home sleep treatment for older adults with memory changes
This study tests whether a home sleep therapy program can improve symptoms in older adults who have amnestic mild cognitive impairment (MCI) or help compare to people without MCI. It may be useful if your main issue is memory or thinking changes and you also have sleep problems.
Winston-Salem, North CarolinaAges 40–85 - NCT05775458Recruiting
Study of treatments for aggressive brain tumor cell damage
This study looks at glioblastoma (GBM), a very aggressive brain tumor, and how “brain cell overload” (glutamate excitotoxicity) may affect tumor growth. It focuses on adults who are planned for complete tumor removal, followed by standard radiation and chemotherapy.
Milan, MilanAges 18 years+ - NCT05776563Recruiting
Testing whether brain sugar transport improves in type 2 diabetes
This study looks at whether the way the brain uses sugar (glucose) in people with type 2 diabetes can improve, and whether changes track with tighter diabetes treatment. You may get brain scans (MRI/MRS) and diabetes monitoring to see if there’s “reversibility” in the brain’s sugar transport.
New Haven, ConnecticutAges 18–60 - NCT05780905RecruitingPhase 4
Semaglutide study for brain blood flow in type 2 diabetes
This trial tests whether semaglutide changes blood flow in the brain and the brain’s “barrier” (how well the brain is protected) in people with type 2 diabetes. It may help researchers understand brain-related effects of diabetes treatment using scans and blood tests.
Seattle, WashingtonAges 40–65 - NCT05782244RecruitingPhase 2
Sildenafil trial for long-term brain blood-flow problems after TBI
This Phase 2 study tests whether sildenafil (a medication better known for erectile function) can improve long-term symptoms and brain blood-flow issues after a past traumatic brain injury (TBI). It may help by improving blood vessel function in the brain and possibly reducing persistent post-concussion symptoms.
Philadelphia, PennsylvaniaAges 18–70 - NCT05786924RecruitingPhase 1/Phase 2
Targeted cancer drug study for RAS/RAF mutation-positive tumors
This Phase 1/2 study tests S241656 (a targeted cancer medicine) in people whose cancers have certain “RAS/RAF” gene changes. It may help shrink tumors or control cancer growth, and also finds the safest dose and best way to use the drug.
Gilbert, ArizonaAges 18 years+ - NCT05795686Recruiting
Study of the AVanCer day-center support program for patients
This study looks at how a day-center support program (AVanCer) affects patients and their caregivers. If you join, you may complete questionnaires and help researchers understand your experiences through assessments in French.
BronAges 18 years+ - NCT05811312Recruiting
Spinal cord stimulation and brain changes in chronic pain
This study uses non-invasive brain monitoring to see how spinal cord stimulation may change brain activity in people with chronic nerve pain. It aims to better understand how treatment affects the brain and pain over time.
Cleveland, OhioAges 18 years+ - NCT05813223RecruitingEarly Phase 1
Gefapixant to study brain activity in chronic cough
This early study tests whether gefapixant changes brain activity related to cough in people with chronic cough that hasn’t improved with usual treatments. It may help researchers understand why chronic cough happens and how to better treat it.
Parkville, VictoriaAges 18–65 - NCT05818410Recruiting
Brain and tech training after below-knee leg loss
This study looks at how your brain works with assistive technology after losing a leg below the knee. It may help researchers improve how prosthetic devices feel and function by measuring brain and movement signals during training.
BrusselsAges 18–65 - NCT05823454Recruiting
Testing brain-connection changes during propofol sedation
This study looks at how the brain network connects during propofol sedation in people with long-lasting disorders of consciousness. It may help doctors understand brain function in these conditions and improve how care is guided during procedures.
BeijingAges 18–65 - NCT05830266Recruiting
Mindfulness program to help mother–baby bonding in pregnancy and after
This study tests a mindfulness-based program to improve mother–baby bonding by supporting mood, anxiety, and stress during and after pregnancy. It may help if you’re currently having higher-than-average depression, anxiety, or stress symptoms.
Tilburg, North BrabantAges 18 years+ - NCT05830942Recruiting
Training walks plus brain stimulation for thinking skills in older adults
This study tests whether a structured walking exercise, combined with brain stimulation and brain scans, can improve or slow decline in thinking skills. It’s aimed at older adults who notice memory or confusion getting worse.
Gainesville, FloridaAges 65 years+ - NCT05837676Recruiting
Problem-solving training for concussion symptoms
This trial tests whether a structured problem-solving skill program can improve mood and thinking symptoms after a concussion. It may help Veterans who have had concussion symptoms for several months and are currently feeling psychological distress.
Buffalo, New YorkAges 18 years+ - NCT05839379Recruiting
Targeted therapy study for children and young adults with brain tumors
This trial studies a targeted medicine approach for high-grade glioma (a fast-growing brain tumor) and some diffuse midline tumors, including DIPG. It may help by matching treatment to tumor biology using tumor testing done before or around starting standard therapy.
Aurora, ColoradoAges 1–39 - NCT05840575Recruiting
Study of thinking changes in young people during cancer treatment
This study looks at how thinking and memory may change in children and young adults after a new cancer diagnosis, especially around chemotherapy. It may help doctors better understand and track brain-related side effects early.
CopenhagenAges 7–29 - NCT05843253RecruitingPhase 2
Ribociclib plus everolimus or temozolomide for certain brain tumors
This Phase 2 study tests ribociclib with either everolimus or temozolomide, depending on the specific brain tumor type. It may help slow tumor growth in children and young adults whose tumor has specific genetic changes and who have had recent standard radiation therapy.
Aurora, ColoradoAges 1–39
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,059 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.