Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,059 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05847985Recruiting
Noninvasive brain stimulation for thinking and language issues
This study tests whether a noninvasive brain stimulation treatment can improve sentence understanding in people with Parkinson’s disease–related mild cognitive impairment or mild cognitive impairment from Lewy body disease. It also compares results with healthy volunteers who do not have Lewy body or other memory/brain disorders.
BrnoAges 60–80 - NCT05895019Recruiting
Propofol’s effects on brain function in Parkinson’s surgery
This study tests how propofol, a common anesthesia medicine, affects brain activity in people with Parkinson’s disease during planned surgery. It also compares them with people without Parkinson’s during similar non-brain, non-heart surgery.
Beijing, Beijing MunicipalityAges 18–80 - NCT05850247RecruitingPhase 2
Study brain inflammation in carotid artery narrowing after stroke or TIA
This Phase 2 study looks at a protein called ficolin-2 and whether it relates to brain inflammation after a short stroke-like event or eye blood vessel blockage caused by narrowed carotid arteries. If you recently had symptoms from the carotid artery and meet imaging and health criteria, you may be offered study-related assessments to better understand the cause and help future treatment decisions.
BronAges 18 years+ - NCT05855525Recruiting
Brain scan study that uses real-time fMRI and quick prompts
This study uses an MRI brain scan that can monitor brain activity in real time while you answer brief experience questions. It’s meant to help researchers understand how brain signals relate to people’s moment-to-moment experiences.
Philadelphia, PennsylvaniaAges 18–35 - NCT05857969RecruitingPhase 1
Testing cancer drug response on removed tumor tissue
This early study uses tumor tissue (or bone marrow from blood cancers) and performs lab tests to see which cancer drugs may work better for each person. It also collects genetic information from blood or a saliva swab to help understand why cancers respond differently.
Miami, FloridaAges 1 day–21 years - NCT05859334RecruitingPhase 2
Erdafitinib for brain tumors that came back or worsened
This Phase 2 study tests erdafitinib, a targeted anti-cancer medicine, for certain brain cancers that have returned or progressed after standard treatment. It may help if your tumor has a specific genetic change (FGFR-TACC fusion) that this drug is designed to attack.
Aurora, ColoradoAges 18 years+ - NCT05864794Recruiting
Screening brain MRI in advanced lung cancer patients
This trial looks at whether doing an MRI scan of the brain for people with stage IV lung cancer helps in their care. The goal is to find brain issues early (if present) so treatment decisions can be made sooner.
Groningen, Provincie GroningenAges 18 years+ - NCT05866432RecruitingPhase 2
Dato-DXd for triple-negative breast cancer brain metastases
This trial studies Dato-DXd (an antibody-drug medicine) in people with triple-negative breast cancer that has spread to the brain. It aims to see how well it controls brain tumors when they are newly found or growing after other treatments.
Vienna, State of ViennaAges 18–100 - NCT05867472RecruitingPhase 3
Sedation plan for critically ill children on breathing machines
This Phase 3 trial tests a sedation approach using inhaled (“volatile”) anesthesia gases for children who need a ventilator. It aims to improve comfort and brain-related outcomes while they stay on the breathing machine for at least a day.
Hamilton, OntarioAges 1 month–18 years - NCT05871372Recruiting
Study brain circuits behind mood using brain monitoring
This study looks at how brain networks relate to mood and depression by recording brain activity during specific procedures. You may be able to join if you’re already having brain monitoring for epilepsy or are part of a depression deep brain stimulation program.
Houston, TexasAges 21–70 - NCT05877560Recruiting
Noninvasive brain stimulation for eye focusing trouble
This study tests a noninvasive brain stimulation treatment to improve symptoms of convergence insufficiency, a condition that makes near vision tasks like reading harder. You may be randomly assigned to the study treatment or a comparison condition.
Downers Grove, IllinoisAges 18–40 - NCT05881239Recruiting
Remote smell tests to track early Alzheimer’s health changes
This trial uses remote, at-home (or remote) smell-based testing to help researchers assess health in people with preclinical Alzheimer’s disease and in control participants. It may help by showing how well smell-related changes can signal disease status over time.
Boston, MassachusettsAges 18–100 - NCT05884736Recruiting
Checking no blood flow to the brain during certain organ donation
This study looks at whether there is truly no blood flow to the brain during a specific type of organ donation. It aims to confirm safety and timing by using neurological monitoring during the process.
London, OntarioAges 18–75 - NCT05884762Recruiting
Brain training rehab for arm recovery after a recent stroke
This trial tests an upper-limb (arm/hand) rehabilitation program guided by brain activity signals, started soon after a stroke. It may help people with early incomplete arm recovery improve hand and arm function.
RennesAges 18–80 - NCT05885295Recruiting
Testing thinking and memory after stroke using cognitive exams
This study looks at how thinking and memory change after a stroke using short cognitive tests. It may help researchers better understand which brain changes affect thinking, and how to measure them accurately.
LondonAges 18 years+ - NCT05886114Recruiting
Lifestyle program to help older adults at risk of memory decline
This trial tests a multi-part lifestyle program to help older adults who may be starting to decline in thinking and memory. It may help slow cognitive decline by combining lifestyle changes over 24 months.
Hangzhou, ZhejiangAges 60–80 - NCT05890781Recruiting
Study pediatric cancer using lab-made immune organoids
This trial uses special lab models (“immune organoids”) to study certain cancers in children and young people. It may help researchers learn what those cancers do and improve future treatment ideas.
VillejuifAges Up to 25 years - NCT05892952Recruiting
Scottish long-term study of aging and thinking
This study follows adults aged 50 and older over time to understand how thinking and memory change. You may help researchers learn what influences healthy aging and cognitive health.
Edinburgh, LothianAges 50–120 - NCT05892510RecruitingPhase 2/Phase 3
Tenecteplase after clot removal for no-reflow stroke
This trial tests whether giving tenecteplase directly into the brain artery after a thrombectomy can improve outcomes when blood flow doesn’t fully return (“no-reflow”) in an emergency stroke. It may help some people by reducing ongoing clot-related blockage after the main clot is removed.
Gold Coast, QueenslandAges 18 years+ - NCT05892744RecruitingPhase 4
Testing brain scans to help choose depression treatment
This trial studies how brain signals measured by MRI and EEG may help doctors choose the best treatment for depression. It focuses on people with early-onset, long-lasting or recurring major depression, and tests whether these “brain biomarkers” track with treatment choice and response.
Austin, TexasAges 18–65 - NCT05893407Recruiting
Ultrasound test of brain blood flow in ICU injury
This trial tests whether a contrast-enhanced ultrasound can measure blood flow in the brain of people admitted to the ICU for a sudden brain injury. It may help doctors better assess brain damage and guide care using a bedside imaging method.
ParisAges 18 years+ - NCT05900778Recruiting
HABIT-ILE program for school-aged children after brain injury
This trial tests whether a structured HABIT-ILE program helps children with a brain injury improve daily functioning at school and during therapy sessions. It may help families build skills and routines, but it requires meeting specific health and timing criteria.
Ottignies-Louvain-la-Neuve, Brabant-WallonAges 5–18 - NCT05905705Recruiting
ECT plus a sleep monitor for treatment-resistant depression
This study looks at how electroconvulsive therapy (ECT) affects brain activity and sleep patterns in people with difficult-to-treat depression. It uses a wearable sleep monitor (the Dreem device) to record sleep while you receive ECT.
St Louis, MissouriAges 21–65 - NCT05906056Recruiting
CPM therapy vs bone overgrowth in hip or knee
This study compares continuous passive motion (a machine that gently moves a joint without you moving it) versus the body’s tendency to form extra bone called heterotopic ossification. It aims to see whether CPM can affect how and how much bone overgrowth develops after neurologic injuries like stroke, brain injury, or spinal cord injury.
Ioannina, EpirusAges 15–70
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,059 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.