Clinical trials · North Carolina
Breast Cancer Stage I clinical trials in North Carolina
We’re tracking 71 recruiting breast cancer stage i studies with a site in North Carolina — including Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT06727773RecruitingPhase 2
Memantine and exercise to protect thinking during chemo for breast cancer
This study tests whether a medicine called memantine combined with a structured exercise program can help protect your thinking and memory during chemotherapy for breast cancer. It may also help understand how these treatments work in the body.
Chapel Hill, North CarolinaAges 18 years+ - NCT06878547Recruiting
Ultrasound study for breast cancer tissue structure
This study uses a special ultrasound technique (VisR) to look at the structure of breast tissue and collagen in women with suspicious or known breast cancer. The goal is to see if this imaging can help doctors better understand breast cancer without needing a biopsy.
Chapel Hill, North CarolinaAges 20–90 - NCT06896474Recruiting
Breast cancer treatment choice help for women 70 and older
This study tests a decision aid to help women 70 and older with early stage breast cancer choose their treatment. It looks at whether the tool helps patients and their doctors make a confident treatment choice.
Durham, North CarolinaAges 18 years+ - NCT06902311RecruitingPhase 2
Shorter radiation after lumpectomy for early breast cancer
This trial tests a shorter, more intense course of daily radiation therapy (called ultra hypo-fractionation) given after lumpectomy for early-stage breast cancer. The goal is to reduce the number of treatment visits while keeping the same high level of effectiveness and safety.
Chapel Hill, North CarolinaAges 50 years+ - NCT06958328RecruitingPhase 3
Testing higher dose radiation for locally advanced pancreatic cancer
This trial tests if a higher dose of radiation therapy can help people with locally advanced pancreatic cancer after they've had 4–6 months of chemotherapy. It aims to improve cancer control without significantly increasing side effects.
Chapel Hill, North CarolinaAges 18 years+ - NCT07009093Recruiting
Mobile app for young women with breast cancer
This study tests a mobile app called Mighty Pro to help young women with breast cancer manage stress. It is for women ages 18–45 who are patients at a specific cancer center and feel some distress.
Charlotte, North CarolinaAges 18–45 - NCT07025785Recruiting
Testing for tumor DNA in blood after early-stage breast cancer surgery
This study looks for tiny bits of tumor DNA in your blood after surgery to see if it can help guide future treatment. It's for people who had surgery first (not chemotherapy before surgery) and have not seen the cancer spread.
Chapel Hill, North CarolinaAges 18 years+ - NCT07069595RecruitingPhase 2
Blood test for breast cancer survivors at risk of recurrence
This trial uses a simple blood test to look for leftover cancer DNA in people with triple-negative breast cancer who still have disease after chemotherapy and surgery. It aims to catch any early signs of the cancer coming back.
Chapel Hill, North CarolinaAges 18 years+ - NCT01042379RecruitingPhase 2
Adaptive drug trial for newly diagnosed breast cancer
This study tests personalized, changing treatment plans (given before surgery) to find better options for your specific breast tumor. You may be asked for extra breast-tissue testing to help match you with the most suitable study drug(s).
Winston-Salem, North CarolinaAges 18 years+ - NCT02734537RecruitingPhase 2
Radiation with or without cisplatin after head and neck surgery
This trial studies whether adding cisplatin (a chemotherapy medicine) to radiation therapy helps people with stage III–IVA squamous cell cancer of the head and neck after they’ve had surgery. It’s meant to lower the risk of the cancer coming back.
Chapel Hill, North CarolinaAges 18 years+ - NCT02945579Recruiting
Testing skipping breast surgery or radiation for top responders
This trial studies whether some people with early-stage breast cancer who respond extremely well to hormone/chemo/targeted treatment can safely skip breast surgery and/or radiation. It aims to reduce side effects without increasing cancer risk in carefully selected patients.
Charlotte, North CarolinaAges 30 years+ - NCT07474090Recruiting
Personalized Exercise Program for Breast Cancer Survivors
This study tests whether a personalized exercise program during chemotherapy helps breast cancer survivors recover better and feel stronger. You'll use a smartphone app to do guided workouts at home while getting support from exercise coaches.
Winston-Salem, North CarolinaAges 18–85 - NCT03424005RecruitingPhase 1/Phase 2
Testing new drug combinations for advanced breast cancer
This study tests how well and how safely different combinations of cancer drugs work for people with metastatic or inoperable locally advanced breast cancer. It may help by finding a better treatment option and collecting information to guide future care.
Durham, North CarolinaAges 18 years+ - NCT05827081RecruitingPhase 3
Ribociclib plus endocrine therapy for early breast cancer
This trial studies whether adding ribociclib to standard hormone (endocrine) therapy lowers the risk of breast cancer coming back in early-stage, hormone-receptor–positive cancer. It mainly looks at safety and how well the treatment controls cancer after surgery and (sometimes) prior hormone treatment.
Durham, North CarolinaAges 18–100 - NCT05501704RecruitingPhase 2
Testosterone-blocking therapy for male breast cancer
This Phase 2 study tests an oral treatment (called “ET”) to treat hormone-receptor–positive, HER2-negative invasive breast cancer in men. It may help shrink or control cancer without using standard cancer treatments first.
Chapel Hill, North CarolinaAges 18 years+ - NCT06896162Recruiting
Genetic test to guide first or second treatment for advanced cancer
This study looks at whether using a detailed genetic test of your tumor can help pick the best first or second treatment for advanced lung, colon, breast, or bladder cancer. The goal is to see if this personalized approach helps people live longer.
Chapel Hill, North CarolinaAges 18 years+ - NCT04468061RecruitingPhase 2
Study chemo drug plus immunotherapy for metastatic triple-negative breast cancer
This trial tests sacituzumab govitecan (an antibody-drug medicine) with or without pembrolizumab (an immune-system therapy) in people with metastatic triple-negative breast cancer. It may help by shrinking tumors and improving immune control, especially for patients with specific tumor marker results.
Chapel Hill, North CarolinaAges 18 years+ - NCT04893109RecruitingPhase 2
Study compares two HER2 breast cancer treatments after surgery
This Phase 2 study tests two different medicines given after breast surgery to reduce the risk of cancer coming back. It is only for people with early-stage HER2-positive breast cancer with limited or no lymph node spread.
Durham, North CarolinaAges 18 years+ - NCT02422641RecruitingPhase 2
High-dose methotrexate for breast cancer in the brain lining
This Phase 2 trial tests whether giving high-dose methotrexate into the bloodstream can help treat breast cancer that has spread to the thin lining covering the brain and spinal cord. It may help reduce cancer in the leptomeningeal (brain-lining) area and control symptoms.
Winston-Salem, North CarolinaAges 18 years+ - NCT06555588Recruiting
Supportive talk therapy for advanced cancer symptoms
This study tests a supportive talk therapy program (called Engage) delivered via video calls. It aims to help people with advanced cancer manage tough symptoms like pain, fatigue, and distress and improve daily functioning.
Durham, North CarolinaAges 18 years+ - NCT06492616RecruitingPhase 3
Elacestrant vs standard hormone therapy for high-risk early breast cancer
This trial tests a new hormone therapy pill (elacestrant) against standard hormone therapy for people with a common type of early breast cancer (ER+, HER2-) that has a higher chance of returning. You may qualify if you've already been on hormone therapy for 2 to 5 years and want to see if a different pill works better.
Durham, North CarolinaAges 18 years+ - NCT07140172Recruiting
Radiation or surgery for node-positive breast cancer
This trial compares two treatments for people with breast cancer that has spread to the lymph nodes: radiation therapy to the armpit or surgery to remove the lymph nodes. The goal is to see which approach works best after a tailored surgery to remove the most suspicious lymph nodes.
Durham, North CarolinaAges 18 years+ - NCT07214532Recruiting
Guiding CDK4/6 inhibitor use by a blood test in breast cancer
This trial is for women and men with early-stage, hormone-positive, HER2-negative breast cancer. It uses a blood test (Signatera) to detect tiny amounts of cancer DNA and only starts a CDK4/6 inhibitor (ribociclib or abemaciclib) if the test shows cancer DNA is present.
Charlotte, North CarolinaAges 18 years+ - NCT04181060RecruitingPhase 3
Osimertinib alone or with bevacizumab for EGFR-mutant lung cancer
This Phase 3 trial tests whether starting osimertinib with or without bevacizumab helps people with advanced EGFR-mutant lung cancer live longer and control the cancer better. Your EGFR mutation test result and past treatments are key to whether you can join.
Charlotte, North CarolinaAges 18 years+
Where these studies are running in North Carolina
Institutions with a site for the recruiting breast cancer stage i studies listed above.
- UNC Lineberger Comprehensive Cancer Center · 7 studies
- University of North Carolina at Chapel Hill · 3 studies
- Cone Health Cancer Center · 2 studies
- Duke Cancer Center · 2 studies
- Duke Cancer Institute · 2 studies
- Duke University Medical Center · 2 studies
- Levine Cancer Institute · 2 studies
- Southeastern Medical Oncology Center · 2 studies
What taking part in a breast cancer stage i study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Breast Cancer Stage I trials in other states
Common questions
- Are there breast cancer stage i clinical trials in North Carolina?
- Yes. We're currently tracking 71 recruiting breast cancer stage i studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a breast cancer stage i study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a breast cancer stage i trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New breast cancer stage i studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.