Clinical trials
Breast Cancer Stage III clinical trials
Below are recruiting breast cancer stage iii clinical trials, each written for real people, not researchers. We’re tracking 527 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06889688RecruitingPhase 3
New drug combo vs. chemo for advanced triple-negative breast cancer
This trial tests a new combination of three drugs (camrelizumab, apatinib, and eribulin) against the standard chemotherapy chosen by your doctor. It's for people with advanced triple-negative breast cancer that has gotten worse after previous treatments.
Guangzhou, GuangdongAges 18–70 - NCT06905301Recruiting
Study on breast cancer medication with a mobile app
This study compares how well breast cancer patients take their medication (ribociclib) with or without using a mobile app. It aims to see if the app helps patients stick to their treatment plan.
Pskov, RussiaAges 18–90 - NCT06926543RecruitingPhase 3
Timing of radiation with chemotherapy for breast cancer
This trial compares two ways of giving radiation therapy to people with stage IIB or III breast cancer: either at the same time as chemotherapy or after chemotherapy finishes. It aims to find which approach works better while keeping side effects manageable.
Vishkhapatnam, Andhra PradeshAges 18 years+ - NCT06927180RecruitingPhase 2
Study of SHR-A1811 plus pertuzumab before surgery for HER2+ breast cancer
This trial tests a combination of two targeted drugs (SHR-A1811 and pertuzumab) given before surgery to shrink HER2-positive breast cancer. It aims to see if this approach improves outcomes for patients with early-stage but high-risk disease.
Zhengzhou, HenanAges 18–70 - NCT06930521Recruiting
Monitoring heart health during HER2 therapy for breast cancer
This study tracks how well the heart handles HER2-targeted therapy (like Herceptin) during the first year of treatment for early-stage breast cancer. It helps keep you safe by checking heart function closely.
Toronto, OntarioAges 18–79 - NCT06931548Recruiting
Preserving the breast fold in reconstruction
This study tests a surgical technique to better preserve the natural fold under the breast (the inframammary fold) during implant-based breast reconstruction. It may help improve the cosmetic result after breast cancer treatment.
Moscow, Skolkovo Innovation CenterAges 18 years+ - NCT06931769Recruiting
Optimizing treatment for stage III triple-negative breast cancer
This trial studies the best ways to give chemotherapy before and after surgery for stage III triple-negative breast cancer. It aims to improve treatment outcomes by using a personalized approach and patient-reported data.
Enschede, OverijsselAges 18 years+ - NCT06949410RecruitingPhase 1
HER2 vaccine study for high-risk breast cancer
This trial tests a vaccine designed to help the immune system fight remaining HER2-positive breast cancer cells after standard treatment. It is for people who have completed at least six months of HER2-targeted therapy and still have a high risk of the cancer coming back.
Indianapolis, IndianaAges 18 years+ - NCT06954831RecruitingPhase 2
Short-course radiation for early-stage breast cancer
This trial tests a shorter, more intense radiation schedule for people with stage I-III breast cancer after lumpectomy. It aims to find if giving a higher daily dose over fewer sessions is safe and effective.
Arcadia, CaliforniaAges 40 years+ - NCT06958328RecruitingPhase 3
Testing higher dose radiation for locally advanced pancreatic cancer
This trial tests if a higher dose of radiation therapy can help people with locally advanced pancreatic cancer after they've had 4–6 months of chemotherapy. It aims to improve cancer control without significantly increasing side effects.
Gilbert, ArizonaAges 18 years+ - NCT06961955RecruitingPhase 2
Shorter versus longer whole breast radiation for early-stage breast cancer
This trial compares a 5-day course of whole breast radiation plus a boost to the standard 9-day course for people with early-stage breast cancer who have certain risk factors, such as high-grade tumors or younger age. The goal is to see if the shorter treatment is just as safe and effective.
Salt Lake City, UtahAges 18 years+ - NCT06966050Recruiting
Blood test registry for inflammatory breast cancer
This study collects blood samples from people with inflammatory breast cancer (IBC) to learn more about the disease. It uses a special blood test called Signatera to look for cancer DNA, and the information is stored in a registry for research.
Houston, TexasAges 18 years+ - NCT06989450Recruiting
Digital support for women on hormone therapy for breast cancer
This trial tests a smartphone app called Sidekick to help women with early-stage breast cancer stick to their hormone therapy and feel more confident managing their health. If you were diagnosed with stage I, II, or III breast cancer after September 2023 and are starting hormone therapy, this program might help you stay on track.
ReykjavikAges 18 years+ - NCT06997068RecruitingPhase 2
Drug combination for returning head and neck cancer
This trial tests a combination of three drugs—methotrexate, erlotinib, and celecoxib—for people whose head and neck cancer has come back or spread. It is designed for patients in the rural Midwest who have already had or chosen not to have standard first treatment.
Rochester, MinnesotaAges 18 years+ - NCT07012031RecruitingPhase 1/Phase 2
Sotorasib and trastuzumab deruxtecan for KRAS G12C lung cancer
This trial tests a combination of two drugs, sotorasib and trastuzumab deruxtecan, for people with advanced or metastatic non-small cell lung cancer that has a KRAS G12C mutation. It may be an option if you've already had treatment with a KRAS G12C inhibitor, immunotherapy, and chemotherapy.
Sacramento, CaliforniaAges 18 years+ - NCT07016399RecruitingPhase 2
Darolutamide before surgery for AR-positive triple-negative breast cancer
This trial tests a drug called darolutamide, alone or with standard chemotherapy, before surgery for a type of breast cancer that is triple-negative but has a high level of the androgen receptor (AR). It is for people with stage II or IIIA breast cancer that can be removed surgically.
Nashville, TennesseeAges 18 years+ - NCT07018986Recruiting
MIND Diet Study for breast cancer-related memory problems
This study tests whether the MIND diet (a brain-healthy eating plan) can improve memory, thinking, and other cognitive problems that many breast cancer survivors experience after treatment.
Tampa, FloridaAges 18 years+ - NCT07037576Recruiting
Breast reconstruction study for patients needing radiation after mastectomy
This study compares two types of breast reconstruction for women who need radiation therapy after their mastectomy: one-stage reconstruction using a permanent implant placed in front of the chest muscle, versus the standard two-stage approach where a tissue expander is used first and replaced with a permanent implant later. The goal is to see which method works better and is safer for patients who require post-mastectomy radiation.
Henan, HenanAges 18–70 - NCT07042581RecruitingPhase 4
Revaree Plus for vaginal dryness in breast cancer survivors
This trial tests a vaginal insert called Revaree Plus to see if it helps breast cancer survivors who have vaginal dryness or pain from hormone therapy. It may be a good option if you are on an aromatase inhibitor or tamoxifen and have discomfort.
Basking Ridge, New JerseyAges 18 years+ - NCT07044310RecruitingPhase 2
Probiotics for preventing bone loss during breast cancer hormone therapy
This trial tests if a probiotic supplement can help prevent bone loss in women with HR-positive breast cancer who are starting an aromatase inhibitor. You would take the probiotic daily and provide blood and stool samples to see how it affects your bone health.
Jacksonville, FloridaAges 18 years+ - NCT07054190RecruitingPhase 2
Testing Inavolisib in early-stage breast cancer with PIK3CA mutation
This trial is testing a drug called Inavolisib (a type of targeted therapy) given before surgery for people with early-stage, hormone receptor-positive, HER2-negative breast cancer that has a specific genetic change (PIK3CA mutation). The goal is to see if adding Inavolisib to standard endocrine therapy can shrink the tumor more effectively.
Los Angeles, CaliforniaAges 18 years+ - NCT07071038RecruitingPhase 2
Switching medication to relieve side effects from aromatase inhibitors
This trial tests whether switching to a different aromatase inhibitor or using standard treatments works better for managing side effects in breast cancer survivors. It aims to help you stay on hormone therapy longer with fewer discomforts.
Lebanon, New HampshireAges 18 years+ - NCT07095114Recruiting
Disappearing markers for daily breast radiation
This study tests whether small disappearing ink marks can be used to guide daily radiation treatments for breast cancer. It may help make radiation more precise and comfortable.
Detroit, MichiganAges 18 years+ - NCT07109817RecruitingPhase 2
Desloratadine to prevent nerve damage from taxane chemo in breast cancer
This trial tests if the allergy medicine desloratadine can prevent nerve damage (numbness, tingling, pain) caused by taxane chemotherapy in people with early-stage breast cancer. Taking desloratadine daily during chemo may help protect your nerves.
The Bronx, New YorkAges 18 years+
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Common questions
- Are there clinical trials for breast cancer stage iii?
- Yes. Clin2 currently lists 527 recruiting breast cancer stage iii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage iii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage iii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Anatomic Stage III Breast Cancer AJCC v8
- Prognostic Stage III Breast Cancer AJCC v8
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Non-small Cell Lung Cancer Stage III
- Anatomic Stage I Breast Cancer AJCC v8
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.