Clinical trials
Breast Cancer Stage IV clinical trials
Below are recruiting breast cancer stage iv clinical trials, each written for real people, not researchers. We’re tracking 472 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06793813RecruitingPhase 2
Study of cadonilimab for advanced lung cancer
This trial tests a new drug called cadonilimab for people with advanced non-squamous non-small cell lung cancer that has gotten worse after treatment with immunotherapy and chemotherapy. The goal is to see if it helps control the cancer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04741997RecruitingEarly Phase 1
Adjuvant melanoma treatment guided by response to targeted drugs
This early-phase study looks at whether people with melanoma can get the “right” follow-up (extra) treatment based on how well their cancer responds after starting targeted drugs before surgery. The goal is to improve outcomes while better matching treatment to each person’s tumor response.
Tampa, FloridaAges 18 years+ - NCT05281406RecruitingPhase 2
Extra chemotherapy if tumor DNA stays positive after osimertinib
This Phase 2 trial tests whether adding chemotherapy can help people with EGFR-mutated lung cancer when their cancer-related blood test (liquid biopsy for EGFR DNA) is still positive after 3–4 weeks of starting osimertinib. It may help slow the cancer for longer by treating any remaining disease activity.
BerlinAges 18 years+ - NCT05428007RecruitingPhase 2
Sarilumab with three immunotherapy drugs for advanced melanoma
This Phase 2 trial tests whether adding sarilumab (an immune-blocking medicine) to three immunotherapy medicines can shrink unresectable, advanced melanoma that cannot be removed with surgery. It aims to improve how well the immune system controls the cancer, especially in Stage III or Stage IV disease.
Los Angeles, CaliforniaAges 18–100 - NCT06204991RecruitingPhase 1
T-cell therapy for advanced melanoma
This trial tests a new treatment called ADP-TILIL7 for people with advanced melanoma. It uses your own immune cells (T-cells) that are taken from a tumor, multiplied in a lab, and then given back to you to fight the cancer. The goal is to see if this treatment is safe and works better than standard options.
HerlevAges 18–75 - NCT05107674RecruitingPhase 1
Early drug study for advanced cancers that have limited options
This Phase 1 study tests NX-1607 in adults with advanced cancers that are hard to treat with standard care. It focuses on safety and early signs of how well the drug may work in specific cancer types.
Duarte, CaliforniaAges 18 years+ - NCT07215988Recruiting
Studying insurance for skin cancer treatment
This study looks at how insurance covers immunotherapy given before surgery for certain skin cancers. It includes people with Merkel cell, mucosal melanoma, basal cell, or other rare skin cancers who are planning to have surgery.
Columbus, OhioAges 18 years+ - NCT04845828Recruiting
Sentinel node biopsy versus full node removal in early uterine cancer
This study compares two ways to check lymph nodes during surgery for early-stage endometrial (uterine) cancer: sentinel node biopsy versus removing more lymph nodes. It may help find whether the less extensive approach can stage the cancer accurately with fewer side effects.
SeoulAges 20–80 - NCT07116161Recruiting
Exercise and counseling for fatigue in female breast cancer patients
This trial tests if combining exercise with cognitive behavioral therapy (counseling) can help reduce fatigue in women with breast cancer. You may be able to join if you have completed your initial treatments and still feel tired.
SingaporeAges 21 years+ - NCT07432633RecruitingPhase 1/Phase 2
Imaging scan to detect cancer-linked protein in several tumor types
This trial tests a new PET scan tracer that targets a protein found on certain cancer cells. It may help doctors better see and understand tumors in people with colorectal, gastric, pancreatic, lobular breast, or ovarian cancer.
Dallas, TexasAges 18–80 - NCT05877599RecruitingPhase 1
Study of a new treatment for advanced cancers with a specific gene change
This trial tests a new type of therapy (NT-175) for people with certain advanced cancers that have a specific genetic change. It might help if your tumor has the TP53 R175H mutation and you have the HLA-A*02:01 immune marker.
Gilbert, ArizonaAges 18 years+ - NCT06817694Recruiting
CBT for fear of cancer returning in BRCA1/2 women
This trial tests if cognitive behavioral therapy can reduce fear of cancer recurrence in women with BRCA1/2 mutations who have finished treatment for breast or ovarian cancer. It aims to help you cope with worries about cancer coming back.
Québec, QuebecAges 18 years+ - NCT04595929Recruiting
Tested aerosol chemotherapy inside the abdomen for stomach cancer
This trial looks at a way to give chemotherapy into the abdomen (through a small tube during laparoscopy) for certain stomach cancers. It aims to see whether this approach improves cancer control and surgical outcomes for people whose tumors can potentially be removed.
Saint PetersburgAges 18–65 - NCT05289258Recruiting
Barlow-style program for thinking and memory problems after breast cancer
This trial tests a structured “Barlow Protocol” program to help improve mild to moderate thinking and memory problems in people who finished breast cancer chemotherapy. It may help if your cognitive symptoms started after treatment and you’re not already in similar therapy.
CórdobaAges 18–70 - NCT07120282RecruitingPhase 2
Tislelizumab after surgery for early-stage lung cancer
This trial tests whether a drug called tislelizumab, given after surgery, can help prevent lung cancer from coming back. It is for people with stage I non-small cell lung cancer who have certain high-risk features and a protein called PD-L1 on their tumor cells.
BeijingAges 18 years+ - NCT06807632RecruitingPhase 1
Study of two drugs for extensive-stage small cell lung cancer
This trial tests a new combination of two drugs (valemetostat and atezolizumab) for people with extensive-stage small cell lung cancer who have already responded to initial chemo-immunotherapy. The goal is to see if adding valemetostat can keep the cancer from growing longer.
Basking Ridge, New JerseyAges 18 years+ - NCT06188520RecruitingPhase 1/Phase 2
Study of a new drug for advanced solid tumors in women
This trial tests a new drug, AZD8421, alone or with other treatments, for women with advanced solid tumors that have not responded to prior therapies. It aims to find a safe dose and see if it can help shrink or control the cancer.
St Louis, MissouriAges 18 years+ - NCT06596018RecruitingPhase 1/Phase 2
Radiation therapy for breast cancer not responding to chemo
This trial tests whether adding a special type of radiation (SBRT) can help people whose breast cancer did not shrink after two rounds of standard chemotherapy. It's for people with stage II or III breast cancer that is still growing or stable.
Hangzhou, ZhejiangAges 18–75 - NCT03375983RecruitingPhase 1/Phase 2
Immune treatment with malaria cells for advanced solid cancers
This early-phase study tests a “malaria-based” immune treatment to help the immune system fight advanced cancers. It’s designed for people whose cancer can be measured on scans and whose organs and blood counts are strong enough for immunotherapy.
Guangzhou, GuangdongAges 18–70 - NCT05885009Recruiting
Liquid biopsy test to guide treatment in metastatic prostate cancer
This study looks at using a simple blood test (liquid biopsy) to read tumor DNA and understand how it could affect treatment decisions. It is for adults with metastatic prostate cancer who are about to start, are receiving, or recently finished treatment.
BarcelonaAges 18 years+ - NCT03758976Recruiting
Study of scans in advanced breast cancer recurrence
This study looks at people with advanced breast cancer to better understand recurrence by using information from recent scans. It may help researchers improve how advanced disease is assessed and followed over time.
LundAges 18 years+ - NCT06736613RecruitingPhase 2
Blood test for tumor DNA in high-risk B-cell lymphoma
This trial uses a blood test to look for tumor DNA in people with high-risk B-cell lymphoma, to help predict if the lymphoma might spread to the brain or spinal cord. It may help doctors decide on extra treatments to prevent that spread.
Basking Ridge, New JerseyAges 18 years+ - NCT06518135Recruiting
Sentinel node biopsy after chemo for initial node-positive breast cancer
This trial checks whether a less invasive sentinel lymph node biopsy (removing just a few nodes) can safely replace full lymph node removal for people whose breast cancer and underarm lymph nodes responded well to chemotherapy. It is for patients who initially had 1 to 3 involved nodes and now appear cancer-free in the armpit.
Henan, HenanAges 18–70 - NCT06745076RecruitingPhase 2
Using a blood test to safely lower chemo for advanced Hodgkin lymphoma
This trial studies whether a blood test (ctDNA) can help doctors safely reduce chemotherapy for people with advanced Hodgkin lymphoma. If you have stage 3 or 4 Hodgkin lymphoma that hasn't been treated yet and are healthy enough for strong chemo, this study may be an option for you.
Irvine, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for breast cancer stage iv?
- Yes. Clin2 currently lists 472 recruiting breast cancer stage iv studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage iv trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage iv trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Early-stage Breast Cancer
- Breast Cancer Stage III
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.